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Displaying drugs 2776 - 2800 of 9611 in total

Trimebutine

Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI...
Approved
Matched Description: … disorders, with IBS being one of the most common multifactorial GI disorders [A19691]. ... It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility …
Matched Products: … BUMETIN(R) TABLETASRETARD 300MG …

Ranitidine

Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as...
Approved
Withdrawn
Matched Description: … [L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries. ... This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of ... [A176843] Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of …
Matched Products: … NEOCEPTIN R-150 TABLET 150 mg …

Elagolix

Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the first and only...
Approved
Investigational
Matched Description: … As of 24 July 2018, however, the U.S. ... Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis ... It has been determined that endometriosis is one of the most common gynecologic disorders in the United …

Racepinephrine

Racepinephrine is a racemic mixture consisting of d-DB00668 and l-DB00668 enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingredient in...
Approved
Matched Description: … wheezing, tightness of chest and shortness of breath. ... It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including ... Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. …
Matched Mixtures name: … Super Sulpak R 45 ... Super Sulpak R 46 ... Super Sulpak R 44 …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … However its mechanism of action differ from that of endogenous GABA. ... shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … CIPROBAY(R) 500 ... CIPROBAY (R) (250) ... CINEPRIDE(R) 500 MG TABLETAS …

Cinchocaine

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Approved
Vet approved
Matched Description: … It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is ... A local anesthetic of the amide type now generally used for surface anesthesia. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Thiamylal

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Approved
Vet approved
Matched Description: … A barbiturate that is administered intravenously for the production of complete anesthesia of short duration ... , for the induction of general anesthesia, or for inducing a hypnotic state. …
Matched Categories: … combinations of barbiturates …

Dexfenfluramine

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Approved
Illicit
Investigational
Withdrawn
Matched Description: … However, following multiple concerns about the cardiovascular side-effects of the drug, such approval ... For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Norgestrel

Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active.
Approved
Matched Description: … Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Lithium carbonate

Lithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Approved
Matched Description: … Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651, …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Nefazodone

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with...
Approved
Withdrawn
Matched Description: … On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. ... Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) ... Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Enasidenib

Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible for this treatment...
Approved
Investigational
Matched Description: … Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory ... This small molecule acts as an allosteric inhibitor of mutant IDH2 enzyme to prevent cell growth, and ... Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood …

Dantron

Withdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.
Approved
Investigational
Withdrawn

Ritonavir

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a...
Approved
Investigational
Matched Description: … American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America ... Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. ... It is now more commonly used as a booster of other protease inhibitors and is available in both liquid …
Matched Mixtures name: … ANCEF ® R ... ZANAVIR-R ... ANCEF ® R …
Matched Categories: … Antivirals for treatment of HCV infections ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative ... synthesized in 1929[A178081], investigations regarding its possible use as a laxative for the treatment of ... Essential Medicines as one of the most effective and safe medicines employed in a health system[L6205 …
Matched Products: … Comalose R Sirop 10gm/15ml …

Sulfamethizole

A sulfathiazole antibacterial agent.
Approved
Investigational
Vet approved
Matched Categories: … combinations of sulfonamides …

Zotepine

Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's. Zotepine was never approved by the FDA. In 1993,...
Approved
Investigational
Withdrawn
Matched Description: … inactive drug substance (Status I, Type II) and in 1995 the FDA studied the manufacturing procedures of ... In the EMA, by 2015 it was under pharmacovigilance studies for the potential treatment of acute renal ... [L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pibrentasvir

Pibrentasvir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS5A inhibitor that targets the the viral RNA replication and viron assembly. In combination with DB13879, pibrentastiv is a useful therapy for patients who experienced therapeutic failure from other NS5A inhibitors. In cell cultures, the emergence of amino...
Approved
Investigational
Matched Description: … treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [FDA Label]. ... In cell cultures, the emergence of amino acid substitutions at known NS5A inhibitor resistance-associated ... The ultimate goal of the combination treatment is to achieve sustained virologic response (SVR) and cure …
Matched Categories: … Antivirals for treatment of HCV infections …

Alfentanil

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Description: … A short-acting opioid anesthetic and analgesic derivative of fentanyl. ... It produces an early peak analgesic effect and fast recovery of consciousness. ... Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Amantadine

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. ... An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. ... The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Naratriptan

Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … It is typically used for the treatment of migraine headaches. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Isotretinoin

Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. …
Matched Categories: … Retinoids for Treatment of Acne …

Oxymorphone

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia,...
Approved
Investigational
Vet approved
Matched Description: … An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough ... It is used in the treatment of moderate to severe pain, including pain in obstetrics. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ergometrine

An ergot alkaloid with uterine and vascular smooth muscle contractile properties.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 2776 - 2800 of 9611 in total