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Indium In-111 oxyquinoline Drug Metabolism
smpdb.ca/view/SMP0130676MetabolicIndium In-111 oxyquinoline passes through the liver and is then excreted from the body mainly through the kidney. … Indium In-111 oxyquinoline is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indium In-111 oxyquinolineFatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicIn liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required. … All of the fatty acids needed by the body can be synthesized from palmitate (C16:0) except the essential, polyunsaturated fatty acids such as linoleate and linolenate.
Indium In-111 pentetate Drug Metabolism
smpdb.ca/view/SMP0130595MetabolicIndium In-111 pentetate passes through the liver and is then excreted from the body mainly through the kidney. … Indium In-111 pentetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indium In-111 pentetateFc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingThis activates the mast cells and results in degranulation, a process by which preformed granules containing histamine, proteoglycans, and serine proteases, are released. … The release of these compounds results in the inflammatory response.
The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002358DiseaseThis results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation. … The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase (IDH).
The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002359DiseaseThe compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase (IDH). … A mutation in IDH causes high concentrations of D-2-Hydroxyglutaric acid. D-2-hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
Glutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … It also macromolecule biosynthesis, glutaminolysis also has an important role in regulating redox balance, mTOR signaling, apoptosis and autophagy.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicThese compounds can be found in the diet, where the mixture of nicotinic acid and nicotinamide are called vitamin B3 or niacin. … Lastly, the nicotinic acid group is amidated to form a nicotinamide group, resulting in a molecule of nicotinamide adenine dinucleotide (NAD). Additionally, NAD can be phosphorylated to form NADP.
Fructose and Mannose Degradation
smpdb.ca/view/SMP0000064MetabolicFructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners. … Mannose in the urine can be beneficial in treating urinary tract infections caused be E. coli. However, mannose can be detrimental to humans by causing diabetic complications.
Androgen and Estrogen Metabolism
smpdb.ca/view/SMP0000068MetabolicThis means that if either of these hormones are to be “chemical signals”, their half-life in the bloodstream has to be limited so that a variation in secretion rate can be emulated in the plasma. … Inactive androgens and estrogens are mostly eliminated in the urine.