Spasticity (DBCOND0020611)

Identifiers

Synonyms
Spasticity (finding) / Muscle spasticity / Spasticity (qualifier value) / Spasticity muscle

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Baclofen
A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
Botulinum toxin type A
A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
Clostridium botulinum
Not Annotated
No drug targets
Dantrolene
A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis.
Tolperisone
A muscle relaxant used to relieve spasticity after stroke in adults.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02718690
Importance of the Current Density in TENSNo drug interventionstreatmentNot Availablecompleted
NCT01945684
A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticitytreatment3completed
NCT02170779
Developing and Testing a Comprehensive MS Spasticity Management ProgramNo drug interventionstreatment2completed
NCT01712087
Long-term Surveillance of the MedStream Programmable Infusion SystemNo drug interventionsNot AvailableNot Availableterminated
NCT05179577
A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosistreatment3not_yet_recruiting
NCT01964547
A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patientstreatment4completed
NCT00572845
Energy Costs of Spasticity in Spinal Cord Injury: A Pilot InvestigationNo drug interventionsNot AvailableNot Availableterminated
NCT03906305
Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01051128
Continuous Intrathecal Baclofen Infusion for Chronic SpasticityNo drug interventionstreatment3withdrawn
NCT02221011
The Effect of Extracorporeal Shock Wave Therapy on SpasticityNo drug interventionstreatmentNot Availablecompleted
NCT00337688
Power Wheelchair Joystick Use in Spastic Cerebral PalsyNo drug interventionsNot AvailableNot Availablecompleted
NCT03999788
miR-142-3p as Potential Biomarker of Synaptopathy in MSNo drug interventionstreatmentNot Availablerecruiting
NCT02199015
Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral PalsyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05311215
Phase II Study to Assess Safety, Pharmacokinetics and Efficacy of SL-1002 for Limb SpasticityNo drug interventionstreatment2active_not_recruiting
NCT01844232
One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticitytreatment3completed
NCT01457352
Efficacy and Safety of SPARC0921 in Subjects With SpasticityNo drug interventionstreatment3completed
NCT02261142
Efficacy and Cost-effectiveness of Spasticity Treatment With Multifocal TENSNo drug interventionstreatmentNot Availablecompleted
NCT02127606
The Effect of Whole Body Vibration on Spasticity in Persons With Spinal Cord InjuryNo drug interventionstreatmentNot Availableunknown_status
NCT04340336
Study Assessing Adult Subjects Affected With Upper and/or Lower Limb Spasticity Treated With Botulinum Neurotoxin Type ANo drug interventionsNot AvailableNot Availablecompleted
NCT02400619
Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCTtreatment1completed
NCT03302741
Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordingstreatment4completed
NCT03546517
Effectiveness of Dry Needling (DNHS Technique) in Patients With Chronic StrokeNo drug interventionstreatmentNot Availablecompleted
NCT05422716
"Epidural Spinal Cord Stimulation: Addressing Spasticity and Motor Function"No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01817816
Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01111435
A Prospective Study of Spasticity in Individuals With Multiple SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05885139
Exopulse Mollii Suit, Motor Functions & CP Children With Cerebral PalsyNo drug interventionstreatmentNot Availablerecruiting
NCT02470325
The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patientstreatment2unknown_status
NCT04752774
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.treatment1 / 2active_not_recruiting
NCT03129529
Comparing the Effect of Focused and Radial Extracorporeal Shock Waves on Post-stroke HypertoniaNo drug interventionstreatmentNot Availablecompleted
NCT02718989
Modulation of H-reflex After Application of Electric Currents in Healthy PeopleNo drug interventionstreatmentNot Availableunknown_status
NCT04099667
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticitytreatment2 / 3active_not_recruiting
NCT01313767
MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticitytreatment3completed
NCT03240601
Spinal Cord Stimulation to Augment Activity Based TherapyNo drug interventionstreatmentNot Availablecompleted
NCT05674604
Cryoneurolysis for Knee and Shoulder Pain in an Inpatient SettingNo drug interventionsNot AvailableNot Availablerecruiting
NCT00367068
Dutch National ITB Study in Children With Cerebral Palsytreatment3completed
NCT00178646
Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticitytreatment4completed
NCT02275312
ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb SpasticityNo drug interventionsNot AvailableNot Availablecompleted
NCT01523210
DTI Study of the Influence of Physiotherapy on Distribution of BoNT in Spastic MuscleNo drug interventionsNot AvailableNot Availablecompleted
NCT04312581
Extracorporeal Shock Wave Therapy on Wrist and Hand Functions in Spastic Chronic Stroke PatientsNo drug interventionstreatmentNot Availablecompleted
NCT00681538
A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)supportive_care3completed
NCT00914290
A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosistreatment2completed
NCT04446702
Retrospective Real-Life Study From One Brazilian Reference Center Assessing Long-Term Experience In The Treatment Of Adult Spasticity With AbobotulinumtoxinANo drug interventionsNot AvailableNot Availablecompleted
NCT02002884
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsytreatment3completed
NCT01839279
A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in Healthy Men and Women Using a Blinded ECG Evaluator: A Thorough ECG Trialtreatment2completed
NCT01610687
A Long-term Safety Extension Study of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosistreatment3completed
NCT01743651
Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosistreatment3completed
NCT02334683
Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal DystoniaNo drug interventionsdiagnosticNot Availablecompleted
NCT02268461
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke SpasticityNo drug interventionstreatmentNot Availablecompleted
NCT01681888
Surface EMG Biofeedback for Children With Cerebral PalsyNo drug interventionstreatmentNot Availablewithdrawn
NCT01797185
Safety Study of SPARC1104No drug interventionsother3completed
NCT01606137
A Study of the Long-term Safety of Sativex Usetreatment3completed
NCT02566837
Use of Ultrasound in Injections of Botulinum ToxinNo drug interventionstreatmentNot Availablecompleted
NCT02291159
Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in StrokeNo drug interventionstreatmentNot Availablecompleted
NCT01915459
Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticitytreatment3completed
NCT00607542
Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticitytreatment1 / 2completed
NCT05447299
Neuromusculoskeletal Modeling of Muscle SpasticityNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02390206
Study on the Use of Botulinum Toxin Type A in the Treatment of Chronic Post-stroke Spastic PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01879449
Prevalence of Spasticity in Veterans Living in a Long-term Care FacilityNo drug interventionsNot AvailableNot Availablecompleted
NCT00575536
Optical Stimulation in Peripheral Nerves for Select Rhizotomy ProceduresNo drug interventionsNot AvailableNot Availablecompleted
NCT02877836
Functional MRI and DTI in the Preoperative Assessment of DystoniaNo drug interventionsotherNot Availableterminated
NCT02114736
Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroketreatment4unknown_status
NCT02073513
Kinesiotaping the Hand in Cerebral PalsyNo drug interventionstreatmentNot Availablecompleted
NCT05926596
Leg Stretching Using an Exoskeleton on Demand for People With SpasticityNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00464958
One Year Extension Study To Protocol C2/5/TZ:MS-05treatment1 / 2terminated
NCT02228863
Upper Extremity Rehabilitation Using Robot and Botulinum ToxinNo drug interventionstreatment4unknown_status
NCT02027025
Study of SPARC1103 in Subjects With SpasticityNo drug interventionstreatment2completed
NCT01868048
Phase 3, 28-week, Randomized, Double-blind, Placebo-controlled Safety and Efficacy Study of Nabiximols as an add-on Therapy in Subjects With Spasticity Due to Multiple Sclerosis.supportive_care3withdrawn
NCT00776048
Validation of an Obstacle Course Used in Patients With Muscle TightnessNo drug interventionsNot AvailableNot Availableunknown_status
NCT00819065
Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticitytreatment3completed
NCT02203994
Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord InjuryNo drug interventionstreatmentNot Availablecompleted
NCT01444794
Adult Subjects Suffering From Lower Limb Spasticity Following StrokeNo drug interventionsNot AvailableNot Availablecompleted
NCT00282191
Prevalence of Spasticity in Adults With Mental Retardation Living in the CommunityNo drug interventionsNot AvailableNot Availablecompleted
NCT00280280
Botox vs. Baclofen for Upper Limb Spasticitytreatment1terminated
NCT06150729
Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral PalsyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04673240
CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITYNot AvailableNot Availableunknown_status
NCT04815967
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticitytreatment2 / 3active_not_recruiting
NCT00702468
Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosissupportive_care3completed
NCT00711646
A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis.supportive_care3completed
NCT06394310
Dry Needling in Multiple SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT00179114
Vanderbilt University Spasticity Management Program Evaluation Plantreatment4completed
NCT00472914
Use of EMG to Assess Clinical HypertoniaNo drug interventionsNot AvailableNot Availablecompleted
NCT01644123
Reliability of an Algorithm to Diagnose SpasticityNo drug interventionsNot AvailableNot Availablecompleted
NCT01265238
Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootNo drug interventionsNot AvailableNot Availablecompleted