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Levocetirizine H1-Antihistamine Action
smpdb.ca/view/SMP0059114Drug actionLevocetirizine is a second-generation piperazine H1-antihistamine.
Levocetirizine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175093Drug actionLevocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
Levocetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175001Drug actionLevocetirizine inhibits the H1 histamine receptor on blood vessel endothelial cells. … Levocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
Levocetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174909Drug actionLevocetirizine also inhibits the H1 histamine receptor on bronchiole smooth muscle myocytes. … Levocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
Nicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
Retinol Metabolism
smpdb.ca/view/SMP0000074MetabolicRetinol is part of the vitamin A family, and is known as vitamin A1, and in a dietary context it is a type of preformed vitamin A. As with other preformed vitamin A's, it can be obtained from animal sources, with the highest concentratio...
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
smpdb.ca/view/SMP0000371DiseaseCongenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage enzyme. Cholesterol side-chain cleava...
Corticosterone Methyl Oxidase I Deficiency (CMO I)
smpdb.ca/view/SMP0000577DiseaseCorticosterone methyloxidase type I (CMO-I) deficiency, also known as 18-hydroxylase deficiency or aldosterone deficiency among other names, is a genetic disorder that is autosomally linked and caused by a defective CYP11B2 gene. This ge...
Apparent Mineralocorticoid Excess Syndrome
smpdb.ca/view/SMP0000717DiseaseApparent mineralocorticoid excess (AME), also known as cortisol 11-beta-ketoreductase deficiency, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by a mu...
NAD+ Signalling and Aging
smpdb.ca/view/SMP0084271SignalingAn interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1. Short-t...