Lorcainide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Lorcainide
- DrugBank Accession Number
- DB13653
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 370.916
Monoisotopic: 370.181191203 - Chemical Formula
- C22H27ClN2O
- Synonyms
- Lorcainide
- External IDs
- RO 13-1042
- RO-13-1042
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol Acebutolol may increase the arrhythmogenic activities of Lorcainide. Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Lorcainide. Acrivastine The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Lorcainide. Adenosine Adenosine may increase the arrhythmogenic activities of Lorcainide. Ajmaline Ajmaline may increase the arrhythmogenic activities of Lorcainide. - Food Interactions
- Not Available
Categories
- ATC Codes
- C01BC07 — Lorcainide
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Phenylacetamides
- Direct Parent
- Phenylacetamides
- Alternative Parents
- Anilides / Chlorobenzenes / Piperidines / Aryl chlorides / Tertiary carboxylic acid amides / Trialkylamines / Amino acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organochlorides show 3 more
- Substituents
- Amine / Amino acid or derivatives / Anilide / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Carbonyl group / Carboxamide group / Carboxylic acid derivative show 17 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- KGJ2T0N7IQ
- CAS number
- 59729-31-6
- InChI Key
- XHOJAWVAWFHGHL-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3
- IUPAC Name
- N-(4-chlorophenyl)-2-phenyl-N-[1-(propan-2-yl)piperidin-4-yl]acetamide
- SMILES
- CC(C)N1CCC(CC1)N(C(=O)CC1=CC=CC=C1)C1=CC=C(Cl)C=C1
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0041918
- ChemSpider
- 39116
- BindingDB
- 50237589
- ChEBI
- 135568
- ChEMBL
- CHEMBL87543
- ZINC
- ZINC000000537935
- Wikipedia
- Lorcainide
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00749 mg/mL ALOGPS logP 4.59 ALOGPS logP 4.31 Chemaxon logS -4.7 ALOGPS pKa (Strongest Basic) 8.83 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 23.55 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 108.18 m3·mol-1 Chemaxon Polarizability 40.88 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-9440000000-15d6038071c0a1a4e316 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-0029000000-3cdd89cf22fc47ba111d Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0019000000-053938e393273e64601a Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0umi-1194000000-8f2d228eed4f87293321 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0uxu-9455000000-44333df2e78ad8e1c71b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0w2c-5896000000-70f932dfe3b70f5124d1 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-4591000000-8d649f17b60806b89886 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 195.7907331 predictedDarkChem Lite v0.1.0 [M-H]- 184.26016 predictedDeepCCS 1.0 (2019) [M+H]+ 195.7803331 predictedDarkChem Lite v0.1.0 [M+H]+ 186.61815 predictedDeepCCS 1.0 (2019) [M+Na]+ 196.2189331 predictedDarkChem Lite v0.1.0 [M+Na]+ 194.31871 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:46 / Updated at February 21, 2021 18:54