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Enalaprilat

go.drugbank.com/drugs/DB09477
ApprovedInvestigational

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodiu...

  1. Drug

    Enalapril

    go.drugbank.com/drugs/DB00584
    ApprovedInvestigationalVet approved

    Ultimately, enalaprilat works to reduce blood pressure and blood fluid volume. … The active metabolite enalaprilat is also available in oral tablets and intravenous formulations for injection.

    Synonyms: Enalaprila, EnalaprilSalts: Enalapril maleate, Enalapril sodium
  2. Pathway

    Enalapril Action Pathway

    smpdb.ca/view/SMP0000148
    Drug action

    Enalapril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form enalaprilat via cleavage of its ester group by the liver. … Enalapril (trade name: Vasotec) belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension).

    Drugs: Enalapril · Potassium cation · Zinc
  3. Pathway

    Enalapril Metabolism Pathway

    smpdb.ca/view/SMP0000593
    Drug metabolism

    Enalapril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form enalaprilat via cleavage of its ester group by the liver. … Enalapril (trade name: Vasotec) belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension).

    Drugs: Enalapril · Zinc
  4. Pathway

    Enalapril ACE Inhibitor Action Pathway

    smpdb.ca/view/SMP0123086
    Drug action

    Enalapril is converted into Enalaprilat through the liver after being ingested which travels in the blood to inhibit ACE which is from the lungs. … Enalapril is an angiotensin-converting enzyme (ACE) inhibitor for the conversion of angiotensin I into angiotensin II.

    Drugs: Glutamic acid · Enalapril · Zinc
  5. Indication

    Left Ventricular Dysfunction

    go.drugbank.com/conditions/DBCOND0031407
    Drugs: Enalaprilat · Ivabradine · Quinapril · Trandolapril
  6. Indication

    Heart Failure

    go.drugbank.com/conditions/DBCOND0027920
    Drugs: Alteplase · Atenolol · Benazepril · Bisoprolol · Captopril · Enalaprilat +10 more
  7. Indication

    Diabetic Nephropathy

    go.drugbank.com/conditions/DBCOND0028920
    Drugs: Benazepril · Candesartan cilexetil · Captopril · Enalapril · Enalaprilat · Eprosartan +9 more
  8. Indication

    Hypertension

    go.drugbank.com/conditions/DBCOND0020037
    Drugs: Acebutolol · Aliskiren · Amiloride · Amlodipine · Ammonium chloride · Aprocitentan +78 more