Malaria, Cerebral (DBCOND0000200)

Identifiers

Synonyms

Cerebral Malaria / Plasmodium falciparum malaria with cerebral complications / Cerebral malaria (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Artesunate	Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.	Malaria protein EXP-1target Cytochrome P450 2A6enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A9enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Organic anion transporter 3transporter Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01589289	Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC	No drug interventions	diagnostic	3	completed
NCT01660672	Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria	Levetiracetam	treatment	1 / 2	completed
NCT00697164	Randomized Trial of Erythropoietin During Cerebral Malaria	Epoetin beta Erythropoietin	treatment	2 / 3	unknown_status
NCT00113854	Mannitol as Adjunct Therapy for Childhood Cerebral Malaria	Mannitol	treatment	3	unknown_status
NCT00124267	Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria	Quinine	treatment	3	unknown_status
NCT01982812	A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM	Levetiracetam	treatment	2	completed
NCT00292942	Study of the Safety of Intravenous Artesunate	Artesunate Mannitol	treatment	1	completed
NCT05478720	DON in Pediatric Cerebral Malaria	6-diazo-5-oxo-L-norleucine	treatment	1 / 2	recruiting
NCT00292929	Study of the Safety of Intravenous Artesunate	Artesunate	treatment	1	completed
NCT00658450	Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria	No drug interventions	treatment	Not Available	completed
NCT01388842	Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children	Nitric Oxide Nitrogen	treatment	2	completed
NCT03300648	Treating Brain Swelling in Pediatric Cerebral Malaria	No drug interventions	treatment	3	completed