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Displaying results 1 - 10 of 209 in total
  1. Pathway

    Naltrexone Metabolism

    smpdb.ca/view/SMP0125328
    Metabolic

    Only 2% of naltrexone remains as the original naltrexone while the remainder is metabolized into 6-beta-naltrexol and other minor metabolites. … In the liver naltrexone is metabolized into 6-beta-naltrexol. It was predicted by biotransformer that Cytochrome P450 2C9 metabolizes naltrexone into 6-beta-naltrexol.

    Drugs: Naltrexone · Mesoheme
  2. Pathway

    Naltrexone Action Pathway

    smpdb.ca/view/SMP0000687
    Drug action

    Naltrexone is also a type of medication that are used for manage opioid or alcohol dependence. … Naltrexone (also known as ReVia and Vivitrol) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS).

    Drugs: ATP · Norepinephrine · Naltrexone · Dopamine · Potassium cation · Calcium
  3. Pathway

    Naltrexone Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0125274
    Drug action

    Naltrexone inhibits Mu, Kappa, and Delta opioid receptors, with the highest affinity for the mu-type opioid receptors. … The major metabolite, 6-β-naltrexol is also a opioid antagonist that may contribute to the effects of naltrexone.

    Drugs: ATP · Naltrexone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
  4. Pathway

    S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

    smpdb.ca/view/SMP0125680
    Disease

    AHCY codes for the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase) which efficiently eliminates S-adenosylhomocysteine (SAH) by catalyzing its hydrolysis into adenosine and homocysteine. … SAH is both a byproduct of S-adenosylmethionine-dependent methyltransferases and a powerful methyltransferase inhibitor.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  5. Pathway

    S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

    smpdb.ca/view/SMP0000214
    Disease

    AHCY codes for the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase) which efficiently eliminates S-adenosylhomocysteine (SAH) by catalyzing its hydrolysis into adenosine and homocysteine. … SAH is both a byproduct of S-adenosylmethionine-dependent methyltransferases and a powerful methyltransferase inhibitor.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  6. Pathway

    Metabolism and Physiological Effects of S-Adenosylhomocysteine

    smpdb.ca/view/SMP0127690
    Metabolic

    S-Adenosyl-L-homocysteine (SAH) is formed by the demethylation of S-adenosyl-L-methionine. … S-Adenosylhomocysteine forms when there are elevated levels of homocysteine and adenosine. S-Adenosyl-L-homocysteine is a potent inhibitor of S-adenosyl-L-methionine-dependent methylation reactions.

    Drugs: Ademetionine · Methionine · ATP · Potassium cation · Magnesium cation · Pyrophosphoric acid
    Enzymes: S-methylmethionine--homocysteine S-methyltransferase BHMT2, S-adenosylmethionine synthase isoform type-2
  7. Pathway

    Spermidine and Spermine Biosynthesis

    smpdb.ca/view/SMP0000445
    Metabolic

    Spermidine is subsequently processed into spermine by spermine synthase in the presence of the aminopropyl donor, S-adenosylmethioninamine. … Spermidine originates from the action of spermidine synthase, which converts the methionine derivative S-adenosylmethionine and the ornithine derivative putrescine into spermidine 5'-methylthioadenosine

    Drugs: Pyridoxal phosphate · Ademetionine · Spermine · Ornithine · Methionine · ATP +6 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-adenosylmethionine synthase isoform type-2
  8. Pathway

    Cystathionine beta-Synthase Deficiency

    smpdb.ca/view/SMP0000177
    Disease

    Cystathionine Beta-Synthase Deficiency (CBS Deficiency; Homocystinuria) is an autosomal recessive disease caused by a mutation in the CBS gene which codes for cystathionine beta-synthase. A deficiency in this enzyme results in accumulati...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  9. Pathway

    Methionine Adenosyltransferase Deficiency

    smpdb.ca/view/SMP0000221
    Disease

    Methionine adenosyltransferase (MAT; Hypermethioninemia; MAT I/III deficiency) deficiency is caused by mutations in the MAT1A gene which causes isolated hypermethioninemia. MAT catalyzes the formation of adenosylmethionine from methionin...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  10. Pathway

    Hypermethioninemia

    smpdb.ca/view/SMP0000341
    Disease

    This gene is responsible for Adenosylhomocysteinase, an enzyme which takes S-adenosyl homocysteine as input, and produces homocysteine as its output.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase