Search
Sodium Depletion
go.drugbank.com/conditions/DBCOND0093130Drugs: Sodium chlorideSynonyms: Hypo-osmolality and hyponatremia, Sodium DepletionHydrochlorothiazide
go.drugbank.com/drugs/DB00999ApprovedInvestigationalVet approved[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers. … [A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.
Mixtures: Fosinopril Sodium and Hydrochlorothiazide, Fosinopril Sodium and HydrochlorothiazideCategories: Sodium Chloride Symporter Inhibitors, hydrochlorothiazide and potassiumTocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126519Drug actionTocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. … Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alphaLidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126504Drug actionIt ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding … , conduction rate, and force of contraction.
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel subunit beta-1Glutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreEnzymes: Sodium-coupled neutral amino acid transporter 5Bisacodyl
go.drugbank.com/drugs/DB09020ApprovedInvestigational[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).
Mixtures: HalfLytely and Bisacodyl, HalfLytely and BisacodylCategories: Alimentary Tract and MetabolismDaptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational) and vancomycin-resistant Enterococci (VRE). … [A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal
Categories: Amino Acids, Peptides, and ProteinsProducts: Daptomycin in Sodium ChlorideMetabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicGlyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. … Glycine and hydroxyproline comes from protein sources in the diet such as red meat and eggs. Glycine Is converted into glyoxylate in the peroxisome by the enzyme d-amino acid oxidase.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Argininic acid is a uremic toxin that is toxic to the nervous system, and it causes various neurlogical disorders such as variable degree of mental retardation, epilepsy and progressive spasticity.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicIt normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity. … An amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product.
Enzymes: Sodium/glucose cotransporter 1