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Displaying drugs 851 - 875 of 895 in total
Ciglitazone
Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.
Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which—such as pioglitazone and troglitazone—made it to the market....
Experimental
Matched Categories: … Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) …
Aprobarbital
Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment indicated for the use of aprobarbital was subsequently insomnia. Aprobarbital was never as widely used as more common barbiturate derivatives...
Experimental
Illicit
Matched Categories: … Cytochrome P-450 CYP3A4 Inducers (strength unknown) …
Oleandomycin
Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus.
Vet approved
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Sagopilone
Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is the first such compound to be in clinical development to combat several forms of cancer. Epothilones are 16-member ring macrolides...
Investigational
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Rivoglitazone
Rivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
Experimental
Investigational
Matched Categories: … Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) …
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As...
Illicit
Matched Categories: … Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) …
Coltuximab ravtansine
Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic leukemia (ALL).
Investigational
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Bryostatin 1
Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
Investigational
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Interferon alfa
Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. Interferon alpha proteins are mainly involved in innate immune response against viral infection. They come in 13...
Investigational
Matched Categories: … Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) …
Netoglitazone
Netoglitazone (MCC-555) is a hypoglycemic agent.
Experimental
Matched Categories: … Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) …
Sparteine
Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker, so it falls in the category of class 1a antiarrhythmic agents. Sparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one...
Experimental
Withdrawn
Matched Categories: … Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) …
Nemonoxacin
Investigational
Matched Categories: … Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) …
Tienilic acid
Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)
Withdrawn
Matched Categories: … Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) …
Tofisopam
Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor and its psychopharmacological profile differs from such compounds. Although Tofisopam is not approved...
Experimental
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Piperine
Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.
Investigational
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Midecamycin
Midecamycin is a naturally occurring 16-membered macrolide that fits under the category of acetoxy-substituted macrolide antibiotics. In this molecule, an acetoxy group is substituted on the position 9 of the 16-member ring and on position 4 of the terminal sugar. Until 2017, midecamycin was still under the list of approved...
Experimental
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Sulfamoxole
Sulfamoxole is an antibacterial in the sulfonamide class.
Experimental
Matched Categories: … Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) …
Solithromycin
Solithromycin is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections.
Investigational
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Balaglitazone
Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
Investigational
Matched Categories: … Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) …
Artemisinin
Artemisinin has been used in trials studying the treatment of Schizophrenia, Malaria, Falciparum, and Plasmodium Falciparum.
Investigational
Matched Categories: … Cytochrome P-450 CYP2B6 Inducers (strength unknown) …
Rufloxacin
Rufloxacin is a quinolone antibiotic.
Experimental
Matched Categories: … Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) …
Doramectin
Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.
Vet approved
Matched Categories: … Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Insulin peglispro
Investigational
Matched Categories: … Cytochrome P-450 CYP1A2 Inducers (strength unknown) …
Sitafloxacin
Experimental
Investigational
Matched Categories: … Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) …
Allylestrenol
A synthetic steroid with progestational activity. It is widely marketed throughout Europe, including Russia and many other European countries, and is also available in Japan, Hong Kong, India, Bangladesh, Indonesia, and much of Southeast Asia, though notably not in the United States or Canada.
Experimental
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates (strength unknown) …
Displaying drugs 851 - 875 of 895 in total