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Phenylalanine and Tyrosine Metabolism
smpdb.ca/view/SMP0000008MetabolicTyrosine can be converted into L-DOPA, which is further converted into dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline).
Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 morePenbutolol Action Pathway
smpdb.ca/view/SMP0000305Drug actionPenbutolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure
Desipramine Metabolism Pathway
smpdb.ca/view/SMP0000626Drug metabolismHigher concentrations of norepinephrine and serotonin have also been shown to have long-term neuromodulatory effects. … Desipramine is a tricyclic antidepressant that exerts its therapeutic effects by inhibiting norepinephrine and serotonin reuptake in the brain.
Venlafaxine Metabolism Pathway
smpdb.ca/view/SMP0000636Drug metabolismN-desmethylvenlafaxine is a weaker serotonin and norepinephrine reuptake inhibitor. … Venlafaxine (also named as Effexor or Elafax) is an antidepressant medication, which belongs to the class of serotonin-norepinephrine reuptake inhibitor (SNRI).
Tramadol Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125025Drug actionTramadol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
Drugs: ATP · Tramadol · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreMethylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125204Drug actionThis abnormality makes it harder for dopamine and norepinephrine to bind to the receptors. … Methylphenidate blocks the reuptake transporters of both dopamine and norepinephrine which prolongs their duration in the synapse so that they can bind more readily to the receptors.
Bupropion Metabolism
smpdb.ca/view/SMP0125320MetabolicHydroxybupropion has been shown to have the same affinity for norepinephrine reuptake transporters, but only 50% of the anti-depressant effects of bupropion.
Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126423Drug actionIt is suggested that venlafaxine has a 30-fold selectivity for serotonin compared to norepinephrine: venlafaxine initially inhibits serotonin reuptake at low doses, and with higher doses, it inhibits norepinephrine … not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) potently and selectively inhibits the reuptake of both serotonin and norepinephrine
Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126744Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mostly in the brain.
Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126746Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … Phenelzine inhibits both isoforms causing an elevation in brain levels of catecholamines (like norepinephrine) and serotonin. This drug is administered as an oral tablet.