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Pemetrexed Action Pathway
smpdb.ca/view/SMP0126261Drug actionOnce inside the cell via a folate transporter, it is converted to by folylpolyglutamate synthétase into its polyglutamate form. … This new form is better retained in the cells and goes on to inhibit enzymes such as dihydrofolate reductase, thymidylate synthase and bifunctional purine biosynthesis protein (PURH).
Naftifine Action Pathway
smpdb.ca/view/SMP0125827Drug actionNaftifine is an antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species. It is used as a topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rub...
Drugs: Naftifine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreRaltitrexed Action Pathway
smpdb.ca/view/SMP0126304Drug actionRaltitrexed is a folate analog that is used in the treatment of colorectal cancer, that is an inhibitor of thymidylate synthase. Inhibiting thymidylate synthase stops the proliferation of cancer cells, as it stops the production and form...
Butenafine Action Pathway
smpdb.ca/view/SMP0125811Drug actionButenafine is a topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis due to the fungi E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.The exact mechanism of action has not been est...
Drugs: Butenafine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreSepiapterin Reductase Deficiency
smpdb.ca/view/SMP0125588DiseaseSepiapterin reductase deficiency is a genetic disorder that is characterized by abnormal levels of neurotransmitters and pterins. It is caused an autosomal recessive genetic mutation in the SPR gene which leads to the underproduction of ...
Enzymes: Aromatic-L-amino-acid decarboxylaseFolate Metabolism
smpdb.ca/view/SMP0000053MetabolicFrom there, dihydrofolate reductase converts folic acid into dihydrofolic acid. Dihydrofolic acid is then created into tetrahydrofolic acid through dihydrofolate reductase. … Many countries around the world now fortify foods with folic acid to prevent such defects.
Terbinafine Action Pathway
smpdb.ca/view/SMP0125118Drug actionTerbinafine (commonly known as Lamisil or Silka cream) is a synthetic allylamine anti-fungal used mainly for athletes foot and other fungal skin infections. While Terbinafine is most commonly used against the fungus species Trichophyton ...
Drugs: Terbinafine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreTolnaftate Action Pathway
smpdb.ca/view/SMP0125360Drug actionTolnaftate is an over-the-counter anti-fungal agent mainly used to treat jock itch, athlete's foot and ringworm. It can come as a cream, powder, spray, or liquid aerosol. Tolnaftate is diffuses into the fungal cell. The exact mechanism o...
Drugs: Tolnaftate · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreMiconazole Action Pathway
smpdb.ca/view/SMP0125822Drug actionThis molecule participates in quorum sensing in Candida, preventing the transition from yeast to mycelial forms and thereby the formation of biofilms, which are more resistant to antibiotics.
Drugs: Miconazole · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreMevalonic Aciduria
smpdb.ca/view/SMP0000510DiseaseIt is manifested by high levels of mevalonic acid in the urine and other body fluids. Approximately 30 patients with mevalonic aciduria (MVA) have been reported worldwide. … MVA is classified as a disorder of branched-chain organic acid metabolism because the substrate for the reaction with mevalonate kinase, HMG-CoA, is a product of leucine catabolism.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolase