Anthrax (DBCOND0000387)

Identifiers

Synonyms

Anthrax Infection / Anthrax, unspecified / Anthrax (disorder) / Bacillus anthracis infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Benzylpenicillin	A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 4transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 4A1transporter Solute carrier organic anion transporter family member 3A1transporter Solute carrier organic anion transporter family member 1B1transporter Penicillin-binding protein 3target Organic anion transporter 3target Solute carrier family 15 member 1target Solute carrier family 15 member 2target Beta-lactamase TEMenzyme Albumincarrier Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 1Ctarget
Demeclocycline	A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.	30S ribosomal proteintarget Vasopressin V2 receptortarget
Doxycycline	A tetracycline antibiotic used to treat a wide variety of bacterial infections.	Solute carrier family 22 member 6transporter Cytochrome P450 3A4enzyme ATP-binding cassette sub-family B member 5transporter Albumincarrier 30S ribosomal proteintarget
Phenoxymethylpenicillin	A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.	Penicillin-binding protein 1Atarget MecA PBP2' (penicillin binding protein 2')target D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin acylasetarget Solute carrier family 15 member 1target
Procaine benzylpenicillin	A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.	No drug targets
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01979406	A Phase 1 Ascending Dose Study to Assess the Safety and Immunogenicity of Adenovirus Anthrax Vector Candidate Vaccines	Anthrax vaccine	prevention	1	completed
NCT00050310	Natural History of Anthrax: a Study of Primary Infected, Recovered, and Exposed Individuals (SPoRE); and Evaluation of AVA-Vaccinated Recipients	No drug interventions	Not Available	Not Available	recruiting
NCT04660201	Anthrax AV7909 Liquid vs Lyophilized	No drug interventions	prevention	1	completed
NCT00114621	Anthrax Vaccine Clinical Trials	Anthrax vaccine	treatment	1	completed
NCT01265745	Dose Escalation Study of Valortim® (MDX-1303) Administered Intravenously (IV) in Healthy, Normal Subjects	MDX-1303	treatment	1	completed
NCT00964561	Ph1 Study of Valortim and Ciprofloxacin in Humans	Ciprofloxacin MDX-1303	treatment	1	suspended
NCT03088111	An Open Label Field Study of Anthim (Obiltoxaximab) in Subjects Exposed to B. Anthracis	Obiltoxaximab	treatment	4	not_yet_recruiting
NCT04067011	Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study	Ciprofloxacin Doxycycline	prevention	2	completed
NCT04320485	Evaluation of the Clinical Specificity of the Active Anthrax Detect™ Plus (AAD Plus) Lateral Flow Immunoassay (LFI)	No drug interventions	Not Available	Not Available	completed
NCT01624532	A Study to Assess Dose-Response, Efficacy (Immunogenicity) and the Safety of GC1109	No drug interventions	prevention	2	completed
NCT02655549	A Study of Anthrax Vaccines Px563L and RPA563 in Healthy Adult Subjects	No drug interventions	prevention	1	completed
NCT04148118	A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Anthrax Vaccine in Healthy Adults	Anthrax vaccine	prevention	1	completed
NCT00100724	Trial of rPA-102 Vaccine in Healthy Adult Volunteers	Anthrax vaccine	prevention	2	completed
NCT00123396	VHA Clinicians and Bioterror Events: Interactive Web-based Learning	No drug interventions	Not Available	Not Available	completed
NCT03498027	Febrile Whole Blood Specimen Collection and Testing	No drug interventions	Not Available	Not Available	completed
NCT02239172	PA83-FhCMB Plant-Derived Recombinant Protective Antigen (rPA) Anthrax Vaccine	No drug interventions	prevention	1	completed
NCT03569514	Observational Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Patients With Systemic Anthrax	Anthrax immune globulin human	Not Available	Not Available	not_yet_recruiting
NCT01770743	A Phase 2 Safety and Immunogenicity Study for an Anthrax Vaccine Using 3 Schedules and Two Dose Levels	Anthrax vaccine	prevention	2	completed
NCT00063843	Anthrax-rPA: Safety, Tolerability, Immunogenicity	Anthrax vaccine	prevention	1	completed
NCT05997264	Anthrax AV7909 Boost Evaluation Study	No drug interventions	other	2	active_not_recruiting
NCT01453907	Single Dose, Weight-Based, Dose-Escalation Study With Intravenous ETI-204 in Adult Volunteers	Obiltoxaximab	treatment	1	completed
NCT01491607	Immunogenicity and Safety Study of a Three-Dose BioThrax® Regimen for Post-Exposure Prophylaxis in Healthy Adults	Anthrax vaccine	treatment	3	completed
NCT01753115	Ciprofloxacin BioThrax Co-Administration Study	Anthrax vaccine Ciprofloxacin	treatment	2	completed
NCT05672875	Evaluation of the SRI B. Anthracis Lethal Factor Diagnostic System	No drug interventions	Not Available	Not Available	terminated
NCT00964834	Ph1 Study of Valortim and Doxycycline in Humans	Doxycycline MDX-1303	treatment	1	terminated
NCT00057525	A New Anthrax Vaccine Administered by the Intramuscular (IM) Route in Healthy Adults	No drug interventions	prevention	1	completed
NCT03518125	BARDA Securing Anthrax Immunity For the Elderly	Anthrax vaccine	prevention	2	completed
NCT01867957	Efficacy and Safety of Anthrax Vaccine, GC1109	No drug interventions	prevention	1	completed
NCT03877926	VELOCITY: An Anthrax Vaccine Clinical Study	Anthrax vaccine	prevention	3	completed
NCT06365073	A Case-control Study on the Clinical Characteristics of 28-day and 90-day Death From Severe Anthrax	No drug interventions	Not Available	Not Available	recruiting
NCT00031291	Plasmapheresis of Anthrax-Vaccinated Subjects for Production of Anthrax Immune Globulin	No drug interventions	Not Available	Not Available	completed
NCT01202695	Safety and Pharmacokinetics Study of Human Monoclonal Antibody (AVP-21D9)	AVP-21D9	treatment	1	completed
NCT00845650	Safety and Pharmacokinetics Study of Anthrax Immune Globulin Intravenous (AIGIV)	Human immunoglobulin G	treatment	1 / 2	completed