Displaying drugs 726 - 750 of 8179 in total
Griseofulvin
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Approved
Investigational
Vet approved
Matched Description: … Griseofulvin may be given by mouth in the treatment of tinea infections. …
Novobiocin
Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964...
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Novobiocin sodium, a salt form of ... novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious ... infections due to susceptible strains of _Staphylococcus aureus_ when other less toxic antibiotics cannot …
Nilotinib
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant...
Approved
Investigational
Matched Description: … 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of …
Atezolizumab
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … inhibition of immune responses seen in some cancers. ... The rest of atezolizumab indications remain unaffected.[L44246] ... Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing …
Macimorelin
Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … Risk factors of AGHD include a history of childhood-onset GH deficiency or with hypothalamic/pituitary ... Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of ... specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of …
Phloxine B
Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing tablets. These tablets allow patients to visualise areas where more brushing and...
Approved
Sotrovimab
Sotrovimab (VIR-7831), also known as GSK4182136, is a monoclonal antibody that can neutralize the SARS-CoV-2 virus. Sotrovimab was initially been granted emergency use authorization (EUA) to treat mild-to-moderate COVID-19 on May 26, 2021, based on interim results from a clinical trial, where sotrovimab was found to reduce the risk of...
Approved
Investigational
Matched Description: … 2021, based on interim results from a clinical trial, where sotrovimab was found to reduce the risk of …
Histrelin
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Description: … This drug is a synthetic analog of naturally occurring GnRH with a higher potency. ... (CPP) due to their capacity to reduce LH levels and the concentration of sex steroids. ... Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin …
Finafloxacin
Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Description: … Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's …
Valoctocogene roxaparvovec
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … and measurable steady-state levels of coagulation factor VIII. ... to produce factor VIII protein and increase the levels of active factor VIII in blood. ... ] improve the clinical outcomes of patients but do not eliminate breakthrough bleeding. …
Melphalan flufenamide
Melphalan flufenamide, also known as melflufen or J1, is a prodrug of melphalan.[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. In vitro models show that melphalan is 10 to hundreds of times more potent than melphalan. The increased...
Approved
Withdrawn
Matched Description: … Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan]. ... [A230123] _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphalan ... option for patients with relapsed or refractory multiple myeloma who have attempted at least 4 lines of …
Adalimumab
Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid ... [L49101] A biosimilar marketed as Hyrimoz, a high-concentration formulation of adalimumab, is also available …
Heparin
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … bleeding and higher risk of osteoporosis in long term use. ... Furthermore, the effects of UH can typically be reversed by using protamine sulfate. ... Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers …
Sulconazole
Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.[L44592,L44597] Sulconazole appears to be effective...
Approved
Matched Description: … Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common ... [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial …
Cilgavimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … [A243351, A243356, L39411] As the RBD binding site of cilgavimab does not overlap with that of [tixagevimab ... reduce viral load and improve clinical symptoms of infection. ... The FDA and Health Canada advise healthcare providers to inform patients of this risk. …
Tixagevimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … [A243351, A243356, L39411] As the RBD binding site of tixagevimab does not overlap with that of [cilgavimab ... reduce viral load and improve clinical symptoms of infection. ... The FDA and Health Canada advise healthcare providers to inform patients of this risk. …
Niclosamide
Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms....
Approved
Investigational
Vet approved
Matched Description: … range of diseases. ... Niclosamide is an antihelminthic used for the treatment of tapeworm infections. ... Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad …
Cinnamyl alcohol
Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as DB14184 within commercial products.
Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% . Sensitivity...
Approved
Experimental
Matched Description: … Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% [A34266 …
Cetrorelix
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Description: … Cetrorelix does not allow the premature release of these eggs to occur. ... Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). …
Phylloquinone
Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II,...
Approved
Investigational
Matched Description: … of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity of vitamin ... [L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates ... [A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation …
Bepridil
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing...
Approved
Withdrawn
Sodium aurothiomalate
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Description: … of extensive deformities or in the treatment of other forms of arthritis. ... Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold ... It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence …
Susoctocog alfa
Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Description: … sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of ... These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this ... activated partial thromboplastin time (aPTT) assay, a conventional in vitro test for biological activity of …
Vaborbactam
Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for...
Approved
Investigational
Matched Description: … varying degrees of renal insufficiency. ... Vabomere consists of vaborbactam and [Meropenem] for intravenous administration. ... [A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with …
Displaying drugs 726 - 750 of 8179 in total