Displaying drugs 976 - 1000 of 15100 in total
Aripiprazole lauroxil
Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors .
Affecting about 1% of the...
Approved
Investigational
Matched Description: … It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and ... catanoia, and negative symptoms that include social withdrawal, anhedonia, and flattening of emotional ... patients are faced with social stigma and discriminations. …
Matched Categories: … Aripiprazole and prodrugs …
Matched Categories: … Aripiprazole and prodrugs …
Procainamide
A derivative of procaine with less CNS action.
Approved
Matched Categories: … Benzamides and benzamide derivatives …
Copanlisib
Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational
Matched Description: … , that exists in different isoforms and is often overexpressed in hematological malignancies. ... pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and ... PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Sevelamer
Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Approved
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Crisaborole
Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis.
This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reducing the signs and symptoms in patients 2 years old and...
Approved
Investigational
Matched Description: … reducing the signs and symptoms in patients 2 years old and older. ... It reduces the local inflammation in the skin and prevents further exacerbation of the disease with a ... This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and …
Doripenem
Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that...
Approved
Investigational
Matched Description: … to reiterate its safety and efficacy for its approved indications. ... Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal ... In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin …
Human papillomavirus type 11 L1 capsid protein antigen
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Matched Description: … by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Tetradecyl hydrogen sulfate (ester)
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins .
Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose ... sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and ... Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report …
Tyrothricin
Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus . This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1,...
Approved
Matched Description: … Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus ... Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and ... other more minor contributors) and 40% neutral linear gramicidins (where valine-gramicidin A is often …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Beractant
Beractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as SP-B and SP-C. The...
Approved
Matched Description: … surfactant-associated proteins such as SP-B and SP-C. ... It is suspended in 0.9% sodium chloride solution, and heat-sterilized. ... from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and …
Pomalidomide
Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Approved
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Triflupromazine
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Approved
Vet approved
Matched Description: … A phenothiazine used as an antipsychotic agent and as an antiemetic. …
Nortriptyline
Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Description: … and other conditions. ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Carprofen
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild,...
Approved
Vet approved
Withdrawn
Matched Description: … nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. ... generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and …
Chlorambucil
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Approved
Matched Description: … nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Propiolactone
Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Description: … It has been used against bacteria, fungi, and virus. ... disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and …
Phloxine B
Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing tablets. These tablets allow patients to visualise areas where more brushing and...
Approved
Matched Description: … These tablets allow patients to visualise areas where more brushing and flossing are needed. …
Matched Categories: … Indicators and Reagents …
Matched Categories: … Indicators and Reagents …
Avapritinib
Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers. Avapritinib shares a...
Approved
Investigational
Matched Description: … Avapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived ... receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and ... Avapritinib was granted FDA approval on 9 January 2020 [L40363] and EMA approval on 24 September 2020 …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Golodirsen
Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … [L10773]
Golodirsen was developed by Sarepta Therapeutics and granted accelerated FDA approval on ... Often, patients succumb to this condition by age 30 or younger due to cardiac and respiratory complications …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Fosaprepitant
Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Approved
Matched Description: … It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment …
Matched Categories: … Aprepitant and Prodrugs …
Matched Categories: … Aprepitant and Prodrugs …
Gadolinium
Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
Approved
Investigational
Matched Description: … Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. ... Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery …
Chloroprocaine
Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of...
Approved
Investigational
Matched Description: … [A252952] Chloroprocaine can be given as an injection, and is available in formulations with and without ... formulation can be used for lumbar and caudal epidural blocks. ... [L43402] The pharmacological profile of chloroprocaine is characterized by a short latency and duration …
Galcanezumab
Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … promising safety and tolerability. ... treatment of migraine and the treatment of episodic cluster headache. ... Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Grepafloxacin
Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Approved
Investigational
Withdrawn
Matched Description: … QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and …
Displaying drugs 976 - 1000 of 15100 in total