- Accession Number
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
- ATC Classification
Drug Drug Description Raltitrexed A folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. Tioguanine A purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Capecitabine A nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Tegafur An antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. Floxuridine An antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Trifluridine A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. Choline A nutrient found in a wide variety of vitamins including pre-natal formulations. Vidarabine An antiviral agent used to treat various viral infections. Cycloserine A broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). Allopurinol A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Propylthiouracil A thiourea antithyroid agent used to treat hyperthyroidism. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Ribavirin A guanosine nucleoside used to treat some forms of Hepatitis C. Didanosine A reverse transcriptase inhibitor used to treat HIV. Zalcitabine A dideoxynucleoside used to treat HIV. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Flucytosine An antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus. Proguanil A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Trimetrexate A folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. 8-azaguanine 8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... 2-deoxyglucose As of July 2013, there is no approved therapeutic indication for 2-deoxyglucose. 2-deoxyglucose may have several potential indications as an adjunct to chemotherapy and radiotherapy in the treatment of solid... Broxuridine Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer. Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. Lometrexol Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific. Buthionine Sulfoximine Buthionine Sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin). Nolatrexed Nolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer). Doxifluridine Doxifluridine has been investigated for the treatment of Stomach Cancer. Tiazofurine Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase . Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Pemetrexed A folate analog used to treat mesothelioma and non-small cell lung cancer. Nelarabine A purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments. Pralatrexate An antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma. Carmofur Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. Meglutol An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as... Insulin glargine A modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus. Platensimycin Not Available Evolocumab A PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. Bococizumab Bococizumab has been used in trials studying the treatment and prevention of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, and Heterozygous Familial Hypercholesterolemia. Bendazac Prior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the...
- Drugs & Drug Targets