Invasive Candidiasis (DBCOND0032522)

Identifiers

Synonyms
Invasive Candidiases / Candidiasis, Invasive / Invasive candidiasis / Candidal sepsis / Systemic moniliasis / Systemic candida / Disseminated candidiasis (disorder) / Systemic candidiasis / Disseminated candidiasis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Nystatin
A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
Rezafungin
An echinocandin antifungal indicated in patients over 18 years old who have limited or no alternative options for the treatment of candidemia and invasive candidiasis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03450005
ECMM Candida Registry - CandiRegNo drug interventionsNot AvailableNot Availablerecruiting
NCT03090334
A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive CandidiasisNo drug interventionsotherNot Availableterminated
NCT05848492
Efficacy of Prophylactic Fluconazole Therapy in Preterm and Very Low Birth Weight Neonates in Preventing Invasive Fungal Infection.prevention3completed
NCT03468803
Influence of Open and Laparoscopic Abdominal Surgery Involving the Intestinal Tract on Serum 1,3-ß-D-Glucan (BDG) ValuesNo drug interventionsdiagnosticNot Availablecompleted
NCT03667690
Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasistreatment3completed
NCT04148287
An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auristreatment2completed
NCT03717623
Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplantstreatment4recruiting
NCT05421858
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.treatment3not_yet_recruiting
NCT05264571
Early Identification of Candida in Intra-abdominal CandidiasisNo drug interventionsNot AvailableNot Availablecompleted
NCT02244606
Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasistreatment2completed
NCT00413218
Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infectionstreatment3completed
NCT03363841
Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES)treatment3completed
NCT01165320
A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074)treatment2completed
NCT05178862
A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazoletreatment3suspended
NCT03997929
Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)No drug interventionsNot AvailableNot Availablecompleted
NCT01945281
Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064)treatment2terminated
NCT05763251
Comparison of Uncomplicated Candidemia Therapy Duration in ChildrenNo drug interventionstreatmentNot Availablerecruiting
NCT00786903
Candida Spp. in the Lower Respiratory Tract: Harmless Residents or Pathogen?No drug interventionsNot AvailableNot Availablecompleted
NCT02164890
Pharmacokinetics of Micafungin in Patients of Intensive Care UnitsNo drug interventionsother4completed
NCT05707832
A Study of ABCD for Injection in Subjects With Invasive Candidiasis and Invasive Aspergillustreatment3not_yet_recruiting
NCT00520234
Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU)prevention4completed
NCT00607763
Study of Mycamine® in Infants and Toddlers With Fungal Infections to Evaluate Safety and Blood Levels of the DrugNot Available1completed
NCT00670657
CRITIC - Treatment of Candidemia and Invasive Candidiasistreatment4completed
NCT02801682
NOBICS - NOvel BIomarker In Invasive CandidiasiS/Candida SepsisNo drug interventionsNot AvailableNot Availablecompleted
NCT01773876
Empirical Antifungal Treatment in ICUStreatment3completed
NCT00548262
This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasistreatment4completed
NCT02734862
CD101 Compared to Caspofungin Followed by Oral Step Down in Subjects With Candidemia and/or Invasive Candidiasis-Bridging Extensiontreatment2completed
NCT03059992
Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatmenttreatment3completed
NCT01047267
Pharmacokinetics of Anidulafungin on Intensive Care Unit (ICU)No drug interventionsNot AvailableNot Availablecompleted
NCT02841501
Genetic Susceptibility Factors for Candidemia.No drug interventionsNot AvailableNot Availablecompleted
NCT01666769
Pharmacokinetics of Micafungin in Children on Extracorporeal Membrane Oxygenationtreatment1completed
NCT02220790
BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric CandidemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01490684
Invasive Candidiasis in Saudi ICUsNo drug interventionsNot AvailableNot Availablecompleted
NCT06456151
Invasive Candidiasis in Critical CareNo drug interventionsNot AvailableNot Availablerecruiting
NCT02491151
Variability of Fluconazole Concentration in Critically Ill PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01045798
Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067)treatment2terminated
NCT01716988
Pharmacokinetics of Micafungin in Critically Ill PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00189709
Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemiatreatment3completed
NCT00250432
A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED)treatment3completed
NCT04368559
Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantationprevention3recruiting
NCT00672841
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) PatientstreatmentNot Availablecompleted
NCT01438216
Anidulafungin Pharmacokinetics in Intensive Care Unit PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03906916
Comparison of Two Diagnostic Tests in Patients With Suspected Invasive Candidiasis in Internal Medicine Wards and Who Are Currently Timely Treated With Micafungindiagnostic4terminated
NCT00608335
Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drugother1completed
NCT05496725
Evaluate Bioequivalence of Micafungin (50mg/Vial)other4completed
NCT03538912
Early Discontinuation of Empirical Antifungal Therapy and BiomarkersNo drug interventionstreatmentNot Availablerecruiting
NCT04225195
Amphotericin B Cholesteryl Sulfate Complex for Injection(ABCD) in the Treatment of Invasive Candidiasis and Invasive Aspergillosistreatment2unknown_status
NCT01213823
Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With EchinocandinsNo drug interventionsNot AvailableNot Availableterminated
NCT00689338
Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Studytreatment3completed