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Displaying drugs 1876 - 1900 of 15886 in total

Tenofovir disoproxil

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Iupac: … bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate …
Matched Mixtures name: … Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate …
Matched Categories: … Tenofovir and prodrugs ... lamivudine and tenofovir disoproxil ... tenofovir disoproxil and emtricitabine ... lamivudine, tenofovir disoproxil and efavirenz ... lamivudine, tenofovir disoproxil and doravirine …

Ciprofibrate

Approved
Investigational
Matched Iupac: … 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid …

Lacidipine

Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia . It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce...
Approved
Investigational
Matched Description: … vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and ... displays a high membrane partition coefficient leading to accumulation of the drug in the membrane and ... other long-acting dihydropyridine calcium antagonists, thiazide diuretics, atenolol (a beta-blocker) and …
Matched Categories: … Calcium-Regulating Hormones and Agents …

Tromantadine

Tromantadine is marketed as Viru-Merz in the Czech Republic . It is an antiviral used in the treatment of herpes zoster and simplex.
Approved
Matched Description: … It is an antiviral used in the treatment of herpes zoster and simplex. …

Dacarbazine

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Serdexmethylphenidate

Attention Deficit Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity.[A230698, A230703] The underlying cause of ADHD is unclear but likely involves dysfunction in dopaminergic and noradrenergic neurotransmission, as evidenced by the clear...
Approved
Matched Iupac: … carboxylato-2-hydroxyethyl]carbamoyl}-1-{[(2R)-2-[(1R)-2-methoxy-2-oxo-1-phenylethyl]piperidine-1-carbonyloxy]methyl …
Matched Description: … is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity ... [amphetamine] that increase extracellular dopamine and norepinephrine levels. ... Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and …
Matched Categories: … dexmethylphenidate and serdexmethylphenidate ... Psychostimulants, Agents Used for ADHD and Nootropics …

Peginesatide

Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide...
Approved
Investigational
Matched Description: … iminodiacetic acid and β-alanine. ... The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life ... Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from …
Matched Categories: … Increased Erythroid Cell Production ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Autologous cultured chondrocytes

Autologous cultured chrondrocytes are used as autologous cell therapy to repair articular cartilage injuries in the knee (femoral condyle) due to acute or repetitive trauma. It serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods. The surgical implantation shows a tolerable safety profile and...
Approved
Investigational
Matched Description: … Autologous cultured chrondrocytes are used as autologous cell therapy to repair articular cartilage injuries ... It has been used since 1995 as Carticel and gained biologic license in 1997. ... The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not …
Matched Categories: … Autologous Cultured Cell …

Nicorandil

Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium...
Approved
Investigational
Matched Description: … It is shown to dilate normal and stenotic coronary arteries and reduces both ventricular preload and ... , most of Europe, India, Philippines, Japan, South Korea, and Taiwan. ... Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia …

Diosmin

Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or...
Approved
Investigational
Matched Iupac: … -7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl …
Matched Description: … circulation and symptoms of venous disease. ... Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving ... Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile …
Matched Mixtures name: … VENAFIX (Diosmin and Hesperidin Tablet) …

Foreskin fibroblast (neonatal)

Foreskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types . Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports wound healing . Dermagraft has only...
Approved
Matched Description: … stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell ... , as well as New Zealand and Australia. ... The impact of diabetic foot ulcers (DFU) on individuals and society is devastating. …
Matched Categories: … Allogeneic Cultured Cell Scaffold …

Bovine type I collagen

Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues. It plays a vital role in cell growth, differentiation, attachment, and migration . Often combined with other ingredients, such as fibroblasts and keratinocytes, it allows for accelerated and effective wound healing...
Approved
Matched Description: … It plays a vital role in cell growth, differentiation, attachment, and migration [L2481]. ... skin tears) and draining wounds [L2500]. ... and effective wound healing [L2427], [L2450]. …
Matched Categories: … Allogeneic Cultured Cell Scaffold …

Foreskin keratinocyte (neonatal)

Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … A gel made of bovine collagen is used as the matrix for cell growth and differentiation. ... Foreskin keratinocytes are a form of skin cells that are cultured as a skin cell replacement for wounds ... It is used for grafting onto partial-thickness wounds, where it offers a favorable matrix for host cell …
Matched Categories: … Allogeneic Cultured Cell Scaffold …

Tafenoquine

Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoquine was...
Approved
Investigational
Matched Iupac: … N4-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine …
Matched Description: … [A35690] Tafenoquine was further developed collaboratively between GlaxoSmithKline and Medicines for …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Quinestrol

The 3-cyclopentyl ether of ethinyl estradiol.
Approved
Matched Iupac: … (1R,3aS,3bR,9bS,11aS)-7-(cyclopentyloxy)-1-ethynyl-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Ephedrine

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons,...
Approved
Matched Description: … [A193698] Ephedrine acts as both a direct and indirect sympathomimetic. ... It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of ... [A193650,L12972] Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic …
Matched Categories: … Epinephrine and similars ... Herbs and Natural Products ... Mydriatics and Cycloplegics ... Adrenergic and Dopaminergic Agents ... Alimentary Tract and Metabolism …

Clioquinol

Clioquinol was withdrawn in 1983 due to neurotoxicity.
Approved
Vet approved
Withdrawn
Matched Categories: … Cell-mediated Immunity ... Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …

Belatacept

Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Investigational
Matched Description: … Belatacept selectively blocks the process of T-cell activation. ... domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and ... Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and …
Matched Categories: … Selective T Cell Costimulation Blocker ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Simoctocog alfa

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … replaced by a 16 amino acid linker. ... Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell ... lines led to decreased immunogenicity and longer half-life [A31525]. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Necitumumab

Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, metastasis, angiogenesis, and...
Approved
Investigational
Matched Description: … , a process that is involved in cell proliferation, metastasis, angiogenesis, and malignant progression ... for metastatic squamous non-small cell lung cancer (NSCLC). ... intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Chromium Cr-51

Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and in hematology to determine red blood cell volume or mass, study the red blood cell survival time...
Approved
Matched Description: … in hematology to determine red blood cell volume or mass, study the red blood cell survival time and ... diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and …

Pexidartinib

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial...
Approved
Investigational
Matched Iupac: … 5-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin …
Matched Description: … and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue. ... 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor ... [L7901] Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Potassium cation

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium...
Approved
Investigational
Matched Description: … The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a ... The balance between potassium and sodium is maintained by ion pumps in the cell membrane. ... differences of these charged particles causes a difference in electric potential between the inside and …

Telavancin

Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Iupac: … }.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid ... dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl ... -2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-36-{[(phosphonomethyl)amino]methyl}-7,13-dioxa-21,24,27,41,43 …
Matched Description: … skin and subcutaneous tissue infections among others. ... vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and ... pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Sulfacytine

Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism...
Approved
Matched Description: … in the folic acid metabolism cycle. ... High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. ... sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Displaying drugs 1876 - 1900 of 15886 in total