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Displaying drugs 176 - 200 of 12995 in total
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and picosulfate are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Approved
Matched Synonyms: … Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) …
Matched Iupac: … 4-{[4-(acetyloxy)phenyl](pyridin-2-yl)methyl}phenyl acetate …
Matched Description: … bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2- …
Matched Mixtures name: … BEKUNIS 3 MG/5 MG KAPLI TABLET, 30 ADET …
Matched Products: … ERPLUS(R) GRAGEAS ... BET-R-PREP Bisacodyl ... SUPOLAKS 5 MG SUPOZITUVAR,5 ADET …
Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it...
Approved
Investigational
Matched Synonyms: … 5-azacytidine ... 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one …
Matched Iupac: … 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one …
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell...
Approved
Investigational
Vet approved
Matched Synonyms: … (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine ... (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine …
Matched Iupac: … [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine …
Matched Salts cas: … 78628-80-5
Matched Mixtures name: … Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4% …
Matched Products: … Terbinafine HCl 5% …
Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera Chondrodendron and Strychnos....
Approved
Matched Synonyms: … 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium …
Matched Description: … [A216038] Tubocurarine's clinical use was limited by its relatively long duration of action (30-60 minutes …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab...
Approved
Matched Synonyms: … 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one ... 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one …
Matched Iupac: … 5-fluoro-3-phenyl-2-[(1S)-1-[(9H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one …
Matched Description: … cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5
Matched Categories: … Heterocyclic Compounds, 2-Ring …
A peptide that is a homopolymer of glutamic acid.
Approved
Nutraceutical
Matched Synonyms: … (2S)-2-Aminopentanedioic acid ... (S)-2-Aminopentanedioic acid …
Matched Iupac: … (2S)-2-aminopentanedioic acid …
Matched Mixtures name: … Aminosyn II 5% Inj ... AMINOPLASMAL-5% E INFUSION …
A systemic agricultural fungicide and seed treatment agent.
Approved
Experimental
Matched Synonyms: … 5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide ... 5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin ... 5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide …
Matched Iupac: … 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide …
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is...
Approved
Matched Synonyms: … (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol ... 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol ... (R)-noradrenaline …
Matched Iupac: … 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists ... Adrenergic beta-2 Receptor Agonists …
Matched Products: … Levophed(r) Norepinephrine Bitartrate ... Norepinephrine Bitartrate In 5% Dextrose Injection ... Mykronor 5 Mikrogramm/ml Injektions-/Infusionslösung …
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]...
Approved
Matched Synonyms: … 1-Methylimidazole-2(3H)-thione …
Matched Iupac: … 1-methyl-2,3-dihydro-1H-imidazole-2-thione …
Matched Products: … VELTHROM 5 ... THYROZOL 5 ... THYROZOL TABLET 5 mg …
A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Approved
Nutraceutical
Matched Synonyms: … (S)-2-amino-4-(methylthio)butanoic acid ... (S)-2-amino-4-(methylthio)butyric acid ... (2S)-2-amino-4-(methylsulfanyl)butanoic acid …
Matched Iupac: … (2S)-2-amino-4-(methylsulfanyl)butanoic acid …
Matched Mixtures name: … AMINOMIX 2 NOVUM 1000 ML ... AMINOMIX 2 NOVUM 1500 ML ... AMINOMIX 2 NOVUM 2000 ML …
A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Approved
Investigational
Matched Synonyms: … 5-imidazoleethylamine ... 2-(4-imidazolyl)ethylamine …
Matched Iupac: … 2-(1H-imidazol-4-yl)ethan-1-amine …
Matched Mixtures name: … Histamine DHCl 0.10 Percent and Menthol 2 Percent …
A derivative of procaine with less CNS action.
Approved
Matched Synonyms: … p-Amino-N-(2-diethylaminoethyl)benzamide …
Matched Iupac: … 4-amino-N-[2-(diethylamino)ethyl]benzamide …
Matched Categories: … MATE 2 Substrates ... MATE 2 Substrates with a Narrow Therapeutic Index …
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Approved
Withdrawn
Matched Synonyms: … 2,2'-dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane ... bis(2-hydroxy-3,5,6-trichlorophenyl)methane ... bis(3,5,6-trichloro-2-hydroxyphenyl)methane …
Matched Iupac: … 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol …
Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal...
Approved
Withdrawn
Matched Synonyms: … 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine ... 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline …
Matched Iupac: … 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists...
Approved
Investigational
Matched Synonyms: … (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide ... R-modafinil ... (R)-modafinil …
Matched Iupac: … 2-[(R)-diphenylmethanesulfinyl]acetamide …
Matched Description: … Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. …
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Synonyms: … [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine …
Matched Iupac: … N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Approved
Matched Synonyms: … Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl ester …
Matched Iupac: … 4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-2,3,6-trimethylphenyl acetate …
Matched Description: … A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. …
Matched Salts cas: … 36592-77-5
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins . Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Synonyms: … 7-Ethyl-2-methyl-4-undecanol sulfate …
Matched Iupac: … [(7-ethyl-2-methylundecan-4-yl)oxy]sulfonic acid …
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear,...
Approved
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … PAPAVERİN HCL 60 MG/ 2 ML ENJEKSİYONLUK ÇÖZELTİ, 10 AMPUL ... PAPAVERINE HCL 60 MG TABLET, 20 ADET ... PAPAVERIN HCL BIOFARMA 60 MG / 2ML AMPUL, 10 ADET …
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985)....
Approved
Investigational
Matched Synonyms: … N,N'-Bis(2-chloroethyl)-N-nitrosourea …
Matched Iupac: … 1,3-bis(2-chloroethyl)-1-nitrosourea …
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Iupac: … 3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)- …
Matched Description: … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes ... glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2
Matched Mixtures name: … GLUCOVEL 2 ... LAPIGIM 2/500 ... VELACOM PLUS 2/500 …
Matched Products: … GLIMEPIRIDE SANDOZ(R) (2 MG) ... GLIMAX 2 MG TABLET, 60 ADET ... SANPRID 2 MG TABLET, 60 ADET …
A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan...
Approved
Investigational
Matched Synonyms: … bis(2-chloroethyl)methylamine ... methylbis(2-chloroethyl)amine ... N-methyl-bis(2-chloroethyl)amine …
Matched Iupac: … bis(2-chloroethyl)(methyl)amine …
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Synonyms: … 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine …
Matched Iupac: … 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3(7),5,8,10,12 …
Matched Categories: … Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists ... Serotonin 5-HT2C Receptor Antagonists …
Matched Products: … ZAPIN(R) 10 MG TABLETA RECUBIERTA ... SOPAVEL 5 ODT ... โอลาพิน-5
A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Approved
Matched Synonyms: … 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one …
Matched Iupac: … 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10- …
Matched Products: … VIRAMUNE 200 MG TABLET, 60 ADET …
Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor B. Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase. This is...
Approved
Investigational
Matched Synonyms: … 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl) benzoic acid ... BENZOIC ACID, 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)-2-PIPERIDINYL)- …
Matched Iupac: … 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid …
Matched Description: … progeny erythrocytes will lack the glycosyl phosphatidylinositol–anchored proteins that normally anchor 2
Matched Salts cas: … 2447007-60-3 …
Displaying drugs 176 - 200 of 12995 in total