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Phenylalanine and Tyrosine Metabolism
smpdb.ca/view/SMP0000008MetabolicIn man, phenylalanine is an essential amino acid which must be supplied in the dietary proteins. Once in the body, phenylalanine may follow any of three paths. It may be (1) incorporated into cellular proteins, (2) converted to phenylpyr...
Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 moreInositol Metabolism
smpdb.ca/view/SMP0000011MetabolicThe carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from...
Drugs: ATP · Calcium · Magnesium cation · Iron · 1D-myo-inositol 1,3,4-trisphosphate · Pyrophosphoric acid +1 moreVitamin B6 Metabolism
smpdb.ca/view/SMP0000017MetabolicAs is commonly known there are many vitamins, the vitamin B complex group being one of the most well known. An important vitamin B complex group vitamin is vitamin B6, which is water-soluble. Moreover, this vitamin comes in various forms...
Drugs: Pyridoxal phosphate · Pyridoxal · Pyridoxine · Magnesium cation · Zinc · Pyridoxamine-5'-Phosphate +3 morePentose Phosphate Pathway
smpdb.ca/view/SMP0000031MetabolicThe pentose phosphate pathway—also referred to in the literature as the phosphogluconate pathway, the hexose monophosphate shunt, or the pentose phosphate shunt—is involved in the generation of NADPH as well as pentose sugars. Of the tot...
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreFolate Metabolism
smpdb.ca/view/SMP0000053MetabolicFolate, or folic acid, is a very important B-vitamin involved in cell creation and preservation, as well as the protection of DNA from mutations that can cause cancer. It is commonly found in leafy green vegetables, but is also present i...
Simvastatin Action Pathway
smpdb.ca/view/SMP0000082Drug actionSimvastatin, the methylated form of lovastatin, is an inactive lactone that is metabolized in vivo to β,δ-dihydroxy acid, its most potent metabolite. Cytochrome P450 (CYP) enzymes, CYP3A4, CYP3A5, and CYP2C8, have been implicated in this...
Drugs: Cholecalciferol · ATP · Simvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreLovastatin Action Pathway
smpdb.ca/view/SMP0000099Drug actionLovastatin (also known as Mevacor or Mevinolin) is a statin drug (hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors) that can be used for lowering cholesterol, treating hypercholesterolemia and preventing myocardial infarct...
Drugs: Cholecalciferol · ATP · Lovastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 morePamidronate Action Pathway
smpdb.ca/view/SMP0000117Drug actionIbandronate (also named ibandronate sodium) is a type of medication that used to treat numbers of bone diseases because of its affinity for hydroxyapatite. Ibandronate targets farnesyl pyrophosphate (FPP) synthase by inhibiting the funct...
Drugs: Cholecalciferol · ATP · Pamidronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreFluvastatin Action Pathway
smpdb.ca/view/SMP0000119Drug actionFluvastatin inhibits cholesterol synthesis via the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is the enzyme responsible for the conversion of HMG-CoA to mevalonic acid, t...
Drugs: Cholecalciferol · ATP · Fluvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreDihydropyrimidinase Deficiency
smpdb.ca/view/SMP0000178DiseaseDihydropyrimidinase Deficiency (DHPA, Dihydropyrimidinuria Deficiency, DPH Deficiency) is an autosomal recessive disease caused by a mutation in the DPYS gene which codes for dihydropyrimidinase. A deficiency in this enzyme results in ac...