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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb.ca/view/SMP0000321SignalingThe adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDipyridamole Phosphodiesterase Action Pathway
smpdb.ca/view/SMP0126489Drug actionDipyridamole is a phosphodiesterase inhibitor also known as Aggrenox and Persantine, used to prevent thromboembolic events post-operation. Routes of administration fall under intravenous or oral administration. Dipyridamole inhibits aden...
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortEnsulizole
go.drugbank.com/drugs/DB11115ApprovedEnsulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. … It was demonstrated by studies that ensulizole treatment provided protection against cyclobutane pyrimidine dimers and photosensitized the formation of oxidized guanine bases after UV-A or UV-B exposure
Mixtures: OHUI SUN SCIENCE Perfect Sunblock Blue EX plus, Diamond White Oil-Free Brilliant Sun ProtectionCategories: Heterocyclic Compounds, 2-RingRegulation of Lipolysis
smpdb.ca/view/SMP0573273SignalingAdipocyte lipolysis is a highly regulated metabolic process in which triacylglycerols stored in lipid droplets are enzymatically hydrolyzed to free fatty acids and glycerol to meet systemic energy demands. This multistep cascade is orche...
Enzymes: Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2Purine Nucleoside Phosphorylase Deficiency
smpdb.ca/view/SMP0125728DiseasePurine nucleoside phosphorylase deficiency (Nucleoside phosphorylase; Immunodeficiency) is a rare disease causing severe immunodeficiency. The disease is caused by a mutation in the enzyme purine nucleoside phosphorylase. The enzyme is n...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreEnzymes: ATP-binding cassette sub-family G member 2Gout or Kelley-Seegmiller Syndrome
smpdb.ca/view/SMP0125723DiseaseGout, also called Kelley-Seegmiller syndrome, is a condition that is hereditary and causes an excess in the production of uric acid in the body. It is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase. W...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreEnzymes: ATP-binding cassette sub-family G member 2Octisalate
go.drugbank.com/drugs/DB11062ApprovedOctyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm. It is an ester of salicylic acid and 2-ethylhexanol. … Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters.
Synonyms: 2-Ethylhexyl 2-hydroxybenzoate, 2-Ethylhexyl salicylateMixtures: Cyber White Brilliant Cells Full Spectrum Brightening Uv Protector SPF 50, Secret Muse Vita Blue SunBetaine Metabolism
smpdb.ca/view/SMP0000123MetabolicBetaine (or trimethylglycine) is similar to choline (trimethylaminoethanol) but differs in choline's terminal carboxylic acid group trimethylglycine is reduced to a hydroxyl group. Betaine is obtained from diet as betaine or compounds co...
Cystathionine beta-Synthase Deficiency
smpdb.ca/view/SMP0000177DiseaseCystathionine Beta-Synthase Deficiency (CBS Deficiency; Homocystinuria) is an autosomal recessive disease caused by a mutation in the CBS gene which codes for cystathionine beta-synthase. A deficiency in this enzyme results in accumulati...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more