| Metocurine | Metocurine is a muscle relaxant. |
| Botulinum toxin type B | A purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea. |
| Rasburicase | A recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma. |
| Botulinum toxin type A | A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications. |
| Cholecalciferol | A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease. |
| Baclofen | A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. |
| Succinylcholine | A depolarizing skeletal muscle relaxant used as an adjunct to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. |
| Pamidronic acid | A bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. |
| Chlorzoxazone | A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. |
| Carisoprodol | A centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions. |
| Zoledronic acid | A bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. |
| Methocarbamol | A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. |
| Allopurinol | A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. |
| Nabumetone | An NSAID used to treat osteoarthritis and rheumatoid arthritis. |
| Tenoxicam | An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. |
| Tolmetin | An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. |
| Rofecoxib | A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. |
| Piroxicam | An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. |
| Cisatracurium | A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation. |
| Fenoprofen | An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. |
| Valdecoxib | A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. |
| Sulindac | An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. |
| Alendronic acid | A bisphosphonate drug that prevents osteoclastic bone resorption and is used for the prevention and treatment of osteoporosis. |
| Tizanidine | An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. |
| Ibandronate | A bisphosphonate used to treat osteoporosis in postmenopausal women. |
| Clodronic acid | A bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis. |
| Rocuronium | A vecuronium analog used to facilitate tracheal intubation and to relax skeletal muscles during surgery. |
| Etodolac | An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. |
| Mefenamic acid | An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. |
| Phenylbutazone | An NSAID used to treat backache and ankylosing spondylitis. |
| Meloxicam | An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. |
| Penicillamine | A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. |
| Suprofen | An NSAID used to prevent pupil constriction in ocular surgery. |
| Risedronic acid | A bisphosphonate used to treat osteoporosis and Paget's disease. |
| Cyclobenzaprine | A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. |
| Meclofenamic acid | An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. |
| Hexafluronium | Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations. |
| Oxaprozin | An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. |
| Auranofin | An antirheumatic used to treat active, progressive, or destructive forms of inflammatory arthritis. |
| Ketoprofen | An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. |
| Etidronic acid | A bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis. |
| Dimethyl sulfoxide | A reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer. |
| Tiludronic acid | A bisphosphonate used for the treatment of Paget's disease of bone. |
| Doxacurium | A nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. |
| Sulfinpyrazone | A platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout . |
| Orphenadrine | A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. |
| Chlormezanone | Used in the management of anxiety and in the treatment of muscle spasm. |
| Tubocurarine | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... |
| Dantrolene | A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis. |
| Mivacurium | A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation. |
| Lumiracoxib | For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. |
| Glucosamine | Glucosamine is usually used in the treatment of osteoarthritis, although its efficacy is still in question. |
| Pancuronium | A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. |
| Pipecuronium | A nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures. |
| Vecuronium | A nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures. |
| Calcium | A mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency. |
| Colchicine | An alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). |
| Alfacalcidol | A vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure. |
| Tiaprofenic acid | A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. |
| Etoricoxib | For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. |
| Flufenamic acid | An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th... |
| Oxyphenbutazone | A nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. |
| Niflumic acid | Used in the treatment of rheumatoid arthritis. |
| Nimesulide | For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. |
| Benoxaprofen | The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... |
| Zomepirac | Zomepirac was indicated for the management of mild to severe pain. |
| Febuxostat | A xanthine oxidase inhibitor used for the management of chronic hyperuricemia in adults with gout who have an inadequate response or intolerance to allopurinol. |
| Ataluren | A medication used for the treatment of Duchenne muscular dystrophy. |
| Tolperisone | Investigated for use/treatment in neurologic disorders, spinal cord injuries, muscle spasm, back pain, and multiple sclerosis. |
| Denosumab | A RANK ligand (RANKL) inhibitor used for the management of osteoporosis in patients at high risk for bone fractures. |
| Naproxcinod | Investigated for use/treatment in pain (acute or chronic), inflammatory disorders (unspecified), osteoarthritis, and arthritis and arthritic pain. |
| Lornoxicam | For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases. |
| Aceclofenac | Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. |
| Chymopapain | Chymopapain is indicated for the development of chemonucleolysis which is used for the digestion of the nucleus pulposus in patients with disc herniation confirmed by myelography. A disc herniation occurs... |
| Azapropazone | Not Available |
| Felbinac | Not Available |
| Parecoxib | A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. |
| Kebuzone | Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. |
| Indoprofen | A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. |
| Ibuproxam | Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). |
| Fenbufen | Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... |
| Etofenamate | Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID). |
| Eperisone | Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression... |
| Zucapsaicin | A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. |
| Aurothioglucose | A gold compound used in the treatment of rheumatoid arthritis. |
| Pegloticase | A recombinant uricase used for the treatment of chronic gout in adult patients refractory to conventional therapy. |
| Dexibuprofen | For more information, refer to ibuprofen. |
| Dexketoprofen | For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache . |
| Droxicam | Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . |
| Tolfenamic acid | In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. |
| Strontium ranelate | A medication used for the management of severe osteoporosis in high-risk postmenopausal women and adult men. |
| Sodium aurothiomalate | A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis. |
| Morniflumate | Morniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for... |
| Chondroitin sulfate | Chondroitin sulfate, used with glucosamine, is indicated to alleviate pain and inflammation from primary osteoarthritis. This supplement is reported to improve joint function and slow disease progression. Osteoarthritis is characterized... |
| Lesinurad | A uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy. |
| Thiocolchicoside | Thiocolchicoside is a skeletal muscle-relaxant drug used in the treatment of orthopedic, traumatic and rheumatologic disorders . It is indicated as an adjuvant drug in the treatment of painful muscle... |
| Eptotermin alfa | A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin alfa is an ingredient in... |
| Dibotermin alfa | indicated for the treatment of acute tibia fractures in adults, as an adjunct to standard care using open fracture reduction and intramedullary unreamed nail fixation [FDA Label].
indicated for single-level... |
| Diacerein | For the treatment of osteoarthritis affecting the hip or knee . |
| Bucillamine | Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. |
| Benzbromarone | Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia. |
| Alclofenac | Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. |
| Fentiazac | Not Annotated |
| Suxibuzone | Not Annotated |
| Bumadizone | Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... |
| Atracurium | Not Annotated |
| Idrocilamide | Not Annotated |
| Febarbamate | Not Annotated |
| Oxametacin | Not Annotated |
| Alminoprofen | Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. |
| Tetrazepam | Not Annotated |
| Bufexamac | An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. |
| Phenprobamate | Not Annotated |
| Styramate | Not Annotated |
| Feprazone | Not Annotated |
| Difenpiramide | Not Annotated |
| Nifenazone | Not Annotated |
| Fenyramidol | Not Annotated |
| Lonazolac | Not Annotated |
| Tenidap | Not Annotated |
| Proglumetacin | Not Annotated |
| Isobromindione | Not Annotated |
| Cinchophen | Not Annotated |
| Mephenesin | A cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis. |
| Gallamine | Not Annotated |
| Oxycinchophen | Not Annotated |
| Ipriflavone | Not Annotated |
| Mofebutazone | Not Annotated |
| Pridinol | Not Annotated |
| Alcuronium | A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. |
| Proquazone | Not Annotated |
| Drisapersen | Not Annotated |
| Hydroquinine | Not Annotated |
| Pirprofen | Not Annotated |
| Sodium aurotiosulfate | Not Annotated |
| Fazadinium bromide | Not Annotated |
| Aurotioprol | Not Annotated |
| Acemetacin | Acemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation... |
| Tisopurine | Not Annotated |
| Collagenase clostridium histolyticum | A collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease. |
| Indomethacin | A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. |
| Ketorolac | An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. |
| Quinine | An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. |
| Celecoxib | An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. |
| Diclofenac | An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. |
| Flurbiprofen | An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. |
| Esomeprazole | A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. |
| Naproxen | An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. |
| Tolazoline | A vasodilator used to treat pulmonary artery anomalies. |
| Misoprostol | A prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers. |
| Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. |
| Probenecid | A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. |
| Rabeprazole | A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. |
| Capsaicin | A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. |
| Hyaluronic acid | A glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications. |
| Benzydamine | A locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy. |
| Trypsin | Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide... |
| Aluminum chlorohydrate | A compound used as an antiperspirant. |
| Bromelains | Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase,... |
| Flunoxaprofen | Not Annotated |
| Oxaceprol | Not Annotated |
| Bendazac | Prior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the... |
| Dipyrocetyl | Not Annotated |
| Eteplirsen | An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation. |
| Aceneuramic acid | Aceneuramic acid has been used in trials studying the treatment of Distal Myopathy, Nonaka Type, Hereditary Inclusion Body Myopathy, and Distal Myopathy With Rimmed Vacuoles. |
| Romosozumab | A monoclonal antibody used to treat osteoporosis in postmenopausal women at high risk of fracture, patients who are intolerant of other treatments, or patients who have failed other treatments. |
| Polmacoxib | Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee. |
| Nusinersen | A medication used to treat spinal muscular atrophy. |
| Burosumab | A fibroblast growth factor 23 blocking antibody used to treat X-linked hypophosphatemia. |
| Viltolarsen | An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. |
| Casimersen | An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. |