Displaying drugs 326 - 350 of 8039 in total
Valsartan
Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Description: … cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression of ... activity, regardless of where or how it was synthesized. ... angiotensin I to angiotensin II through inhibition of the ACE enzyme. …
Triamterene
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... in the distal part of the nephron in the kidneys by working on the lumenal side. ... It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion …
Cariprazine
Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Cariprazine has been investigated in a variety of psychiatric disorders,...
Approved
Investigational
Matched Description: … [L40198] Cariprazine has been investigated in a variety of psychiatric disorders, including schizophrenia …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Atogepant
Atogepant is an oral antagonist of calcitonin gene-related peptide (CGRP) receptors indicated for the prevention of episodic migraine headaches. It was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021. While its approval was predated by two other members of the same drug family,...
Approved
Investigational
Matched Description: … prevention of episodic migraine headaches. ... [propranolol]), all of which can be associated with significant adverse effects. ... Atogepant is an oral antagonist of calcitonin gene-related peptide (CGRP) receptors indicated for the …
Saquinavir
Saquinavir is an HIV-1 protease inhibitor used in combination with ritonavir and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a...
Approved
Investigational
Matched Description: … protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of ... a potent enzyme inhibitor - that increases the bioavailability and subsequent serum concentrations of ... oral bioavailability (approximately 4%),[L3450] its current indications require the co-administration of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Gemfibrozil
Gemfibrozil is a fibric acid agent, similar to clofibrate, used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA approval on 21...
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Dehydrocholic acid
Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Approved
Investigational
Matched Description: … It has been used for stimulation of biliary lipid secretion. ... Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with ... The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada. …
Brincidofovir
Brincidofovir is an oral antiviral drug used in the treatment of human smallpox infections. It is a lipid conjugate pro-drug of the acyclic nucleotide analogue cidofovir[L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and significantly reduces the nephrotoxicity typically associated with cidofovir therapy.[A235725,A235735] Due to its...
Approved
Investigational
Matched Description: … Brincidofovir is an oral antiviral drug used in the treatment of human smallpox infections. ... It is a lipid conjugate pro-drug of the acyclic nucleotide analogue [cidofovir][L34404,A235725] - this ... DNA viruses,[A235725] resulting in brincidofovir being investigated for the prevention and treatment of …
Diazepam
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and...
Approved
Illicit
Investigational
Vet approved
Matched Description: … It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of ... development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled ... Its actions are mediated by enhancement of gamma-aminobutyric acid activity. …
Hydroxyurea
Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea...
Approved
Matched Description: … therapeutic monitoring, and serious side effects of secondary cancer and birth defects. ... [A262596] It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. ... is used sparingly in clinical settings, largely due to lack of knowledge and adherence, the need for …
Palbociclib
Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery that identified the cyclin-dependent kinases as...
Approved
Investigational
Matched Description: … [L5867] It was originally FDA approved on March 2015 for the treatment of HR-positive, HER2-negative ... It is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine ... developed by Pfizer Inc after the discovery that identified the cyclin-dependent kinases as key regulators of …
Tetrabenazine
A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Approved
Investigational
Matched Description: … A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various ... It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease …
Oleic Acid
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Approved
Investigational
Vet approved
Matched Description: … It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. …
Ataluren
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk. More specifically, ataluren is used in the small group of patients whose...
Approved
Investigational
Matched Description: … More specifically, ataluren is used in the small group of patients whose disease is caused by a specific …
Omeprazole
Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class,...
Approved
Investigational
Vet approved
Matched Description: … reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of ... drug was the first clinical useful drug in its class, and its approval was followed by the formulation of …
Sulbactam
Sulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.
Approved
Matched Description: … Sulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. …
Fomepizole
Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Approved
Vet approved
Matched Description: … steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. ... Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial …
Idebenone
Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). It has been proposed that by interacting with the ETC, idebenone increases ATP production required for mitochondrial function, reduces free radicals, inhibits lipid peroxidation, and...
Approved
Investigational
Matched Description: … and essential component of the Electron Transport Chain (ETC). ... Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant ... More specifically, idebenone is thought to transfer electrons directly to complex III of the mitochondrial …
Cetyl alcohol
Cetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. It can be produced from the reduction of palmitic acid. Cetyl alcohol is present in a waxy white powder or flake form at room temperature, and is insoluble in water and...
Approved
Matched Description: … of total alcohols and not less than 94 percent of straight chain alcohols [L1824]. ... It can be produced from the reduction of palmitic acid. ... Discovered by Chevrenl in 1913, cetyl alcohol is one of the oldest known long-chain alcohol [A32209]. …
Betrixaban
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals...
Approved
Investigational
Matched Description: … non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of ... VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable …
Nusinersen
An antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.
Approved
Investigational
Matched Description: … FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy …
Besilesomab
Besilesomab is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis [FDA Label]. Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and use in various European countries like...
Approved
Matched Description: … monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of …
Vancomycin
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of...
Approved
Matched Description: … As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment ... option available for the the treatment of _Clostridium difficile_ associated diarrhea and enterocolitis …
Ifosfamide
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Approved
Matched Description: … Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of …
Ubidecarenone
Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation. The ubidecarenone is...
Approved
Investigational
Nutraceutical
Matched Description: … From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of ... destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of …
Displaying drugs 326 - 350 of 8039 in total