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Displaying drugs 126 - 150 of 9611 in total

Sargramostim

Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Approved
Investigational
Matched Description: … Substitution of Leu23 leads to a difference from native protein. …

Flunitrazepam

Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
Approved
Illicit
Matched Description: … The United States Government has banned the importation of this drug. ... Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause …

Trypsin

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine....
Approved
Vet approved
Matched Description: … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is ... an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of ... This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate- …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Perflubutane

Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.
Approved
Investigational
Matched Description: … Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis …
Matched Categories: … Diagnostic Uses of Chemicals …

Troglitazone

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Description: … Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. …

Crotamiton

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Approved
Matched Products: … CROPITON(R) …

Fluorometholone

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Approved
Investigational
Matched Description: … of the eye. ... It has also been used topically in the treatment of various skin disorders. ... A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … F M L(R) …

Gadobutrol

Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to other GBCA and thus requires a lesser...
Approved
Matched Description: … of NSF thanks to the macrocyclic structures that limit dechelation of gadolinium. ... contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of ... [A7001] Like other GBCA, gadobutrol usage carries the risk of nephrogenic systemic fibrosis (NSF) …
Matched Categories: … Diagnostic Uses of Chemicals …

Strontium ranelate

Strontium ranelate, a strontium (II) salt of ranelic acid, is a medication for osteoporosis. Some reports have shown that strontium ranelate can slow down the progression of osteoarthritis of the knee. This agent presents an atypical mechanism of action in which it increases deposition of new bone by osteoblasts and,...
Approved
Withdrawn
Matched Description: … Some reports have shown that strontium ranelate can slow down the progression of osteoarthritis of the ... intrinsic bone tissue quality and microarchitecture in osteoporosis by way of a number of cellular and ... This agent presents an atypical mechanism of action in which it increases deposition of new bone by osteoblasts …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Technetium Tc-99m pertechnetate

Technetium Tc-99m pertechnetate is a radiopharmaceutical diagnostic agent composed of an oxoanion with the chemical formula TcO4-. Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. It also concentrates in the thyroid gland, salivary glands, gastric mucosa,...
Approved
Investigational
Matched Description: … Technetium Tc-99m pertechnetate is a radiopharmaceutical diagnostic agent composed of an oxoanion with ... Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to ... Currently marketed as the product Drytec, technetium-99m pertechnetate is indicated for imaging of the …
Matched Categories: … Diagnostic Uses of Chemicals …

Pantothenic acid

Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats....
Approved
Nutraceutical
Vet approved
Matched Description: … (L) form may antagonize the effects of the dextrorotatory isomer. ... Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain ... Only the dextrorotatory (D) isomer of pantothenic acid possesses biological activity. while the levorotatory …
Matched Mixtures name: … Harvest Of Values All B Complex Tab ... Herbs of Gold B Complex Plus Softgel …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Methadone

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a...
Approved
Matched Description: … , and a long duration of action. ... Provision of OAT is often combined with education about harm reduction including use of clean needles ... The intention of substitution of illicit opioids with the long-acting opioids used in OAT is to prevent …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Cetuximab

Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. ... [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour ... competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of …

Lasofoxifene

Lasofoxifene is a non-steroidal 3rd generation selective estrogen receptor modulator (SERM) that selectively binds to both ERα and ERβ with high affinity. It is a naphthalene derivative marketed for prevention and treatment of osteoporosis and for the treatment of vaginal atrophy. It was initially developed as Oporia by Pfizer as...
Approved
Investigational
Matched Description: … of vaginal atrophy. ... It is a naphthalene derivative marketed for prevention and treatment of osteoporosis and for the treatment ... signed a license agreement with Sermonix Pharmaceuticals for the development and commercialization of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Technetium Tc-99m tetrofosmin

Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Description: … 99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of …
Matched Categories: … Diagnostic Uses of Chemicals …

Torasemide

Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993.
Approved
Matched Categories: … combinations of sulfonamides ... Increased Diuresis at Loop of Henle …

Tapentadol

Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011....
Approved
Matched Description: … Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. ... The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011. ... [L47291] Used in the management of pain, tapentadol is typically reserved for patients who have limited …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tetracaine

Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Approved
Vet approved
Matched Mixtures name: … Dermacaine-R …
Matched Categories: … Esters of Aminobenzoic Acid ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Curcuma aromatica root oil

Curcuma aromatica root oil is obtained from the roots of Curcuma aromatica, or more commonly called wild tumeric, via steamed distillation. Curcuma aromatica belongs to the family Zingiberaceae. The wild ginger has been used as a cosmetic herbal where its rhizomes exhibit a distinct fragrance and color. The major constituents...
Approved
Matched Description: … Curcuma aromatica root oil is obtained from the roots of *Curcuma aromatica*, or more commonly called ... The major constituents of Curcuma aromatica root oil are reported to be camphor, curzerenone, α-turmerone …

Cyclacillin

A cyclohexylamido analog of penicillanic acid.
Approved
Matched Description: … A cyclohexylamido analog of penicillanic acid. …
Matched Categories: … combinations of penicillins …

Meglumine

Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Gadoversetamide

Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Approved
Investigational
Matched Description: … gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of …
Matched Categories: … Diagnostic Uses of Chemicals …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … X-linked hypophosphatemia causes low circulating levels of phosphorus in the blood. ... children ages 1 year and older with X-linked hypophosphatemia (XLH), which is a rare, inherited form of …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Pamidronic acid

Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to neridronic acid and alendronic acid. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid are becoming...
Approved
Matched Categories: … Drugs for Treatment of Bone Diseases …

Secnidazole

Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Description: … A245508] In September 2017, FDA approved secnidazole under the market name Solosec for the treatment of …
Matched Products: … GIAFAR(R) 1 G TABLETAS ... DAKSOL(R)1 G TABLETAS …
Displaying drugs 126 - 150 of 9611 in total