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Triamcinolone Action Pathway
smpdb.ca/view/SMP0126251Drug actionTriamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions. … Triamcinolone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from
Nicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
Retinol Metabolism
smpdb.ca/view/SMP0000074MetabolicRetinol is part of the vitamin A family, and is known as vitamin A1, and in a dietary context it is a type of preformed vitamin A. As with other preformed vitamin A's, it can be obtained from animal sources, with the highest concentratio...
NAD+ Signalling and Aging
smpdb.ca/view/SMP0084271SignalingAn interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1. Short-t...
Levocetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175001Drug actionLevocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. H1-antihistamines interfere with the agonist action of histamine at the...
Levocetirizine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175093Drug actionLevocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. H1-antihistamines interfere with the agonist action of histamine at the...
Vitamin A Deficiency
smpdb.ca/view/SMP0125788DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Vitamin A Deficiency
smpdb.ca/view/SMP0000336DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Levocetirizine H1-Antihistamine Action
smpdb.ca/view/SMP0059114Drug actionLevocetirizine is a second-generation piperazine H1-antihistamine. It has also been labeled as a third-generation antihistamine because it is developed from a second-generation antihistamine (cetirizine). H1-antihistamines interfere with...
NAD+ Signalling Pathway (Cancer)
smpdb.ca/view/SMP0083297SignalingNAD+-dependent signalling pathways regulate many fundamental processes such as DNA repair, DNA transcription, cell proliferation, cell survival, cell cycle progression, apoptosis, and metabolism. These pathways are all linked to cancer d...