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Displaying drugs 2851 - 2875 of 9732 in total

Clascoterone

Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and...
Approved
Investigational
Matched Description: … Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. ... [A218846] In August 2020, FDA approved clascoterone for the first-in-class topical treatment of acne …

Amcinonide

Amcinonide is a corticosteroid.
Approved
Matched Iupac: … 2-[(1'S,2'S,4'R,8'S,9'S,11'S,12'R,13'S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro …

Fedratinib

Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019.
Approved
Investigational
Matched Categories: … combinations of sulfonamides …

Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Approved
Investigational
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Daclatasvir

Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hepatitis C is an infectious liver disease...
Approved
Investigational
Matched Description: … substitutions that led to reduced susceptibility to daclatasvir therapy occured at position Q30 (Q30H/K/R) ... Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and ... According to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is …
Matched Categories: … Antivirals for treatment of HCV infections …

Letrozole

Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like exemestane and anastrozole, meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole was granted FDA approval on 25 July 1997.
Approved
Investigational
Matched Products: … LEZORIA (R) LETROZOL TABLETAS 2.5 MG …

Carboxymethylcellulose

Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity modifier or thickener and emulsifier. It is also one of the most common viscous polymers used in...
Approved
Investigational
Matched Description: … Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose ... in the treatment of aqueous tear-deficient dry eye symptoms and ocular surface staining [A33029]. ... It is also one of the most common viscous polymers used in artificial tears, and has shown to be effective …
Matched Products: … Cho-A Derm-R …

Sodium oxybate

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy. It is a sodium salt of gamma-Hydroxybutyric acid, an endogenous cerebral inhibitory neurotransmitter and a metabolite of the inhibitory neurotransmitter GABA. Due to its physiological effects, sodium oxybate is...
Approved
Matched Description: … [A251445] and a metabolite of the inhibitory neurotransmitter GABA. ... [L30598] An extended-release oral suspension formulation of sodium oxybate for narcolepsy, marketed ... [L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter …

Solifenacin

Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004.
Approved
Matched Description: … [L7511] It has a long duration of action as it is usually taken once daily. …

Pravastatin

Pravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved...
Approved
Matched Description: … Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. ... The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation …

Pozelimab

CD55-deficient protein-losing enteropathy (PLE), or CHAPLE disease, is an ultra-rare hereditary disease, with fewer than 100 patients diagnosed worldwide or fewer than 10 patients in the US. The pathophysiology of this disease is mainly attributed to the deficiency of the CD55 protein, which is the main regulator of the complement...
Approved
Investigational
Matched Description: … [L47850] In August 18, 2023, pozelimab was approved by the FDA for the treatment of CHAPLE disease. ... [L47880] The pathophysiology of this disease is mainly attributed to the deficiency of the CD55 protein ... , which is the main regulator of the complement cascade. …

Fenfluramine

Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712,...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life ... in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lisuride

An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists).
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tinidazole

A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Approved
Investigational
Matched Categories: … combinations of imidazole derivatives …

Fluocinolone acetonide

Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetonide was developed by Taro...
Approved
Investigational
Vet approved
Matched Description: … [T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Rizatriptan

Rizatriptan is a second-generation triptan and a selective 5-HT1B and 5-HT1D receptor agonist. Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. Rizatriptan is available in oral tablets, orally disintegrating tablets (wafers), and oral film formulations.
Approved
Matched Description: … [L46018] Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Elvitegravir

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Description: … of the viral infection. ... On September 24, 2014, the FDA approved the single pill form of elvitegravir. ... immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Dienogest

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Description: … It is a derivative of 19-nortestosterone and has antiandrogenic properties. ... , dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of ... Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Quizartinib

Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated with other targets in mind. Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although...
Approved
Investigational
Matched Description: … and thus poorer overall survival and higher risk of relapse. ... [L47426] FLT3-ITD mutation is present in 75% of FLT3-mutated AML, leading to constitutively active FLT3 ... as QT prolongation necessitates further research to optimize quizartinib's addition to AML standard of …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … KLACID (R) MR …

Docetaxel

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … different types of cancer, including breast, ovarian, and non-small cell lung cancer. ... Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of …
Matched Products: … DOCETAXEL SANDOZ (R)80 MG …

Fluocortolone

Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Approved
Withdrawn
Matched Mixtures name: … เชริพร็อค(R) เอ็น …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Description: … of the Alzheimer's type. ... Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia …

Umeclidinium

Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less...
Approved
Matched Description: … by the abundance of the muscarinic subtype 3 (M3) in the airway smooth muscle. ... Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of ... , and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than 80%. …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … [A182186] Currently approved for the treatment of depression, schizophrenia, and agitation associated …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 2851 - 2875 of 9732 in total