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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Iupac: … 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-5-cyano-3,4-dihydroxyoxolan ... -2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate …
Matched Description: … [L18438] Remdesivir was also approved by the European Commission on July 3, 2020. ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease ... Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase (RdRp) enzyme complex for …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 2-Ring ... SARS-CoV-2 Nucleotide Analog RNA Polymerase Inhibitor …
Matched Products: … VEKLURY 100 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADET …
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Synonyms: … p-N,N-bis(2-chloroethyl)amino-L-phenylalanine ... 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine ... 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine …
Matched Iupac: … (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid …
Matched Description: … Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. …
Matched Salts cas: … 3223-07-2
Matched Products: … İÇEREN FLAKON+1 ADET ÇÖZÜCÜ İÇEREN FLAKON ... อัลเคอแรน (เม็ด 2 มก.) ... ALKERAN® 2 MG TABLETAS …
Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly...
Approved
Matched Iupac: … 2-phenyl-1H-1,3-benzodiazole-6-sulfonic acid …
Matched Description: … Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that ... or UV-B exposure [A27151]. ... absorbs strongly at UV-B wavelengths. …
Matched Mixtures name: … Lift Anti-wrinkle Firming Day Cream SPF 16 ... Shiseido Urban Environment Tinted Uv Protector 3 ... g and h Protect Body …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … Covergirl Outlast All Day Stay Fabulous 3-IN-1 Foundation ... Sungirl SPF 3
Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Iupac: … (2R,3R,4S,5R)-4,5,6-tris[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2-{[3,4-dihydroxy-5- ... (3,4,5-trihydroxybenzoyloxy)benzoyloxy]methyl}oxan-3-yl 3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoate …
Matched Description: … It acts as a weak acid. ... Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-[(4-acetylbenzene)sulfonyl]-3-cyclohexylurea 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide ... 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea ... N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea …
Matched Iupac: … 1-(4-acetylbenzenesulfonyl)-3-cyclohexylurea …
Matched Description: … A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. …
Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Synonyms: … (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate …
Matched Iupac: … 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate …
Matched Description: … [L6295] Methocarbamol was FDA approved on 16 July 1957.[L6265] ... [A178441,A178450] It is a guaiacol glyceryl ether. ... Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated …
Matched Mixtures name: … Robaxisal C 1/2 ... Methoxisal-C 1/2 ... SINAXAR ® A TABLETAS …
Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet...
Approved
Matched Iupac: … 2,7-dihydroxy-2H-benzo[d]1,3-dioxa-2-bismacyclopentane-5-carboxylic acid …
Matched Description: … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. ... Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration …
Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Iupac: … 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea …
Matched Description: … fibroblast growth factor receptor 2 (FGFR2) fusion or another rearrangement as detected by an FDA-approved ... Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. ... [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR …
Matched Salts cas: … 1310746-12-3 ... 1310746-10-1
Matched Categories: … MATE 2 Inhibitors ... MATE 1 Inhibitors ... Fibroblast Growth Factor 2, antagonists & inhibitors ... Heterocyclic Compounds, 1-Ring ... Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors …
Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives developed by FoldRX. Tafamidis is structurally similar to diflusinal. Tafamidis was granted an EMA market authorisation on 16 November 2011 and FDA approval on 3 May 2019.
Approved
Investigational
Matched Iupac: … 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid …
Matched Description: … [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval ... on 3 May 2019. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Description: … Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow ... It is not a structural analog of the nitrogen mustards. ... According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … MYRAN TABLETS 2 mg ... MYLERAN TABLETAS 2 MG ... Myleran 2 mg Filmtabletten …
Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity and unstable...
Approved
Investigational
Matched Description: … Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation ... Emicizumab was originated as an improved form of hBS23 and it was approved on November 16, 2017. …
Matched Products: … HEMLİBRA 150 MG/ 1 ML S.C. ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... HEMLİBRA 30 MG/ 1 ML S.C. ENJEKSİYONLUK ÇÖZELTİ , 1 ADET ... ENJEKSİYONLUK ÇÖZELTİ, 1 ADET …
Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Synonyms: … Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs …
Matched Description: … a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), which is responsible ... [A262076] Patients with cTTP have a severe deficiency of a plasma metalloproteinase called ADAMTS13 ( ... Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia …
Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Synonyms: … {[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Iupac: … 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Description: … Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia ... In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under ... Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor …
Matched Categories: … Urate Transporter 1 Inhibitor ... Heterocyclic Compounds, 1-Ring ... Urate Transporter 1 Inhibitors …
Metrizoic acid is a molecule used as a contrast medium. It present a higher risk of allergic reactions due to its high osmolality. Its approval has been discontinued by the FDA. One study in 1976 demonstrated that metrizoic acid, when used for cardiac angiography, was well tolerated. A total of...
Approved
Matched Iupac: … 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid …
Matched Description: … Metrizoic acid is a molecule used as a contrast medium. ... over a three-year period. ... It present a higher risk of allergic reactions due to its high osmolality. …
Matched Salts cas: … 20828-80-2
Matched Categories: … Compounds used in a research, industrial, or household setting …
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Matched Synonyms: … N-(2,6-dichloro-3-methylphenyl)anthranilic acid ... N-(3-methyl-2,6-dichlorophenyl)anthranilic acid ... N-(2,6-dichloro-m-tolyl)anthranilic acid …
Matched Iupac: … 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid …
Matched Description: … A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. …
Matched Categories: … Non COX-2 selective NSAIDS …
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Approved
Investigational
Matched Synonyms: … (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester) …
Matched Iupac: … [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14 ... -tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate …
Matched Description: … An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. …
Matched Categories: … Adrenergic alpha-1 Receptor Antagonists …
Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Approved
Illicit
Matched Iupac: … 5-(butan-2-yl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione …
Matched Description: … Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate ... Talbutal is a schedule III drug in the U.S. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA...
Approved
Investigational
Vet approved
Matched Synonyms: … 5-ethyl-5-(1-methylbutyl)barbituric acid ... 5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione ... 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione …
Matched Iupac: … 5-ethyl-5-(pentan-2-yl)-1,3-diazinane-2,4,6-trione …
Matched Description: … A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl...
Approved
Matched Synonyms: … 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one …
Matched Iupac: … 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one …
Matched Description: … group via a C-, S-,N-,O-, or Se- glycosidic bond. ... Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally ... These are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another …
Matched Salts cas: … 96997-92-1
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours....
Approved
Matched Synonyms: … (6S)-6-(propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol …
Matched Iupac: … (6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol …
Matched Description: … It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug ... Rotigotine has been authorized as a treatment for RLS since August 2008. ... Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease …
Matched Salts cas: … 125572-93-2
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … NEUPRO® 6 MG/24 H ... NEUPRO® 4 MG /24 H ... Rotigotin UCB 1 mg/24 Stunden transdermales Pflaster …
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that...
Approved
Investigational
Matched Synonyms: … 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine ... 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline …
Matched Iupac: … 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine …
Matched Description: … Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. ... Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain …
Matched Mixtures name: … Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2% ... Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05% …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … QUIMARA-1
Flutemetamol (18F) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18. It is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.
Approved
Investigational
Matched Synonyms: … 2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol …
Matched Iupac: … 2-[3-(¹⁸F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol …
Matched Description: … Flutemetamol (18F) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring ... Compounds used in a research, industrial, or household setting …
Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.[A226300,L13203] Cortisone acetate...
Approved
Investigational
Matched Iupac: … ,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate ... 2-[(1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH …
Matched Description: … [A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory …
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant...
Approved
Investigational
Matched Iupac: … 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2- …
Matched Description: … Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment ... found to be resistant to treatment with imatinib (Gleevec), another tyrosine kinase inhibitor used as a ... A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Approved
Investigational
Matched Salts cas: … 527-07-1
Matched Mixtures name: … MULTIELECTROLITOS TIPO 1 ... Plasma-Lyte A ... PLASMA-LYTE A INJECTION …
Displaying drugs 726 - 750 of 13918 in total