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Acetylsalicylic Acid Action Pathway (New)
smpdb.ca/view/SMP0124628Drug actionAspirin (acetylsalicylic acid) is an NSAID used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. … It leads to the formation of prostaglandin E2 which is responsible for contributing to the inflammatory response by activating immune cells and for increasing pain sensation by acting on pain fibers.
Drugs: Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Mesoheme · Prostaglandin G2 +1 moreNalidixic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174549MetabolicMetabolites of Nalidixic acid are predicted with biotransformer.
Iocetamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174586MetabolicMetabolites of Iocetamic acid are predicted with biotransformer.
Lysosomal Acid Lipase Deficiency (Wolman Disease)
smpdb.ca/view/SMP0000319DiseaseLysosomal Acid Lipase Deficiency, also known as Wolman disease, is predictably enough the result of a specific defect in lysosomal acid lipase. … Symptoms include anemia, diarrhea, failure to thrive, enlarged liver, malabsorption, steatorrhea and abdominal pain.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseApoptotic DNA Fragmentation and Tissue Homeostasis
smpdb.ca/view/SMP0063772SignalingEndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis. … ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent.
Drugs: ZincMetabolism and Physiological Effects of Creatinine
smpdb.ca/view/SMP0123283MetabolicFirst, it forms guanidinoacetic acid in a reaction catalysed by glycine amidinotransferase, then undergoes a reaction catalysed by guanidinoacetate N-methyltransferase to form creatine. … Arginine from the diet is absorbed into systemic circulation and enters hepatocytes through an amino acid transporter, where it undergoes a series of metabolic reactions.
Enzymes: Y+L amino acid transporter 2Metabolism and Physiological Effects of Xanthine
smpdb.ca/view/SMP0124865MetabolicAdenosine then reacts with water to form inosine and ammonia using the enzyme adenosine deaminase. Inosine goes on to form hypoxanthine through the enzyme purine nucleoside phosphorylase. … Xanthine is formed from purine catabolism. Purines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine.
Metabolism and Physiological Effects of Kynurenine
smpdb.ca/view/SMP0125524DiseaseIn the blood it travels to the liver and is transported into a hepatocyte by an amino acid transporter. … Tryptophan is consumed through foods such as milk, eggs, chicken, turkey, and oats. Tryptophan is then transported from the small intestine into the blood by an amino acid transport.
Enzymes: Neutral and basic amino acid transport protein rBAT, Neutral amino acid transporter AMetabolism and Physiological Effects of Isovalerylglycine
smpdb.ca/view/SMP0126748MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … and its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results.
Metabolism and Physiological Effects of Tiglylglycine
smpdb.ca/view/SMP0126840MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … In the mitochondria, isoleucine is converted to 2-oxo-3-methylvaleric acid vis a transaminase. This is then converted into 2-methylbutyryl-CoA by the BCKADH complex.
Enzymes: Branched-chain-amino-acid aminotransferase, mitochondrial, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial