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Hawkinsinuria
smpdb.ca/view/SMP0000190DiseaseHawkinsinuria (4-Hydroxyphenylpyruvate Hydroxylase Deficiency) is an autosomal dominant disease caused by a mutation in the HPD gene which codes for 4-hydroxyphenylpyruvate dioxygenase. A deficiency in this enzyme results in accumulation...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Alcohol dehydrogenase 1ATyrosinemia Type I
smpdb.ca/view/SMP0125591DiseaseTyrosinemia type I, also known as fumarylacetoacetase or FAH deficiency, is the most severe type of tyrosinemia, a buildup of tyrosine in the body. It is caused by an autosomal recessive mutation in the the FAH gene that encodes for fuma...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Alcohol dehydrogenase 1AMonoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0125595DiseaseMomoamine oxidase A (MAO-A) deficiency, or Brunner syndrome, is an X-linked recessive genetic disorder caused by a mutation in the MAOA gene that encodes for monoamine oxidase A. As such it is almost exclusively found in men. MAO-A is an...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Alcohol dehydrogenase 1ATyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592DiseaseA transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. This disorder, termed neonatal tyrosinemia, was first described by Levine and Gordon in 1939. In the intervening years oth...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Alcohol dehydrogenase 1AVitamin A Deficiency
smpdb.ca/view/SMP0125788DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Enzymes: Alcohol dehydrogenase 1A, Acyl-CoA wax alcohol acyltransferase 1Vitamin A Deficiency
smpdb.ca/view/SMP0000336DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Enzymes: Alcohol dehydrogenase 1A, Acyl-CoA wax alcohol acyltransferase 1Celecoxib metabolism Pathway
smpdb.ca/view/SMP0000096MetabolicCelecoxib, a non-steroidal anti-inflammatory drug (NSAID), is a selective inhibitor of cyclooxygenase-2 (COX-2), also known as prostaglandin G/H synthase 2. Like other NSAIDs, celecoxib exerts its effects by inhibiting the synthesis of p...
Enzymes: Alcohol dehydrogenase 1B, Alcohol dehydrogenase 1ADoxorubicin Metabolism Pathway
smpdb.ca/view/SMP0000650Drug metabolismDoxorubicin is an anthracycline antibiotic used as a cancer chemotherapy drug. The major metabolic route of doxorubicin metabolism is two-electron reduction to doxorubicinol. A second route is one-electron reduction resulting in a doxoru...
Enzymes: Alcohol dehydrogenase [NADP(+)]Ethanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionEthanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally.
Cocaine metabolism
smpdb.ca/view/SMP0125265MetabolicWhen cocaine is taken with alcohol however, it metabolizes into the active metabolite cocaethylene by the hepatic enzyme carboxylesterase in the endoplasmic reticulum lumen.