Displaying drugs 6551 - 6575 of 8039 in total
ENTR-601-44
ENTR-601-44 is an exon 44 skipping phosphorodiamidate morpholino oligonucleotide (PMO). Developed by Entrada Therapeutics, it was investigated for the treatment of Duchenne muscular dystrophy.
Investigational
Matched Description: … Developed by Entrada Therapeutics, it was investigated for the treatment of Duchenne muscular dystrophy …
IMMU-114
IMMU-114 is antibody-drug conjugate consisting of humanized anti-HLA-DR IgG4 monoclonal antibody specific for alpha-chain linked to SN-38 via a CL2A linker.
Investigational
Matched Description: … IMMU-114 is antibody-drug conjugate consisting of humanized anti-HLA-DR IgG4 monoclonal antibody specific …
DDP-225
DDP225 is both a noradrenaline reuptake inhibitor and a serotonin type 3 receptor (5-HT3) antagonist. Noradrenaline and serotonin are neurotransmitters that are known to be involved in the control of the gastrointestinal system. The unique combination of noradrenaline reuptake inhibition and 5-HT3 antagonism in one orally delivered compound represents a...
Investigational
Matched Description: … Noradrenaline and serotonin are neurotransmitters that are known to be involved in the control of the ... The unique combination of noradrenaline reuptake inhibition and 5-HT3 antagonism in one orally delivered …
CTS-21166
CTS-21166 is a small-molecule beta-secretase inhibitor, which is being developed as a disease-modifying treatment for Alzheimer's disease. CTS-21166 is the only BACE1 inhibitor that has passed Phase I clinical trial thus far. In 2008, CoMentis revealed this small compound as a transition-state analog inhibitor (structure is currently undisclosed) with excellent...
Investigational
Matched Description: … these have met the requirements of an ideal oral drug candidate. ... excellent properties in brain penetration, selectivity, metabolic stability, and oral availability; all of …
Loprazolam
Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence...
Experimental
Matched Description: … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. ... It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or …
Diminazene
Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a solid. This compound belongs to the phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent...
Experimental
Matched Description: … Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a solid. ... These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached ... Known drug targets of diminazene include HTH-type transcriptional regulator QacR, trypsin-1, amiloride-sensitive …
Siagoside
Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a role in cell growth, development, and repair. Siagoside completed phase 2 trials for parkinson's disease (PD) treatment. Sygen appears to...
Investigational
Matched Description: … by permanent unilateral ligation of the common carotid artery. ... Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. ... Treatment results in a 52% decrease in mortality 48 hours after the induction of ischemia in gerbils …
Distigmine
Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to DB00545 and DB01400. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase inhibitor that binds directly and competitively to the agonist binding sites of muscurinic receptors. Distigmine is available in several countries...
Experimental
Matched Description: … Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation ... carbamate cholinesterase inhibitor that binds directly and competitively to the agonist binding sites of ... Distigmine is available in several countries as a treatment of underactive detrusor and voiding dysfunction …
OSI-930
OSI-930 is an orally active inhibitor of two clinically validated targets: c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2). OSI-930 is designed to target both cancer cell proliferation and blood vessel growth (angiogenesis) in selected tumors. In preclinical studies, OSI-930 shows broad efficacy in tumor models representative of small...
Investigational
Matched Description: … OSI-930 is an orally active inhibitor of two clinically validated targets: c-Kit and the vascular endothelial ... In preclinical studies, OSI-930 shows broad efficacy in tumor models representative of small cell lung …
SVV-001
SVV-001 is investigated for use/treatment in cancer/tumors and lung cancer. SVV-001 is a solid. SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neuroendocrine features. SVV-001 has also demonstrated cancer-killing specificity 10,000 times higher than that...
Investigational
Matched Description: … novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of ... SVV-001 has also demonstrated cancer-killing specificity 10,000 times higher than that of traditional …
Amperozide
Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia in humans even though the drug was ultimately never clinically adopted for this indication....
Experimental
Matched Description: … It inhibits dopamine release and alters the firing of dopaminergic neurons. ... Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia …
ZYCOV-D
The ZYCOV-D vaccine candidate was developed by Cadila Healthcare Ltd. based in India . The vaccine was developed using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of interest . Once the plasmid DNA is introduced into host cells and the viral protein is translated,...
Investigational
Matched Description: … As of August, 2020 the candidate is in Phase II clinical trials[A219758]. ... using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of ... is translated, it elicits a strong immune response, stimulating the humoral and cellular components of …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. ... The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis ... BCG Prague as it has a better safety profile than some other BCG versions due to the lack of the RD2 …
Olokizumab
Interleukin-6 (IL-6) is an important cytokine with roles in immune cell proliferation/differentiation, energy and bone metabolism, and the acute phase response of the innate immune system. IL-6 pathway dysregulation is associated with chronic inflammation and lymphoproliferation, including in autoimmune conditions such as rheumatoid arthritis, Castleman disease, and cytokine release syndrome....
Investigational
Matched Description: … immune cell proliferation/differentiation, energy and bone metabolism, and the acute phase response of …
(R)-Rolipram
The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties.
Experimental
Matched Description: … The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties. …
Homocysteine
Homocysteine is a thiol-containing amino acid formed by a demethylation of methionine.
Experimental
Matched Description: … Homocysteine is a thiol-containing amino acid formed by a demethylation of methionine. …
NCX 701
Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol.
Investigational
Matched Description: … Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. …
99mTc-glucarate
99mTc-glucarate(GLA) is an agent for non-invasive detection of breast tumours.
Investigational
Matched Description: … 99mTc-glucarate(GLA) is an agent for non-invasive detection of breast tumours. …
Transcrocetinate
Vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma.
Investigational
Matched Description: … Vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. …
N-chlorotaurine
N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase.
Investigational
Matched Description: … N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase. …
Vixotrigine
Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
Investigational
Matched Description: … Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. …
Radafaxine
Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.
Investigational
Matched Description: … Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major. …
Alvelestat
Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease.
Investigational
Matched Description: … Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease. …
Avagacestat
Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease.
Investigational
Matched Description: … Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease. …
Displaying drugs 6551 - 6575 of 8039 in total