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Displaying drugs 126 - 150 of 11696 in total
Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as ritonavir for the effective management of HIV-1 infection. As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV therapy.[A2278,A2281] It was initially approved by the FDA in 2006. Darunavir is being...
Approved
Matched Synonyms: … N-((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6 ... -dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide ... (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido …
Matched Iupac: … ]-1-phenylbutan-2-yl]carbamate ... (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido …
Matched Description: … [L9227] Darunavir is being studied as a possible treatment for SARS-CoV-2, the coronavirus responsible …
Matched Products: … PREZISTA 400 MG FILM KAPLI TABLET, 60 ADET ... PREZISTA 600 MG FILM KAPLI TABLET, 60 ADET …
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Synonyms: … 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone …
Matched Iupac: … 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one …
Matched Salts cas: … 41621-49-2
Matched Mixtures name: … Ciclopirox 0.77% / Salicylic Acid 2% ... Ciclopirox Olamine 1% / Salicylic Acid 2% …
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear,...
Approved
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … PAPAVERİN HCL 60 MG/ 2 ML ENJEKSİYONLUK ÇÖZELTİ, 10 AMPUL ... PAPAVERINE HCL 60 MG TABLET, 20 ADET ... PAPAVERIN HCL BIOFARMA 60 MG / 2ML AMPUL, 10 ADET …
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Synonyms: … 2-Hydroxyethyl cellulose ether …
Matched Iupac: … 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3- ... yl]oxy}oxan-2-yl]methoxy}propan-2-ol …
Matched Salts name: … Hydroxyethyl cellulose (100 MPa.s at 2%) ... Hydroxyethyl cellulose (1800 MPa.s at 2%) ... Hydroxyethyl cellulose (280 MPa.s at 2%) ... Hydroxyethyl cellulose (40 MPa.s at 2%) ... Hydroxyethyl cellulose (5500 MPa.s at 2%) …
An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed,...
Approved
Matched Synonyms: … 2-Amino-2-(hydroxymethyl)-1,3-propanediol …
Matched Iupac: … 2-amino-2-(hydroxymethyl)propane-1,3-diol …
Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
Approved
Withdrawn
Matched Synonyms: … 1-Methyl-4-N-2-thenylanilinopiperidine ... 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine …
Matched Iupac: … 1-methyl-N-phenyl-N-[(thiophen-2-yl)methyl]piperidin-4-amine …
Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 in several European countries before being withdrawn two years later because of...
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one …
Matched Iupac: … 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Dexibuprofen has a...
Approved
Investigational
Matched Synonyms: … (2S)-2-(4-isobutylphenyl)propanoic acid ... (S)-α-methyl-4-(2-methylpropyl)benzeneacetic acid …
Matched Iupac: … (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Approved
Experimental
Matched Synonyms: … (S)-2-hydroxypropanoic acid ... (S)-2-hydroxypropionic acid …
Matched Iupac: … (2S)-2-hydroxypropanoic acid …
Matched Mixtures name: … Prismasol 2
Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation,...
Approved
Investigational
Matched Synonyms: … ]carbonyl]-2-thiazolyl]ethyl]- ... 6-Amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl ... 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino …
Matched Iupac: … 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl) …
Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Matched Synonyms: … ]oct-2-ene-2-carboxylic acid ... (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0 …
Matched Iupac: … ]oct-2-ene-2-carboxylic acid ... (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Synonyms: … 16,16-Dimethyl-trans-delta-2-PGE1 methyl ester ... 16,16-Dimethyl-trans-delta(sup 2)-prostaglandin E1 methyl ester …
Matched Iupac: … hept-2-enoate ... methyl (2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4,4-dimethyloct-1-en-1-yl]-5-oxocyclopentyl] …
Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked...
Approved
Investigational
Matched Synonyms: … glycyl-L-2-methylprolyl-L-glutamic acid …
Matched Iupac: … (2S)-2-{[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl]formamido}pentanedioic acid …
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the...
Approved
Investigational
Matched Synonyms: … 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid ... 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid …
Matched Iupac: … 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Products: … BUSULSEVEN 60 ... INJECTION 60 mg/vial ... MYRAN TABLETS 2 mg …
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.
Approved
Investigational
Matched Synonyms: … (2R)-2-acetylamino-3-sulfanylpropanoic acid ... (R)-2-acetylamino-3-mercaptopropanoic acid …
Matched Iupac: … (2R)-2-acetamido-3-sulfanylpropanoic acid …
Matched Mixtures name: … Protect Plus SO 60
Matched Products: … FLUIMUCIL® 2% ... HYSTIN SOLUCIONORAL 2 % ... N-ACETILCISTEÍNA 2 G / 100 ML JARABE …
Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996....
Approved
Vet approved
Matched Synonyms: … 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane …
Matched Iupac: … 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane …
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Approved
Investigational
Nutraceutical
Matched Synonyms: … 2-Aminosuccinamic acid ... L-2-aminosuccinamic acid ... (2S)-2-amino-3-carbamoylpropanoic acid …
Matched Iupac: … (2S)-2-amino-3-carbamoylpropanoic acid …
Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Synonyms: … 2-(Trimethylammonio)Acetate ... 2-trimethylammonioacetate ... 2-N,N,N-trimethylammonio acetate …
Matched Iupac: … 2-(trimethylazaniumyl)acetate …
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell...
Approved
Investigational
Vet approved
Matched Synonyms: … (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine ... (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine …
Matched Iupac: … [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine …
Matched Mixtures name: … Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4% …
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Iupac: … 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)- …
Matched Description: … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes ... glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2
Matched Mixtures name: … GLUCOVEL 2 ... LAPIGIM 2/500 ... VELACOM PLUS 2/500 …
Matched Products: … GLIMAX 2 MG TABLET, 60 ADET ... SANPRID 2 MG TABLET, 60 ADET ... MEPIRIKS 2 MG TABLET, 60 ADET …
Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections. Clavulanic acid is derived from the organism Streptomyces clavuligerus. When it is combined with amoxicillin, clavulanic acid is...
Approved
Vet approved
Matched Synonyms: … (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid …
Matched Iupac: … (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Mixtures name: … KLAMOKS 312.5 MG FORT ORAL SÜSPANSİYON HAZIRLAMAK İÇİN KURU TOZ, 60 ML ... KLAMOKS 156.25 MG PEDİATRİK ORAL SÜSPANSİYON HAZIRLAMAK İÇİN KURU TOZ, 60 ML …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Synonyms: … ]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid ... (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl …
Matched Iupac: … 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists …
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and picosulfate are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Approved
Matched Synonyms: … Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) …
Matched Iupac: … 4-{[4-(acetyloxy)phenyl](pyridin-2-yl)methyl}phenyl acetate …
Matched Description: … bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2- …
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Synonyms: … -2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate ... 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone ... (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran …
Matched Iupac: … -1-yl (2S)-2-methylbutanoate ... (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen …
Matched Description: … cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2
Displaying drugs 126 - 150 of 11696 in total