Displaying drugs 451 - 475 of 8033 in total
Ozenoxacin
To date, ozenoxacin has been used in trials studying the treatment of impetigo.
As of December 11, 2017 the FDA approved Ferrer Internacional S.A.'s Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by Staphylococccus aureus or Streptococcus pyogenes in adult and pediatric patients...
Approved
Investigational
Matched Description: … As of December 11, 2017 the FDA approved Ferrer Internacional S.A.' ... To date, ozenoxacin has been used in trials studying the treatment of impetigo. ... s Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by …
Diloxanide furoate
Approved
Tafasitamab
Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytotoxicity relative to non-engineered anti-CD19...
Approved
Investigational
Matched Description: … results in the lysis of B-cells (both healthy and malignant). ... Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of ... [L15292,A191829]
The CD19 surface protein is highly expressed on the surface of B-cells, where it …
Birch bark extract
Birch bark extract is rich in triterpenoids with beneficial biological and pharmacological activities. Some of the compounds identified in it include betulin, lupeol, betulinic acid, oleanolic acid, and erythrodiol. Birch bark extract is obtained from the white part of the birch tree bark, and the main species of trees used...
Approved
Experimental
Matched Description: … [L42380] Two oleogel formulations of birch bark extract (Oleogel-S10, 10% of triterpene dry extract in ... wounds in patients with epidermolysis bullosa (EB), a rare group of hereditary disorders of the skin ... [L42365,L42370] Filsuvez, one of these two formulations, is approved for the treatment of partial thickness …
Mebendazole
A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]
Approved
Vet approved
Matched Description: … A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of …
Procaterol
A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.
Approved
Investigational
Nalmefene
Nalmefene, a 6-methylene analogue of naltrexone, is an opioid receptor antagonist. It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor. In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence. Nalmefene...
Approved
Investigational
Withdrawn
Matched Description: … Nalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist. ... [L40684] The nasal spray formulation of nalmefene was approved by the FDA in May 2023.[L46511] ... It is used for complete or partial reversal of opioid drug effects, including respiratory depression, …
Filgrastim
Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in E. Coli. Human...
Approved
Matched Description: … action of the drug. ... Filgrastim mimics the biological actions of G-CSF to increase the levels of neutrophils in the blood. ... [L40719] It has a number of therapeutic uses, including the management and prevention of infections and …
Emapalumab
Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority review and breakthrough...
Approved
Investigational
Matched Description: … [A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority review ... [L4840] As well, emapalumab was given the status of PRIME by the EMA.[L4845] …
Glycopyrronium
Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the...
Approved
Investigational
Vet approved
Matched Description: … [A233570,L33090] Later research, taking advantage of the systemic distribution of muscarinic receptors ... [L33110] It is one of the most commonly prescribed anticholinergic medications. ... Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. …
Fluocinonide
A topical glucocorticoid used in the treatment of eczema.
Approved
Investigational
Matched Description: … A topical glucocorticoid used in the treatment of eczema. …
Canagliflozin
Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label].
It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018...
Approved
Matched Description: … for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type ... Cardiovascular disease is the most common cause of death in these patients [A177083]. ... also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of …
Velmanase alfa
Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex...
Approved
Investigational
Matched Description: … The resulting accumulation of sugars in the body leads to an array of clinical manifestations leading ... alpha-mannosidase for the treatment of alpha-mannosidosis. ... Commission in March 2018 under the market name Lamzede [L39754] as the first human recombinant form of …
Lepirudin
Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in Hirudo medicinalis leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on...
Approved
Withdrawn
Matched Description: … This activates endothelial cells and platelets and enhances the formation of thrombi. ... [A246609] Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012.[L41574] ... L41539] Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of …
Pitavastatin
Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Description: … studies to significantly reduce the risk of development of CVD and all-cause mortality. ... and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes ... This is the third step in a sequence of metabolic reactions involved in the production of several compounds …
Micafungin
Micafungin is an antifungal drug. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
Approved
Investigational
Matched Description: … the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. ... It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting …
Triheptanoin
Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly.[A214812,A214817] Complications in lc-FAOD patients...
Approved
Investigational
Matched Description: … Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long ... Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of …
Dyclonine
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.
Approved
Prednisolone acetate
Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond. Prednisolone acetate was granted FDA approval in 1955.
Approved
Vet approved
Naxitamab
Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neuroblastoma - it is widely expressed across and within...
Approved
Matched Description: … of its predecessor. ... [A224474] One stark disadvantage of this therapy is the requirement for concurrent use of granulocyte-macrophage ... high-risk relapsed/refractory neuroblastoma of the bone or bone marrow. …
Dopamine
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Approved
Matched Description: … One of the catecholamine neurotransmitters in the brain. ... A family of receptors (receptors, dopamine) mediate its action. ... Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating …
Albutrepenonacog alfa
Albutrepenonacog alfa (rIX-RFP) is a recombinant fusion protein that links a recombinant coagulation factor IX (rFIX) with a recombinant human albumin (rAlbumin). It was developed by CSL Behring Canada, Inc and approved by Health Canada on April 26, 2017. It was also approved by FDA and EMA in 2016. It...
Approved
Matched Description: … It is currently marketed in the forms of 250, 500, 1000 and 2000 IU/vial.[L2305] …
Glyburide
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Description: … [L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels …
Tipiracil
Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been...
Approved
Investigational
Matched Description: … It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. ... The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its ... [A31255] TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been previously …
Glofitamab
Glofitamab is a full-length bispecific monoclonal antibody with affinity for both CD20 and CD3 surface antigens found on B- and T-cells, respectively. It has a 2:1 configuration, with bivalency towards CD20 and monovalency towards CD3, and works by recruiting T-cells directly to the surface of cancerous B-cells.[L45698,A258488]
Glofitamab was approved...
Approved
Investigational
Matched Description: … In June 2023, the FDA approved the use of glofitamab for the treatment of patients with relapsed or refractory ... systemic therapy under accelerated approval based on response rate and durability of response. ... [L45698,A258488]
Glofitamab was approved by Health Canada in March 2023 for the treatment of certain …
Displaying drugs 451 - 475 of 8033 in total