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Antrafenine Action Pathway
smpdb.ca/view/SMP0000693Drug actionAntrafenine (also named Stakane) acts as an anti-inflammatory and analgesic drug. It is not widely used as it has largely been replaced by newer drugs. Antrafenine can block prostaglandin synthesis by the action of inhibition of prostagl...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Antrafenine +5 moreCarprofen Action Pathway
smpdb.ca/view/SMP0000694Drug actionCarprofen (also named Rimadyl or Imadyl) is a nonsteroidal anti-inflammatory drug that can treat various joint pain or post-operative pain. Carprofen can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synt...
Lumiracoxib Action Pathway
smpdb.ca/view/SMP0000699Drug actionLumiracoxib (also named Prexige) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used as the mediators of certain kinds of intraocular inflammation. Lumiracoxib can block prostaglandin synthesis by the action of inhibition of...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Lumiracoxib · Calcium · Magnesium cation +5 more3-Phosphoglycerate Dehydrogenase Deficiency
smpdb.ca/view/SMP0000721Disease3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreTemocapril Action Pathway
smpdb.ca/view/SMP0000733Drug actionTemocapril (trade name: Acecol) belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of conge...
Roxatidine Acetate Action Pathway
smpdb.ca/view/SMP0000734Drug actionRoxatidine acetate is an anti-ulcer agent, that works through antagonizing the histamine H2 receptor. It is used to reduce abdominal pain, heartburn, acid indigestion and acid reflux. The pathway begins in the stomach, where roxatidine a...
Betazole Action Pathway
smpdb.ca/view/SMP0000736Drug actionBetazole, also known as ametazole and Histalog, is a histamine H2 agonist that causes an increase in gastric acid secretion. Betazole is commonly used to evaluate acid production. Betazole binds to the H2 receptor to enhance the G protei...
Activation of PKC Through G Protein-Coupled Receptor
smpdb.ca/view/SMP0000749SignalingG protein-coupled receptors sense stimuli outside the cell and transmit signals across the plasma membrane. Activation of protein kinase C (PKC) is one of the common signaling pathways. When a class of GPCRs are activated by a ligand, th...
Drugs: CalciumThe Oncogenic Action of 2-Hydroxyglutarate
smpdb.ca/view/SMP0002291Disease2-Hydroxyglutarate is a compound formed from isocitric acid, a component of the TCA cycle. Isocitric acid becomes dehydrogenated by isocitrate dehydrogenase using NADP as a cofactor, and forming oxoglutaric acid. Oxoglutaric acid then fo...
The Oncogenic Action of Succinate
smpdb.ca/view/SMP0002292DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...