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Displaying drugs 151 - 175 of 14852 in total

Saxagliptin

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Approved
Matched Mixtures name: … Saxagliptin and Metformin Hydrochloride ... Saxagliptin and Metformin Hydrochloride ... Saxagliptin and Metformin Hydrochloride …
Matched Salts name: … Saxagliptin hydrochloride ... Saxagliptin hydrochloride dihydrate …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and saxagliptin ... Amino Acids, Peptides, and Proteins ... saxagliptin and dapagliflozin ... metformin, saxagliptin and dapagliflozin …

Leuprolide

Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to...
Approved
Investigational
Matched Description: … downstream modulation of both gonadotropin hormone and sex steroid levels. ... [A203222] As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing ... [L13850] Since this initial approval, various long-acting intramuscular and subcutaneous products have …
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... leuprorelin and bicalutamide ... Antineoplastic and Immunomodulating Agents …
Matched Products: … POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 45mg ... POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 7.5mg ... POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 22.5mg …

Tioconazole

Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In...
Approved
Matched Description: … Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. ... Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus …
Matched Salts name: … Tioconazole hydrochloride …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Up and up tioconazole 1 ... Foster and Thrive Tioconazole …

Nalbuphine

A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Approved
Matched Description: … It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid …
Matched Salts name: … Nalbuphine hydrochloride …
Matched Products: … Nalbuphine Hydrochloride …

Hexachlorophene

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Approved
Withdrawn
Matched Description: … It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders …
Matched Categories: … Phenol and Derivatives ... Antiseptics and Disinfectants …

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood...
Approved
Investigational
Matched Description: … Repaglinide is extensively metabolized in the liver and excreted in bile. ... insulin and appears to occur only in those naïve to oral antidiabetic agents. ... It should only be taken with meals and meal-time doses should be skipped with any skipped meal. …
Matched Mixtures name: … Repaglinide and Metformin Hydrochloride ... Repaglinide and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and repaglinide …

Paroxetine

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline...
Approved
Investigational
Matched Description: … of serotonin reuptake and has little effect on other neurotransmitters. ... [T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. ... uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and …
Matched Salts name: … Paroxetine hydrochloride ... Paroxetine hydrochloride hemihydrate …
Matched Products: … Paroxetine Hydrochloride ... Paroxetine Hydrochloride CR ... Paroxetine Hydrochloride Anhydrous …

Methylcellulose

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3,...
Approved
Matched Description: … emulsifier for foodstuffs and cosmetics. ... Like cellulose, it is not digestible, not toxic, and not allergenic ... Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Foster and Thrive Fiber Laxative 188 …

Lurasidone

Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently …
Matched Salts name: … Lurasidone hydrochloride …
Matched Products: … Lurasidone Hydrochloride ... Lurasidone hydrochloride …

Meclizine

Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects. Commonly marketed under the brand name Antivert in...
Approved
Matched Description: … Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. ... It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects. ... It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular …
Matched Salts name: … Meclizine hydrochloride …
Matched Products: … Meclizine Hydrochloride ... Meclizine hydrochloride …

Minoxidil

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Approved
Investigational
Matched Description: … potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and …
Matched Categories: … Skin and Mucous Membrane Agents …
Matched Products: … Up and Up Minoxidil ... Up and Up minoxidil ... Berkley and Jensen Minoxidil …

Trazodone

Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the...
Approved
Investigational
Matched Description: … Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors ... [A181180] It is used in adults and has been shown to be comparable in efficacy to other drugs such as ... promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and …
Matched Salts name: … Trazodone hydrochloride …
Matched Categories: … Serotonin antagonist and reuptake inhibitors (SARIs) …
Matched Products: … Trazodone Hydrochloride …

Levonordefrin

Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
Approved
Matched Description: … Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. …
Matched Mixtures name: … Mepivacaine Hydrochloride and Levonordefrin ... Mepivacaine Hydrochloride with Levonordefrin …
Matched Categories: … Epinephrine and similars …

Bisacodyl

Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and picosulfate are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Approved
Matched Description: … [A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-( …
Matched Mixtures name: … HalfLytely and Bisacodyl ... HalfLytely and Bisacodyl ... GaviLyte-H and Bisacodyl …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Up and Up womens laxative ... Up and Up Gentle Laxative ... Foster and Thrive Gentle Laxative …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … and proliferation. ... IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth ... [A248750] Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Glimepiride

First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … long-term microvascular and macrovascular complications that lead to co-morbidities and mortalities. ... worldwide; it is characterized by insulin resistance in accordance with progressive β cell failure and ... present,[A177715] as they work by stimulating the release of insulin from the pancreatic beta cells and …
Matched Mixtures name: … Pioglitazone hydrochloride and glimepiride ... Pioglitazone hydrochloride and glimepiride ... Pioglitazone and Glimepiride …
Matched Categories: … Alimentary Tract and Metabolism ... glimepiride and pioglitazone ... glimepiride and rosiglitazone …

Tetryzoline

Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties. Available since the 1950s, tetryzoline is a selective α1-receptor agonist that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most...
Approved
Matched Description: … such as [povidone], [polyethylene glycol 400], [dextran], and [zinc sulfate]. ... scrutinized for possible drug overdose and toxicity from accidental ingestion. ... Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral …
Matched Mixtures name: … Up and Up Ultra Itchy Relief ... Redness reliever and Lubricant ... Seasonal itchy and Red eye relief …
Matched Salts name: … Tetrahydrozoline hydrochloride …
Matched Categories: … Decongestants and Antiallergics …
Matched Products: … Foster and Thrive Original Formula Eye Drops ... Walgreens Eye Drops Original 15mL and twin pack …

Pepsin

Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products . Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated...
Approved
Experimental
Investigational
Matched Description: … Stimulation of the pancreas and therefore enzymatic digestion of food is a tightly controlled and is ... Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and ... Any changes or conditions affecting metabolic steps for successful digestion and absorption negatively …
Matched Mixtures name: … Glutamic Acid Hydrochloride Nu Life ... Betaine HCl and Pepsin ... Pancreatin and Enzyme Formula - Tablet …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... pepsin and acid preparations …

Acebutolol

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Approved
Investigational
Matched Description: … The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic …
Matched Salts name: … Acebutolol hydrochloride …
Matched Categories: … acebutolol and thiazides ... Beta Blocking Agents and Thiazides ... Beta Blocking Agents, Selective, and Thiazides …
Matched Products: … Acebutolol Hydrochloride …

Sevelamer

Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Approved
Matched Salts name: … Sevelamer hydrochloride …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Matched Products: … Sevelamer Hydrochloride ... Sevelamer hydrochloride …

Chlorphenesin

Approved
Experimental
Matched Mixtures name: … Alcohol Wet Tissue …

Flavoxate

A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
Approved
Matched Description: … Its therapeutic usefulness and its mechanism of action are not clear. ... A drug that has been used in various urinary syndromes and as an antispasmodic. ... It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity …
Matched Salts name: … Flavoxate hydrochloride …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Matched Products: … Flavoxate Hydrochloride …

Dexchlorpheniramine maleate

Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Approved
Matched Description: … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic …
Matched Mixtures name: … Chlophedianol Hydrochloride, Dexchlorpheniramine Maleate, and Pseudoephedrine Hydrochloride …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … HIF1α and HIF2α and the induces erythropoiesis. ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254157] On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... Hypoxia-Inducible Factor-Proline Dioxygenases, antagonists & inhibitors …

Cetalkonium

Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Cetalkonium is approved by the FDA for its use...
Approved
Matched Iupac: … benzyl(hexadecyl)dimethylazanium …
Matched Description: … [A27143] It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and …
Displaying drugs 151 - 175 of 14852 in total