Displaying drugs 4051 - 4075 of 8039 in total
(R)-warfarin
Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.
Experimental
Matched Description: … Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared …
Prezatide
Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer...
Experimental
Matched Description: … Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex …
Prezatide copper
Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer...
Experimental
Matched Description: … Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex …
Benidipine
Benidipine has the formula 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride. It is a synthetic dihydropyridine derivative that has anti-hypertensive and anti-anginal actions. It was originated in Japan by Kyowa Hakko, it is submitted for FDA approval and it is currently available in some Asian countries like India and Japan.[L1385, L1386]
Experimental
Dirithromycin
Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.
Experimental
Matched Description: … Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial …
Vanoxerine
Vanoxerine is a highly selective dopamine transporter antagonist. It was synthesized in the late 1970s and developed as a potential treatment for depression. Vanoxerine was later evaluated as a potential treatment for cocaine addiction due to its ability to block dopamine reuptake with a slower dissociation rate than cocaine. Although...
Investigational
Matched Description: … [A37914] Although several studies have suggested that the profile of vanoxerine is safer than that of …
Oxabolone cipionate
Oxabolone cipionate is the C17β cypionate ester and a prodrug of DB01500. A synthetic anabolic-androgenic (AAS) steroid, it is a derivative of 19-nortestosterone (nandrolone). It is considered as a performance enhancing drug thus is prohibited from use in sports.
Experimental
Matched Description: … Oxabolone cipionate is the C17β cypionate ester and a prodrug of [DB01500]. ... A synthetic anabolic-androgenic (AAS) steroid, it is a derivative of 19-nortestosterone (nandrolone). …
Azosemide
Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.
Investigational
Seletracetam
Seletracetam is a pyrrolidone derivative and with a structural similarity to newer generation antiepileptic drug levetiracetam. It binds to the same target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of acquired and genetic epilepsy with high CNS tolerability. It is predicted to have...
Investigational
Matched Description: … As of 2010, its production was further halted due to the investigation of a newer antiepileptic agent ... Seletracetam was in Phase II clinical trials under the supervision of the U.S. ... target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of …
Propacetamol
Propacetamol is a non-opioid analgesic devoid of the major contraindications. It is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely hydrolyzed to paracetamol. It is not available in...
Experimental
Matched Description: … Propacetamol is a non-opioid analgesic devoid of the major contraindications. ... [A32051] It is a derivative of [acetaminophen], or paracetamol, with the molecular formula glycine, N ... Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely …
Cannabidivarin
Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within DB14009. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana . Compared to its homolog, DB09061, CBDV is shortened by two methyl (CH2) groups...
Investigational
Matched Description: … a large family of ion channels that are involved in the onset and progression of several types of epilepsy ... While the primary components of cannabis, CBD and THC, have been shown to modulate many of their physiological ... activity of cannabis, or marijuana [A32584]. …
Icaridin
Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of the piperidine chemical family. Piperidines are structural components of piperine, which is a plant extract from the genus _Piper _, or pepper. Icaridin has been commonly used as a topically-applied insect repellent...
Experimental
Matched Description: … It is considered to be the first choice of repellent by the Public Health Agency of Canada’s Canadian ... known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of ... Piperidines are structural components of [piperine], which is a plant extract from the genus _Piper _ …
Banoxantrone
Banoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic to, hypoxic cells in tumours. It has been shown to work synergistically with fractionated radiation to significantly delay growth of tumours compared to administration of either banoxantrone or radiation alone. Banoxantrone was also efficacious in...
Investigational
Matched Description: … tumours compared to administration of either banoxantrone or radiation alone. ... It has been shown to work synergistically with fractionated radiation to significantly delay growth of …
Azelnidipine
Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unlike some other calcium channel blockers . It is currently being...
Investigational
Matched Description: … It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a …
Vatalanib
Vatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.
Investigational
Matched Description: … Vatalanib is under investigation for the treatment of solid tumors. …
Arotinolol
Arotinolol is an alpha- and beta-receptor blocker developed in Japan. It is a thiopropanolamine with a tertiary butyl moiety. It has been studied for its potential to be an antihypertensive therapy. Artinolol is being developed by Sumitomo Pharmaceutical Co., Ltd. and it is currently under clinical trials.
Investigational
(S)-camphor
(S)-camphor, or L(-)-Camphor, is a stereoisomer of DB01744, a bicyclic monoterpene known to potentiate both heat and cold sensations . (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition . DB01744 is isolated from the wood of the camphor laurel tree, Cinnamomum camphora, and...
Experimental
Matched Description: … history of medicinal use. ... (S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate ... [DB01744] is isolated from the wood of the camphor laurel tree, _Cinnamomum camphora_, and had a long …
Diloxanide
Diloxanide (as Diloxanide furoate) is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections. Although it is not currently approved for use in the United States, it was approved by a CDC study in the treatment of 4,371 cases of Entamoeba histolytica from 1977...
Experimental
Matched Description: … 4,371 cases of Entamoeba histolytica from 1977 to 1990. ... Diloxanide (as [Diloxanide furoate]) is an anti-protozoal drug used in the treatment of Entamoeba histolytica ... not currently approved for use in the United States, it was approved by a CDC study in the treatment of …
Curcumin sulfate
Experimental
Brecanavir
Brecanavir (VX-385) an orally active aspartic protease inhibitor (PI), under investigation by Vertex and GlaxoSmithKline for the treatment of HIV. In July 2006, Vertex indicated that it expected GSK to initiate phase III trials of the drug in 2007. In December of 2006 GSK announced a decision to discontinue the...
Investigational
Matched Description: … of HIV. ... In December of 2006 GSK announced a decision to discontinue the development of brecanavir for the treatment ... The decision was based on issues regarding the formulation of the drug. …
Grapiprant
Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class...
Investigational
Vet approved
Matched Description: … [A39816] This class of drugs was defined in 2013 by the World Health Organization. ... [A39838] This type of molecules is currently in development for veterinary patients. ... These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic …
Metenkefalin
Metenkefalin is an endogenous opioid and beta-endorphin. It has been shown to reduce chromosomal abberations in patients with multiple sclerosis. Metenkefalin, along with tridecactide, are under investigation as an immunomodulatory therapy for moderate to severe COVID-19.[L13874,L13877]
Investigational
Camostat
Camostat mesylate, or FOY-305, is a synthetic serine protease inhibitor.[A193842,A193848] It was first described in the literature in 1981, as part of research on the inhibition of skin tumors in mice. Camostat mesylate inhibits cholecystokinin, pro-inflammatory cytokines, and serine proteases, leading to it being investigated for multiple indications including the...
Experimental
Matched Description: … of skin tumors in mice. ... [A193842,A193848] It was first described in the literature in 1981, as part of research on the inhibition ... serine proteases, leading to it being investigated for multiple indications including the treatment of …
Brotizolam
Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Brotizolam has similar effects to short-acting benzodiazepines such as triazolam. Brotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. Brotizolam is an extremely potent...
Investigational
Withdrawn
Matched Description: … Brotizolam is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. ... Brotizolam is an extremely potent drug and it is rapidly eliminated with an average half-life of 4.4 …
Displaying drugs 4051 - 4075 of 8039 in total