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Valine, Leucine, and Isoleucine Degradation
smpdb.ca/view/SMP0000032Metabolicand acetyl-CoA) and glucose (succinyl-CoA). … As a result, three different α-keto acids are produced and are oxidized using a common branched-chain α-keto acid dehydrogenase (BCKD), yielding the three different CoA derivatives.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialThreonine and 2-Oxobutanoate Degradation
smpdb.ca/view/SMP0000452Metabolic2-oxobutanoate, also known as 2-Ketobutyric acid, is a 2-keto acid that is commonly produced in the metabolism of amino acids such as methionine and threonine. … , and a dihydrolipoamide dehydrogenase (E3) with a flavin cofactor.
Enzymes: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialMycophenolic Acid Metabolism Pathway (old)
smpdb.ca/view/SMP0000652Drug metabolismMycophenolic Acid (MPA) is an immunosuppressive agent that acts as a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … only) and CES-2 (in the liver and intestine).
Tranexamic Acid Action Pathway (New)
smpdb.ca/view/SMP0124487Drug actionTranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site. … Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It targets plasminogen in blood vessels where these clots occur.
Mefenamic Acid NSAID Action Pathway
smpdb.ca/view/SMP0124586Drug actionMefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. It has analgesic, anti-inflammatory, and antipyretic properties. … Mefenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. … Salicylic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Tiaprofenic Acid Action Pathway (New)
smpdb.ca/view/SMP0124607Drug actionTiaprofenic acid possess anti-inflammatory, analgesic and antipyretic activity. … Tiaprofenic acid is a nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis.
Drugs: Glutathione · Dinoprostone · Calcium · Tiaprofenic acid · Mesoheme · Prostaglandin G2 +1 moreMycophenolic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174716MetabolicMetabolites of Mycophenolic acid are predicted with biotransformer.
Fatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicIn liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required. … In particular, both pathways make use of acetyl-CoA acyltransferase, 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000521Diseaseacid. … acid excreted in the urine.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial