Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 2026 - 2050 of 15154 in total

Mephenytoin

Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome...
Approved
Investigational
Withdrawn
Matched Iupac: … 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione …
Matched Description: … Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias ... Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and …

Metaxalone

Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone...
Approved
Matched Iupac: … 5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one …
Matched Description: … Metaxalone is associated with few side effects and is available as a 800 mg scored tablet. ... muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and …

Methdilazine

Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Approved
Matched Iupac: … 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine …

Pentaerythritol tetranitrate

Pentaerythritol tetranitrate is the nitrate ester of pentaerythritol that possesses explosive properties. When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina . It is a pentaerythritol nitrate in...
Approved
Matched Iupac: … 3-(nitrooxy)-2,2-bis[(nitrooxy)methyl]propyl nitrate …
Matched Description: … that is stored and shipped as a mixture with water and alcohol [L2394]. ... It is also one of the most powerful high explosives known and is a component of the plastic explosive ... It is formed by reacting pentaerythritol (C5H12O4), an alcohol commonly used in paints and varnishes, …

Iopanoic acid

Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
Approved
Withdrawn
Matched Iupac: … 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid …
Matched Description: … Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. …

Ponatinib

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Approved
Investigational
Matched Iupac: … 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Amorolfine

Amorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol to accumulate in the fungal cytoplasmic cell membranes. Amorolfine is marketed as Curanail, Loceryl, Locetar, and Odenil. It is available...
Approved
Investigational
Matched Iupac: … (2R,6S)-2,6-dimethyl-4-(2-{[4-(2-methylbutan-2-yl)phenyl]methyl}propyl)morpholine …
Matched Description: … It is available in the form of a 5% amorolfine nail lacquer used to treat onychomycosis (fungal infection ... of the toe- and fingernails). ... Amorolfine is marketed as Curanail, Loceryl, Locetar, and Odenil. …

Aldesleukin

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from...
Approved
Matched Description: … Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression ... This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Iupac: … (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.0 …
Matched Description: … [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. ... The effect of this drug has no homology in human host cells, which gives it excellent tolerability and …
Matched Categories: … lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …

Chondroitin sulfate

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine...
Approved
Investigational
Nutraceutical
Matched Description: … [A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long ... Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic ... acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific …
Matched Mixtures name: … Blackmores Joint Formula with Glucosamine and Chondroitin …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)

Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) is a vaccine that contains inactivated acellular pertussis antigen that is isolated from Bordetella pertussis culture.
Approved
Investigational
Matched Mixtures name: … FILAMENTOUS HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS PERTACTIN ANTIGEN, and …

Palifermin

Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004.
Approved
Matched Description: … It is 140 residues long, and is produced using E. coli. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Vidarabine

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus.
Approved
Investigational
Matched Description: … viruses, the vaccinia VIRUS and varicella zoster virus. ... It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures ... and significant antiviral activity against infections caused by a variety of viruses such as the herpes …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Lapyrium

Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products . It is commonly found formulated as lapyrium chloride.
Approved
Matched Iupac: … 1-({[2-(dodecanoyloxy)ethyl]carbamoyl}methyl)pyridin-1-ium …
Matched Description: … Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various …

Meradimate

Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter. It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an...
Approved
Matched Iupac: … 5-methyl-2-(propan-2-yl)cyclohexyl 2-aminobenzoate …
Matched Description: … Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products …
Matched Mixtures name: … Principal Secret Reclaim Sunscreen For Face and Body SPF 30 …

Guanoxan

Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage. Guanoxan was approved in the UK but was withdrawn from the market due to hepatotoxicity.
Approved
Matched Iupac: … N-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]guanidine …

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative ... possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become …
Matched Categories: … Alimentary Tract and Metabolism …

Olipudase alfa

Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Description: … [A251590] It is the first and only enzyme replacement therapy in the world for the treatment of Acid ... to hydrolyze sphingomyelin accumulated in body tissues, such as the lungs, liver, spleen, kidneys, and ... [A251590] It was later approved by the European Commission on June 28, 2022 [L42740] and by the FDA on …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Alteplase

Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.[A252330,L43125] Alteplase...
Approved
Investigational
Matched Description: … [L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots ... alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and ... thrombolytic agents derived from tissue plasminogen activator, such as [desmoteplase], [tenecteplase] and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Stem bromelain

The primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the brand name Nexobrid [FDA Label]. Bromelain itself belongs to a category of protein-digesting enzymes that are...
Approved
Investigational
Matched Description: … Although both fruit and stem bromelain are prepared differently and contain different enzymatic compositions ... The primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn ... wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the brand …
Matched Categories: … Enzymes and Coenzymes …

Hexaminolevulinate

Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for Intravesical Solution, Photocure ASA), as...
Approved
Matched Description: … In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an ... Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Enoxaparin

Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients...
Approved
Matched Description: … Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various ... Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …

Fosamprenavir

Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Approved
Matched Categories: … Amprenavir and Prodrugs …

Loteprednol etabonate

Loteprednol Etabonate (LE) is a topical corticoid anti-inflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, it can...
Approved
Matched Description: … As a nasal spray, it can be used for the treatment and management of seasonal allergic rhinitis. ... , uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and ... prescription LE products, however, tend to be indicated for the treatment of post-operative inflammation and …

Flecainide

Flecainide is a Class I anti-arrhythmic agent like encainide and propafenone. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA...
Approved
Withdrawn
Matched Iupac: … N-[(piperidin-2-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide …
Matched Description: … fibrillation and flutter. ... Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. ... [A186880] Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate …
Displaying drugs 2026 - 2050 of 15154 in total