Search
Metoclopramide - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126993Drug actionMetoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric … Consequently, it increases the resting tone of the lower esophageal sphincter while simultaneously relaxing the duodenal bulb and pyloric sphincter, thereby increasing the peristalsis of the duodenum and
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorCongenital Disorder of Glycosylation CDG-IId
smpdb.ca/view/SMP0000579DiseaseThis protein is responsible for the conversion of D-glucose and uridine diphosphategalactose to alpha-lactose and uridine 5’-diphosphate. … of oligosaccharides and their transfer.
Hyperprolinemia Type II
smpdb.ca/view/SMP0000360DiseaseThis enzyme is responsible for catalyzing the dehydrogenation of 1-pyrroline-5-carboxylic acid or L-glutamic gamma-semialdehyde into L-glutamic acid. … Symptoms include hydroxyprolinuria and hyperglycinuria, and can include seizures and some amount of mental retardation.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: D-amino-acid oxidaseRefsum Disease
smpdb.ca/view/SMP0000451DiseaseA defect in phytanoyl-CoA hydroxylase results in accumulation of phytanic acid in the plasma, as well as low levels of pristanic acid due to the inability for phytanic acid to undergo alpha and beta oxidation … Adult Refsum Disease (Classic Refsum Disease; Phytanic Acid Oxidase Deficiency; Heredopathia Atactica Polyneurtiformis; Hereditary Motor and Sensory Neuropathy IV; HSMN4; Adult Refsum Disease I; Adult
Enzymes: ATP-binding cassette sub-family D member 1, ATP-binding cassette sub-family D member 2Refsum Disease
smpdb.ca/view/SMP0125805DiseaseA defect in phytanoyl-CoA hydroxylase results in accumulation of phytanic acid in the plasma, as well as low levels of pristanic acid due to the inability for phytanic acid to undergo alpha and beta oxidation … Adult Refsum Disease (Classic Refsum Disease; Phytanic Acid Oxidase Deficiency; Heredopathia Atactica Polyneurtiformis; Hereditary Motor and Sensory Neuropathy IV; HSMN4; Adult Refsum Disease I; Adult
Enzymes: ATP-binding cassette sub-family D member 1, ATP-binding cassette sub-family D member 2Coagulation
smpdb.ca/view/SMP0130473PhysiologicalIn the liver the coagulation factors VII, IX, and X are produced there as they are vitamin K-dependent proteins. … The intrinsic pathway is activated by trauma inside vasculature and is activated by platelets, exposed endothelium and collagen.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1Fluspirilene Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126514Drug actionFluspirilene is an antipsychotic agent used in the treatment of schizophrenia. Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorKetone Body Metabolism
smpdb.ca/view/SMP0000071MetabolicAcetoacetic acid can also be catalyzed by mitochondrial D-beta-hydroxybutyrate dehydrogenase to form (R)-3-Hydroxybutyric acid with NADH. Ketogenesis occurs mostly during fasting and starvation. … Acetoacetic acid (acetoacetate) will be catalyzed to form acetoacetyl-CoA irreversibly by 3-oxoacid CoA-transferase 1 that also coupled with interconversion of succinyl-CoA and succinic acid.
Enzymes: D-beta-hydroxybutyrate dehydrogenase, mitochondrialDicoumarol Action Pathway
smpdb.ca/view/SMP0000656Drug actionVitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1Warfarin Action Pathway
smpdb.ca/view/SMP0000268Drug actionIn the endoplasmic reticulum within the liver, vitamin K1 2,3-epoxide would regularly use vitamin K epoxide reductase complex subunit 1 to become reduced vitamin K (phylloquinone), and then back to vitamin … The enzyme vitamin K-dependent gamma carboxylase catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1