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Displaying drugs 351 - 375 of 10409 in total

Imipramine

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression ... Adrenergic Agents ... Serotonin Agents …

Minaprine

Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Approved
Matched Description: … Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity …
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Agents that produce hypertension ... Central Nervous System Agents ... Agents that reduce seizure threshold …

Peginterferon beta-1a

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … [L31428] Currently, it is the only approved pegylated interferon for the management of MS with an proven ... It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular ... [A176474,L5792] Peginterferon beta-1a is an interferon therapy used for the management of relapsing …
Matched Categories: … Pegylated agents ... Immunosuppressive Agents ... Myelosuppressive Agents ... Antineoplastic and Immunomodulating Agents …

Acebutolol

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Approved
Investigational
Matched Categories: … Adrenergic Agents ... Autonomic Agents ... Antiarrhythmic agents ... Hypotensive Agents ... Antihypertensive Agents …

Strontium chloride

Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession [A33167, A33168]. This kind of barrier protection for tooth hypersensitivity has, however, been...
Approved
Matched Description: … however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents …

Bismuth subgallate

Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet...
Approved
Matched Description: … Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration ... yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an …
Matched Categories: … Anti-Infective Agents ... Hematologic Agents ... Neurotoxic agents …

Lemborexant

Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance. Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits,...
Approved
Investigational
Matched Description: … is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an ... [A189006] This novel mechanism of action offers potential advantages over classic hypnotic agents, including …
Matched Categories: … Central Nervous System Agents ... Neurotransmitter Agents …

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Description: … It was initially approved by the FDA in 1991 [A174175]. ... macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... QTc Prolonging Agents ... Photosensitizing Agents ... Moderate Risk QTc-Prolonging Agents …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … was established via appending hydroxylaminobutyric acid to [DB12604] at position 1 and 2-hydroxyethyl group ... On June 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment …
Matched Categories: … Anti-Bacterial Agents ... Nephrotoxic agents ... Agents that produce neuromuscular block (indirect) …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … [L6814] This drug was approved by the FDA on February 12, 2018. ... [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to ... in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion channel …

Sodium carbonate

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.
Approved
Matched Description: … As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid. …

Flucloxacillin

Antibiotic analog of cloxacillin.
Approved
Investigational
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents …

Chloroprocaine

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of...
Approved
Investigational
Matched Description: … [A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 ... Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride ... [A252952] Chloroprocaine can be given as an injection, and is available in formulations with and without …
Matched Categories: … Sensory System Agents ... Central Nervous System Agents ... Peripheral Nervous System Agents …

Barium sulfate

Barium sulfate is an inorganic compound with the chemical formula BaSO4 . Barium sulfate occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield . This drug is used as a contrast agent in...
Approved
Matched Description: … Barium sulfate is an inorganic compound with the chemical formula BaSO4 [L1957]. …
Matched Categories: … barium sulfate with suspending agents ... barium sulfate without suspending agents …

Bordetella pertussis toxoid antigen (formaldehyde inactivated)

Bordetella pertussis toxoid antigen (formaldehyde inactivated) is a vaccine.
Approved

Olanzapine

Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent ... [T554] It was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996. …
Matched Categories: … Antidepressive Agents ... Autonomic Agents ... Antipsychotic Agents ... Anticholinergic Agents ... Serotonin Agents …
Matched Products: … Truemed Group LLC …

Naldemedine

Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of DB00704 to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and...
Approved
Investigational
Matched Description: … Naldemedine is an opioid receptor antagonist [FDA Label]. ... Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation …

Calcium glubionate anhydrous

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved

Chlorquinaldol

Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment...
Approved
Matched Description: … [F4549] It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa ... Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene …
Matched Categories: … Anti-Infective Agents ... Anti-Infective Agents, Local …

Lyme disease vaccine (recombinant OspA)

Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as...
Approved
Withdrawn
Matched Description: … It is conjugated with alum (aluminum hydroxide) as an adjuvant. ... Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi …

Ketorolac

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain,...
Approved
Matched Description: … tablet, injectable, nasal spray and as an ophthalmic solution. ... Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral …
Matched Categories: … Nephrotoxic agents ... Antirheumatic Agents ... Anti-Inflammatory Agents ... Agents causing hyperkalemia ... Photosensitizing Agents …

Vemurafenib

Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann...
Approved
Matched Categories: … Antineoplastic Agents ... QTc Prolonging Agents ... Photosensitizing Agents ... Antineoplastic and Immunomodulating Agents ... Highest Risk QTc-Prolonging Agents …

Samarium (153Sm) lexidronam

Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium...
Approved
Investigational
Matched Description: … Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the …
Matched Categories: … Sensory System Agents ... Central Nervous System Agents ... Peripheral Nervous System Agents ... Pain Palliation (Bone Seeking Agents) …

Fidaxomicin

Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by Clostridioides (formerly Clostridium) difficile in adult and pediatric patients over the age of 6 months. Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation. Because fidaxomicin contains an 18-membered lactone ring in its structure, it is...
Approved
Matched Description: … [A190501] Because fidaxomicin contains an 18-membered lactone ring in its structure, it is referred to ... [A190492] Later that year in December, the drug was also approved by the European Medicine Agency. ... [A190486] The approved indication of fidaxomicin was expanded by the FDA in January 2020 to include pediatric …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents …

Clonazepam

A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being...
Approved
Illicit
Matched Categories: … GABA Agents ... Central Nervous System Agents ... Muscle Relaxants, Centrally Acting Agents …
Displaying drugs 351 - 375 of 10409 in total