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Risedronate Action Pathway
smpdb.ca/view/SMP0000112Drug actionRisedronate (also named Actonel, Atelvia or Benet.) is a type of medication that used to treat numbers of bone diseases because of its affinity for hydroxyapatite. Risedronate targets farnesyl pyrophosphate (FPP) synthase by inhibiting t...
Drugs: Cholecalciferol · ATP · Risedronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseViral Sepsis
smpdb.ca/view/SMP0125490DiseaseThe reduction in essential amino acids is intended to “starve” the invading viruses (and other pathogens) of the amino acids they need to reproduce [4]. … and the production of fatty acids and acylcarnitines (needed for lipid synthesis).
Enzymes: Low affinity cationic amino acid transporter 2Bacterial Sepsis
smpdb.ca/view/SMP0125493DiseaseThe reduction in essential amino acids is intended to “starve” the invading bacteria (and other pathogens) of the amino acids they need to reproduce [4]. … and the production of fatty acids and acylcarnitines (needed for lipid synthesis).
Enzymes: Low affinity cationic amino acid transporter 2Tryptophan Metabolism
smpdb.ca/view/SMP0000063MetabolicK, GTK) catabolizes its conversion into kynurenic acid. … The action of kynurenine 3-hydroxylase on kynurenic acid leads to 3-hydroxykynurenine.
Drugs: Pyridoxal phosphate · Ademetionine · Adenosine phosphate · Glutamic acid · Tryptophan · NADH +18 moreEnzymes: Aromatic-L-amino-acid decarboxylaseClomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionClomipramine is a strong serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine (which is formed by N-demethylation of clomipramine via CYP2C19, 3A4, and 1A2) acts preferably
Enzymes: Aromatic-L-amino-acid decarboxylaseDimethylglycine Dehydrogenase Deficiency
smpdb.ca/view/SMP0125578DiseaseDimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Proton-coupled amino acid transporter 2Non-Ketotic Hyperglycinemia
smpdb.ca/view/SMP0125580Diseaseglycine (glycine cleavage system), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreNon-Ketotic Hyperglycinemia
smpdb.ca/view/SMP0000223Diseaseglycine (glycine cleavage system), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreSarcosinemia
smpdb.ca/view/SMP0125579Diseaseknown as hypersarcosinemia, sarcosine dehydrogenase complex deficiency, SARDH deficiency, SARDHD or SARD deficiency, is an autosomal recessive metabolic disorder leading to increased levels of the amino acid … Sarcosine can be formed from a series of reactions starting with trimethylglycine.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreGlycine and Serine Metabolism
smpdb.ca/view/SMP0000004MetabolicCystathionine beta-lyase then converts this double amino acid to cysteine, ammonia, and alpha-ketoglutarate. Glycine is biosynthesized in the body from the amino acid serine. … Serine is central to the synthesis and breakdown of the other two amino acids.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more