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Displaying results 971 - 980 of 10000 in total
  1. Drug

    Bromhexine

    go.drugbank.com/drugs/DB09019
    ApprovedInvestigational

    Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. … It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.

    Mixtures: LUMOXBRON-S, SP-BROM ELIXIRSynonyms: N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine
  2. Pathway

    Selenoamino Acid Metabolism

    smpdb.ca/view/SMP0000029
    Metabolic

    Phospholipids are membrane components in P. aeruginosa. The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty...

    Drugs: Pyridoxal phosphate · Adenosine phosphate · Serine · Alanine · ATP · Adenosine +3 more
    Enzymes: S-adenosylmethionine synthase isoform type-2
  3. Drug

    Eteplirsen

    go.drugbank.com/drugs/DB06014
    ApprovedInvestigational

    Eteplirsen is a synthetic antisense oligonucleotide and a phosphorodiamidate morpholino oligomer. … is amenable to exon 51 skipping.

    Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl, )-1-piperazinyl)-N,N-dimethylphosphonamidate) RNA
  4. Drug

    V590

    go.drugbank.com/drugs/DB16437
    Experimental

    By teaming up with IAVI, Merk developed a vaccine that does not require freezing, and only requires one dose[L30583]. … Merck is currently underway to begin Phase I trials for the vaccine through intramuscular administration (NCT04569786).

  5. Pathway

    Gq Adrenergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0126882
    Physiological

    Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be refer...

    Drugs: ATP · Calcium · Magnesium cation
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  6. Indication

    Vitamin K antagonist induced major bleeding

    go.drugbank.com/conditions/DBCOND0089503
    Drugs: Coagulation factor VII human · Protein S human · Prothrombin
  7. Drug

    Halofantrine

    go.drugbank.com/drugs/DB01218
    ApprovedWithdrawn

    Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. … Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates
  8. Drug

    RAF-265

    go.drugbank.com/drugs/DB05984
    Investigational

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Lifileucel

    go.drugbank.com/drugs/DB17107
    ApprovedInvestigational

    Lifileucel is a tumour-derived autologous T cell immunotherapy composed of a suspension of tumour-derived T cells from the patient [L50171] which undergo isolation, ex vivo expansion, and activation[A263341

  10. Pathway

    Lysophosphatidic Acid LPA5 Signalling

    smpdb.ca/view/SMP0063757
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas