Matrix Metalloproteinase Inhibitors

Name
Matrix Metalloproteinase Inhibitors
Accession Number
DBCAT001461
Description

Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.

Drugs
DrugDrug Description
IlomastatIlomastat is a broad-spectrum matrix metalloproteinase inhibitor.
PrinomastatInvestigated for use/treatment in brain cancer, lung cancer, and prostate cancer.
S-3304S-3304 has been used in trials studying the treatment of Lung Cancer, Solid Tumors, Non Small Cell Lung Cancer, Stage IIIB Non Small Cell Lung Cancer, and Stage IIIA Non...
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamideNot Available
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamideNot Available
CGS-27023Not Available
AbametapirA pediculicide metalloproteinase used topically in the treatment of head lice infection.
Drugs & Drug Targets
DrugTargetType
IlomastatLethal factortarget
IlomastatDisintegrin and metalloproteinase domain-containing protein 28target
IlomastatAggrecan core proteintarget
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamideStromelysin-1target
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamideStromelysin-1target
CGS-27023Macrophage metalloelastasetarget
CGS-27023Interstitial collagenasetarget
AbametapirCytochrome P450 1A2enzyme
AbametapirCytochrome P450 3A4enzyme
AbametapirCytochrome P450 2B6enzyme