Gamma-aminobutyric acid receptor subunit theta
Details
- Name
- Gamma-aminobutyric acid receptor subunit theta
- Synonyms
- GABA(A) receptor subunit theta
- GABAAR subunit theta
- Gene Name
- GABRQ
- UniProtKB Entry
- Q9UN88Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0064091|Gamma-aminobutyric acid receptor subunit theta MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPT EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
- Number of residues
- 632
- Molecular Weight
- 71986.855
- Theoretical pI
- 5.76
- GO Classification
- FunctionsGABA-gated chloride ion channel activity / neurotransmitter receptor activity / neurotransmitter transmembrane transporter activityComponentstransmembrane transporter complex
- General Function
- Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217)
- Specific Function
- Gaba-a receptor activity
- Pfam Domain Function
- Signal Regions
- 1-21
- Transmembrane Regions
- 269-289 298-315 327-347 612-632
- Cellular Location
- Postsynaptic cell membrane
- Gene sequence
>lcl|BSEQ0012500|Gamma-aminobutyric acid receptor subunit theta (GABRQ) ATGGGCATCCGAGGCATGCTGCGAGCCGCAGTGATCCTGCTGCTCATCAGGACCTGGCTC GCGGAGGGCAACTACCCCAGTCCCATCCCGAAATTCCACTTCGAGTTCTCCTCTGCTGTG CCCGAAGTCGTCCTGAACCTCTTCAACTGCAAAAATTGTGCAAATGAAGCTGTGGTTCAA AAGATTTTGGACAGGGTGCTGTCAAGATACGATGTCCGCCTGAGACCGAATTTTGGAGGT GCCCCTGTGCCTGTGAGAATATCTATTTATGTCACGAGCATTGAACAGATCTCAGAAATG AATATGGACTACACGATCACGATGTTTTTTCATCAGACTTGGAAAGATTCACGCTTAGCA TACTATGAGACCACCCTGAACTTGACCCTGGACTATCGGATGCATGAGAAGTTGTGGGTC CCTGACTGCTACTTTCTGAACAGCAAGGATGCTTTCGTGCATGATGTGACTGTGGAGAAT CGCGTGTTTCAGCTTCACCCAGATGGAACGGTGCGGTACGGCATCCGACTCACCACTACA GCAGCTTGTTCCCTGGATCTGCATAAATTCCCTATGGACAAGCAGGCCTGCAACCTGGTG GTAGAGAGCTATGGTTACACGGTTGAAGACATCATATTATTCTGGGATGACAATGGGAAC GCCATCCACATGACTGAGGAGCTGCATATCCCTCAGTTCACTTTCCTGGGAAGGACGATT ACTAGCAAGGAGGTGTATTTCTACACAGGTTCCTACATACGCCTGATACTGAAGTTCCAG GTTCAGAGGGAAGTTAACAGCTACCTTGTGCAAGTCTACTGGCCTACTGTCCTCACCACT ATTACCTCTTGGATATCGTTTTGGATGAACTATGATTCCTCTGCAGCCAGGGTGACAATT GGCTTAACTTCAATGCTCATCCTGACCACCATCGACTCACATCTGCGGGATAAGCTCCCC AACATTTCCTGTATCAAGGCCATTGATATCTATATCCTCGTGTGCTTGTTCTTTGTGTTC CTGTCCTTGCTGGAGTATGTCTACATCAACTATCTTTTCTACAGTCGAGGACCTCGGCGC CAGCCTAGGCGACACAGGAGACCCCGAAGAGTCATTGCCCGCTACCGCTACCAGCAAGTG GTGGTAGGAAACGTGCAGGATGGCCTGATTAACGTGGAAGACGGAGTCAGCTCTCTCCCC ATCACCCCAGCGCAGGCCCCCCTGGCAAGCCCGGAAAGCCTCGGTTCTTTGACGTCCACC TCCGAGCAGGCCCAGCTGGCCACCTCGGAAAGCCTCAGCCCACTCACTTCTCTCTCAGGC CAGGCCCCCCTGGCCACTGGAGAAAGCCTGAGCGATCTCCCCTCCACCTCAGAGCAGGCC CGGCACAGCTATGGTGTTCGCTTTAATGGTTTCCAGGCTGATGACAGTATTATTCCTACC GAAATCCGCAACCGTGTCGAAGCCCATGGCCATGGTGTTACCCATGACCATGAAGATTCC AATGAGAGCTTGAGCTCGGATGAGCGCCATGGCCATGGCCCCAGTGGGAAGCCCATGCTT CACCATGGCGAGAAGGGTGTGCAAGAAGCAGGCTGGGACCTTGATGACAACAATGACAAG AGCGACTGCCTTGCCATTAAGGAGCAATTCAAGTGTGATACTAACAGTACCTGGGGCCTT AATGATGATGAGCTCATGGCCCATGGCCAAGAGAAGGACAGTAGCTCAGAGTCTGAGGAT AGTTGCCCCCCAAGCCCTGGGTGCTCCTTCACTGAAGGGTTCTCCTTCGATCTCTTTAAT CCTGACTACGTCCCAAAGGTCGACAAGTGGTCCCGGTTCCTCTTCCCTCTGGCCTTTGGG TTGTTCAACATTGTTTACTGGGTATACCATATGTATTAG
- Chromosome Location
- X
- Locus
- Xq28
- External Identifiers
Resource Link UniProtKB ID Q9UN88 UniProtKB Entry Name GBRT_HUMAN GenBank Protein ID 7861736 GenBank Gene ID AF189259 GeneCard ID GABRQ HGNC ID HGNC:14454 KEGG ID hsa:55879 NCBI Gene ID 55879 - General References
- Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER: GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci. 2000 May 15;20(10):3588-95. [Article]
- Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR: The DNA sequence of the human X chromosome. Nature. 2005 Mar 17;434(7031):325-37. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Bonnert TP, McKernan RM, Farrar S, le Bourdelles B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ: theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9891-6. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Gamma-aminobutyric acid receptor subunit theta (Humans) protein primaryGABA(A) Receptor (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Ethanol approved unknown target Details Desflurane approved yes target positive allosteric modulator Details Alprazolam approved, illicit, investigational yes target positive allosteric modulator Details Butabarbital approved, illicit yes target positive allosteric modulator Details Chlordiazepoxide approved, illicit, investigational yes target positive allosteric modulator Details Clobazam approved, illicit yes target positive allosteric modulator Details Clonazepam approved, illicit yes target positive allosteric modulator Details Clorazepic acid approved, illicit yes target positive allosteric modulator Details Lorazepam approved yes target positive allosteric modulator Details Ethchlorvynol approved, illicit, withdrawn yes target positive allosteric modulator Details Enflurane approved, investigational, vet_approved yes target potentiator Details Temazepam approved, investigational yes target positive allosteric modulator Details Butalbital approved, illicit yes target positive allosteric modulator Details Etomidate approved yes target positive allosteric modulator Details Talbutal approved, illicit yes target positive allosteric modulator Details Pentobarbital approved, investigational, vet_approved yes target positive allosteric modulator Details Meprobamate approved, illicit yes target positive allosteric modulator Details Eszopiclone approved, investigational yes target positive allosteric modulator Details Metharbital withdrawn yes target positive allosteric modulator Details Isoflurane approved, vet_approved yes target positive allosteric modulator Details Primidone approved, vet_approved yes target positive allosteric modulator Details Halazepam approved, illicit, withdrawn yes target positive allosteric modulator Details Propofol approved, investigational, vet_approved yes target positive allosteric modulator Details Diazepam approved, illicit, investigational, vet_approved yes target positive allosteric modulator Details Oxazepam approved yes target positive allosteric modulator Details Methoxyflurane approved, investigational, vet_approved, withdrawn yes target positive allosteric modulator Details Methyprylon approved, illicit, withdrawn yes target positive allosteric modulator Details Halothane approved, vet_approved yes target positive allosteric modulator Details Flumazenil approved yes target positive allosteric modulator Details Estazolam approved, illicit yes target positive allosteric modulator Details Sevoflurane approved, vet_approved yes target agonist Details Glutethimide approved, illicit yes target positive allosteric modulator Details Prazepam approved, illicit yes target positive allosteric modulator Details Quazepam approved, illicit yes target positive allosteric modulator Details Amoxapine approved unknown target binder Details Prasterone approved, investigational, nutraceutical unknown target antagonist Details Thiocolchicoside experimental yes target antagonist Details Stiripentol approved yes target agonistpositive allosteric modulator Details Taurine approved, nutraceutical yes target agonist Details Lamotrigine approved, investigational unknown target antagonistinducer Details Apalutamide approved, investigational no target antagonist Details Brexanolone approved, investigational yes target positive allosteric modulator Details Memantine approved, investigational unknown target binder Details Medroxyprogesterone acetate approved, investigational unknown target inhibitor Details Phenytoin approved, vet_approved unknown target Details Midazolam approved, illicit yes target positive allosteric modulator Details Flurazepam approved, illicit, investigational yes target positive allosteric modulator Details Triazolam approved, investigational yes target positive allosteric modulator Details Bromazepam approved, illicit, investigational yes target positive allosteric modulator Details Nitrazepam approved yes target positive allosteric modulator Details Camazepam experimental, illicit yes target positive allosteric modulator Details Delorazepam experimental, illicit yes target positive allosteric modulator Details Flunitrazepam approved, illicit yes target positive allosteric modulator Details Etizolam experimental yes target positive allosteric modulator Details Medazepam experimental yes target positive allosteric modulator Details Doxefazepam experimental yes target positive allosteric modulator Details Lormetazepam approved yes target positive allosteric modulator Details Nordazepam experimental yes target positive allosteric modulator Details Adinazolam experimental yes target positive allosteric modulator Details Ethyl loflazepate experimental, illicit yes target positive allosteric modulator Details Cloxazolam experimental yes target positive allosteric modulator Details Clotiazepam approved, illicit yes target positive allosteric modulator Details Ketazolam approved yes target positive allosteric modulator Details Cinolazepam experimental yes target positive allosteric modulator Details Brotizolam investigational, withdrawn yes target positive allosteric modulator Details Pinazepam experimental yes target positive allosteric modulator Details Loprazolam experimental yes target positive allosteric modulator Details Oxazepam acetate experimental yes target positive allosteric modulator Details 1,2-Benzodiazepine approved, investigational unknown target positive allosteric modulator Details Cinazepam experimental yes target positive allosteric modulator Details Bentazepam experimental yes target positive allosteric modulator Details Mexazolam experimental yes target positive allosteric modulator Details Remimazolam approved, investigational yes target positive allosteric modulator Details Ganaxolone approved, investigational yes target positive allosteric modulator Details Zuranolone approved, experimental yes target positive allosteric modulator Details