Clostridium Difficile Infection (CDI) (DBCOND0076400)

Identifiers

Synonyms
Clostridium Difficile Infections / Infections, Clostridium Difficile / Clostridium Difficile Infection / Clostridial disease / Clostridioides difficile infection / Infection caused by Clostridioides difficile (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Demeclocycline
A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
Teicoplanin
A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06237452
VE303 for Prevention of Recurrent Clostridioides Difficile Infectionprevention3recruiting
NCT06398379
Virus as Treatment of C. Difficile Infection (VISION)No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06030245
Clostridioides Difficile Infection: Analyzing CLInic Evolution and Bacterial ClearanceNo drug interventionsNot AvailableNot Availablerecruiting
NCT01957761
Molecular Epidemiology of Clostridium Difficile Infections in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT06311006
Safety Registry of a Fecal Microbiota Transplant CohortNo drug interventionsNot AvailableNot Availablerecruiting
NCT05714566
Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06107569
Treatment of CDI and Recurrence With Fecal Microbiota Transplant Using Promicrobiomatreatment3not_yet_recruiting
NCT05256693
Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantprevention3not_yet_recruiting
NCT05430269
Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT01716533
Evaluation of the Immune Response to Clostridium Difficile in Adults With Clostridium Difficile Infection (CDI)No drug interventionsbasic_scienceNot Availablecompleted
NCT02692651
A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infectionstreatment4completed
NCT02437591
Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI)treatment4completed
NCT03244644
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD3)No drug interventionstreatment3completed
NCT04121169
Treatment of Mild-moderate Clostridium Difficile Infection (CDI)No drug interventionstreatment2recruiting
NCT04070352
Evaluation of Fidaxomicin in the Treatment of Clostridium Difficile Infection (CDI)Not AvailableNot Availablewithdrawn
NCT02951702
Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibioticsprevention4completed
NCT01222702
Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD)treatment2completed
NCT03005379
Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)prevention2 / 3terminated
NCT02996487
Screening to Prophylax Against Clostridium Difficile Infection -prevention4completed
NCT03643887
Phase II Trial of Fecal Microbiota Transplant (FMT) for VRE and CRE PatientsNo drug interventionsprevention2withdrawn
NCT03795233
Fecal Microbiota Transplant for Primary CDItreatment1 / 2terminated
NCT05703477
The Dynamic Fluctuation of Donor Microbiota Affects the Prognosis of Fecal Microbiota Transplantation for C. Difficile InfectionNo drug interventionstreatmentNot Availablecompleted
NCT02570477
FMT for Moderate to Severe CDI: A Randomised Study With Concurrent Stool Microbiota AssessmenttreatmentNot Availableactive_not_recruiting
NCT03827447
Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficiletreatment1completed
NCT01077245
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile InfectionsNo drug interventionstreatment2withdrawn
NCT03053505
A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile InfectiontreatmentNot Availableunknown_status
NCT02255305
FMT Versus Antimicrobials for Initial Treatment of Recurrent CDItreatment2terminated
NCT03183128
ECOSPOR III - SER-109 Versus Placebo in the Treatment of Adults With Recurrent Clostridium Difficile InfectionNo drug interventionstreatment3completed
NCT03182907
Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001)prevention3completed
NCT02223715
Prospective Observational Study of Clostridium Difficile Infection in Asian Pacific CountriesNo drug interventionsNot AvailableNot Availablecompleted
NCT01704937
Fecal Microbiota Transplant (FMT) for Relapsing C. Difficile Infection in Adults and Children Using a Frozen Inoculumtreatment1completed
NCT01972932
Study of Bio-K+® in the Reduction of the Risk of Clostridium Difficile Infection and Antibiotic Associated DiarrheaNo drug interventionsprevention4terminated
NCT01560832
Descriptive Epidemiology of Clostridium Difficile Infection in Hospitalized Adult Patients in the Asia Pacific RegionNo drug interventionsNot AvailableNot Availablecompleted
NCT02301000
IMT for Primary Clostridium Difficile Infectiontreatment2 / 3terminated
NCT02237859
Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infectionprevention4unknown_status
NCT03462459
Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infectionprevention2completed
NCT03141775
Incidence and Economic Burden of Clostridium Difficile Infections (CDI) in the German Health Care System (IBIS)No drug interventionsNot AvailableNot Availableunknown_status
NCT04138706
Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infectionprevention3active_not_recruiting
NCT04960306
Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infectiontreatment3not_yet_recruiting
NCT01670149
Rifaximin for Preventing Relapse of Clostridium Associated Diarrhoeaprevention4completed
NCT03804736
Fecal Microbiota Transplant by Oral Capsules With Lactobacilli for Recurrent Clostridium Difficile InfectiontreatmentNot Availableunknown_status
NCT03268213
Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate ColitisNo drug interventionstreatment0completed
NCT04014413
Safety and Efficacy of Fecal Microbiota TransplantationNo drug interventionstreatmentNot Availablerecruiting
NCT02991417
Oral Vaccination Against Clostridium Difficile InfectionNo drug interventionsprevention1terminated
NCT02865616
MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI)treatment1completed
NCT02981316
Treatment of Recurrent Clostridium Difficile Infection With RBX7455No drug interventionstreatment1completed
NCT02086916
Novel Biomarkers to Predict Outcome in Clostridium Difficile InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02092935
A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)treatment2completed
NCT04317963
Real-world Evaluation of Bezlotoxumab for the Management of Clostridioides Difficile InfectionNot AvailableNot Availablecompleted
NCT01296386
An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84No drug interventionsprevention1completed
NCT01513239
A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)treatment3completed
NCT03712722
Fecal Microbiota Transplantation (FMT) for Clostridium DifficileNo drug interventionsNot AvailableNot Availablerecruiting
NCT03030248
Vancomycin for C Difficile NAAT+/EIA- Hematology Oncology Patientstreatment2completed
NCT05192148
Seroprevalence of Antibodies to Surface Antigens and Toxins of Clostridioides DifficileNo drug interventionsotherNot Availablerecruiting
NCT03621657
The GRAFT Study: Gut RecolonizAtion by Fecal TransplantationNo drug interventionstreatment2completed
NCT02327520
Clostridium Difficile Infection: the First Report in Southeast Asia by 2010 Nationwide StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01914731
Fecal Microbiota Transplant for Relapsing Clostridium Difficile Infection in Adults and Children Using a Frozen Encapsulated Inoculumtreatment1completed
NCT03848689
FQ Restriction for the Prevention of CDINo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02461901
Does Fidaxomicin Therapy Reduce Spread of Clostridium Difficile?No drug interventionsNot AvailableNot Availablecompleted
NCT06367504
A Study to Assess the Effect of Doctor's Biome Medical Food in Individuals With Clostridium Difficile InfectionNo drug interventionsotherNot Availablenot_yet_recruiting
NCT03654872
Clostridium Difficile Virulence Mechanism Study (CDVM Study)No drug interventionsNot AvailableNot Availableunknown_status
NCT04940468
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in OncologyNo drug interventionspreventionNot Availablerecruiting
NCT03349268
Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated InfectionNo drug interventionspreventionNot Availablecompleted
NCT03388268
TOX NEG Trial: Clostridium Difficile Diagnosis and Treatmentother4completed
NCT04305769
Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)treatment2recruiting
NCT04090346
Fecal Microbiota Transplanttreatment4completed
NCT01887912
Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile InfectionNo drug interventionsprevention3terminated
NCT01987895
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrheatreatment3completed
NCT03824795
Study to Assess Safety, Tolerability and Efficacy of Incremental Doses of MGB-BP-3 in Patients With CDADtreatment2completed
NCT01946750
Predictive Value of the Immune Response of the Host in Clostridium Difficile InfectionspreventionNot Availablecompleted
NCT04014608
Protocol for Admission Toxigenic C. Difficile SurveillanceNo drug interventionsNot AvailableNot Availablecompleted
NCT03834038
Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridium Difficile InfectiontreatmentNot Availableunknown_status
NCT02106338
Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123.treatment1completed
NCT01372943
Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile InfectiontreatmentNot Availableterminated
NCT04100603
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Clostridoides Difficile InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02784002
A Study of Ridinilazole (SMT19969) Compared With Fidaxomicin for the Treatment of Clostridium Difficile Infection (CDI)treatment2completed
NCT03466502
Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibioticsprevention4completed
NCT03105479
Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD)treatment2 / 3terminated
NCT00772954
Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and ImmunogenicityNo drug interventionstreatment1terminated
NCT01822977
The Impact of Proton Pump Inhibitors on the Fecal MicrobiomeNot Available1completed
NCT01942447
Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile ColitistreatmentNot Availableunknown_status
NCT02589847
Microbiota Restoration Therapy for Recurrent Clostridium Difficile InfectionNo drug interventionstreatment2completed
NCT01842347
Treatment of C. Difficile Infection With Fecal Microbiota Transplantation (FMT)No drug interventionstreatmentNot Availablewithdrawn
NCT02686645
Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infectiontreatment2 / 3unknown_status
NCT02707198
Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of KefirNo drug interventionsprevention2terminated
NCT01597505
Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)treatment3completed
NCT01983683
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrheatreatment3completed
NCT03350711
A Screening and Recruitment Study in Adults Expressing Interest in the Emory Microbiota Enrichment ProgramNo drug interventionsNot AvailableNot Availablesuspended
NCT01598311
A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006)treatment3completed
NCT03200093
Oral Vancomycin for Preventing Clostridium Difficile Recurrenceprevention4terminated
NCT02214771
Description of the Use of fidAxomicin in Hospitalized Patients With Documented Clostridium diFficile iNfection and of the managEment of These PatientsNot AvailableNot Availablecompleted
NCT04012788
CDI Synbiotic StudyNo drug interventionspreventionNot Availableunknown_status
NCT01905709
Fecal Microbiota Transplantation for C Diff InfectionNo drug interventionstreatmentNot Availableunknown_status
NCT02557685
Gut Microbiota Changes After Fecal Microbiota Transplantationtreatment2unknown_status
NCT01930032
Pathogenic Mechanisms in C Diff Infection and ColitisNo drug interventionsNot AvailableNot Availablecompleted
NCT01241552
A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)treatment3completed
NCT03829475
ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDItreatment2active_not_recruiting
NCT04247542
ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infectiontreatment2completed
NCT02830542
SER-262 Versus Placebo in Adults With Primary Clostridium Difficile Infection to Prevent RecurrenceNo drug interventionsprevention1completed
NCT03497806
Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Clostridium Difficile InfectionNo drug interventionstreatment2completed
NCT03586206
Relationship Between C. Difficile Toxins' Serum Level With C. Difficile InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02464306
Fidaxomicin Versus Standard of Care Therapy in Solid Organ Transplant Recipients With Clostridium Difficile Infectiontreatment4withdrawn
NCT03925636
Specific Carbohydrate Diet for Clostridium DifficileNo drug interventionstreatmentNot Availablecompleted
NCT02326636
Fecal Microbiota Transplant for Recurrent Clostridium Difficile InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT02399618
Freeze-dried, Capsulized FMT for RCDItreatment1unknown_status
NCT01295918
Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized ChildrenNo drug interventionsprevention3completed
NCT03931941
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS)No drug interventionstreatment3completed
NCT01818141
Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycintreatment4completed
NCT03562741
Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium DifficileNo drug interventionstreatmentNot Availablerecruiting
NCT03788434
Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infectionprevention2completed
NCT02743234
Fecal Microbiota Transplantation for Relapsing Clostridium Difficile Infectiontreatment3completed
NCT04567134
Clostridioides Difficile Infection - a Prospective Nationwide Epidemiologic Study in KoreaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02968758
Validation of the GenePOC CDiff Assay for the Detection of the Toxin B Gene From Toxigenic Clostridium Difficile StrainsNo drug interventionsdiagnosticNot Availablecompleted
NCT01958463
Transplantation of Fecal Microbiota for Clostridium Difficile InfectionNo drug interventionstreatment3unknown_status
NCT00563186
Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled TrialNo drug interventionspreventionNot Availablecompleted
NCT04075422
Bezlotoxumab - in "Real Life" - During the First Episode of Clostridium Difficile Infection in Patients With High Risk of Recurrence.Not AvailableNot Availablecompleted
NCT01896830
Study of a Candidate Clostridium Difficile Toxoid Vaccine in Healthy Adult Subjects Aged 40 to 75 Years in JapanNo drug interventionsprevention1 / 2completed
NCT04187430
Validation of a Prediction Score for Recurrent C. Difficile Infection: Implementation for Treatment Algorithm StrategiesNo drug interventionsNot AvailableNot Availableunknown_status
NCT02395848
Efficacy of 30-day Duration of Fidaxomicin for Recurrent C. Difficile Infectiontreatment3terminated
NCT04698148
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT01230957
Study of Different Formulations of a Clostridium Difficile Toxoid Vaccine Given at Three Different Schedules in AdultsNo drug interventionsprevention2completed
NCT01259726
Safety and Efficacy Study of VP20621 for Prevention of Recurrent Clostridium Difficile InfectionNo drug interventionsprevention2completed
NCT03503474
COMBACTE-CDI Understanding the Burden of C. Difficile InfectionNo drug interventionsNot AvailableNot Availablecompleted
NCT03065374
Treatment for Clostridium-difficile Infection With IMM529No drug interventionstreatment1 / 2terminated
NCT02016820
Effect of Acid Suppression Medication on Pediatric Microbiomebasic_scienceNot Availableterminated
NCT03592082
Use of Bismuth Subsalicylate in Clostridium Difficile Colitistreatment4withdrawn
NCT04259931
PROSPECTIVE STUDY OF PREDISPOSING FACTORS OF REFRACTARY Clostridium Difficile INFECTION. INFLUENCE OF THE GUT MICROBIOMANo drug interventionsNot AvailableNot Availableunknown_status
NCT03710694
Safety and Efficacy of DAV132 in Patients at High-Risk for Clostridium Difficile Infection (CDI)No drug interventionspreventionNot Availablecompleted
NCT01085591
Study of CB-183,315 in Participants With Clostridium Difficile Infectiontreatment2completed
NCT03090191
Clostridium Difficile Vaccine Efficacy TrialNo drug interventionsprevention3completed
NCT04801862
Natural History of Clostridioides Difficile InfectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03106844
The ICON Study: Outcomes After FMT for Patients With IBD and CDItreatment1 / 2completed
NCT05008640
Creation of an E-toileting Log Through Classification of the Physical Properties of Stool and Urine Using TrueLoo™No drug interventionsNot AvailableNot Availablecompleted
NCT03250104
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-NegativesNo drug interventionsNot AvailableNot Availablecompleted
NCT03025672
Evaluation of the Cost of a Nosocomial Infection With Clostridium DifficileNo drug interventionsNot AvailableNot Availablecompleted
NCT01552668
Fidaxomicin to Prevent Clostridium Difficile Colonizationprevention4withdrawn
NCT03107169
Treatment of Initial Clostridium Difficile InfectiontreatmentNot Availablecompleted
NCT01398969
Multi-Centre Trial of Fresh vs. Frozen-and-Thawed FMT for Recurrent CDINo drug interventionsprevention2completed
NCT04885946
Fecal Microbiota Transplantation for Early Clostridioides Difficile InfectionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02053181
Study to Investigate the Pharmacokinetics and Safety of Cadazolid in Patients With Clostridium Difficile InfectionNot Available1completed
NCT04000555
Oral Vancomycin for Secondary Prophylaxis of Clostridium Difficile Infection (CDI)prevention4terminated
NCT03325855
Fecal Microbiota Transplant National RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT03796650
Fecal Transplantation for Primary Clostridium Difficile Infectiontreatment3unknown_status
NCT02053350
Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infectiontreatment2terminated
NCT00772343
Study of a Clostridium Difficile Toxoid Vaccine (ACAM-CDIFF™) in Subjects With Clostridium Difficile InfectionNo drug interventionstreatment2completed
NCT02592343
A Prospective Trial of Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infectiontreatment2completed