Skin Irritation (DBCOND0062614)

Identifiers

Synonyms

Irritation in Skin / Skin irritants / Skin irritation / Skin irritation (finding) / Irritation skin

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aluminum hydroxide	An antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Ammonia	Indicated for use as a smelling salt to treat or prevent fainting. (when radiolabelled) Indicated for diagnostic PET imaging of the myocardium under rest or pharmacologic stress conditions to evaluate...	Glutaminase liver isoform, mitochondrialenzyme Glutamine synthetaseenzyme Carbamoyl-phosphate synthase [ammonia], mitochondrialenzyme
Benzocaine	A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.	Sodium channel protein type 10 subunit alphatarget ATP-dependent translocase ABCB1transporter Liver carboxylesterase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Albumincarrier alpha1-acid glycoproteincarrier
Benzyl alcohol	An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older.	Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Aldehyde dehydrogenase, mitochondrialenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme
Camphor	A compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.	Camphor 5-monooxygenasetarget Transient receptor potential cation channel subfamily V member 1target Transient receptor potential cation channel subfamily V member 3target Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target
Centella asiatica	Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.	No drug targets
Cetrimonium	A compound that can be used as a topical antiseptic.	Cyclopropane mycolic acid synthase MmaA2target Cyclopropane mycolic acid synthase 1target
Cinchocaine	An anesthetic used for local or regional anesthesia.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Cholinesteraseenzyme Calmodulintarget
Dimethicone 410	Dimethicone is approved as a transdermal drug delivery system. Dimethicone 410 is part of the simethicone element in Dow Corning Q7-2242 LVA which is an antifoam.[L2163, L2166] Some OTC's containing...	No drug targets
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Ethanol	For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...	Gamma-aminobutyric acid receptor subunit alpha-1target Glutamate receptor ionotropic, NMDA 3Atarget Glycine receptor subunit alpha-1target Glycine receptor subunit alpha-2target Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 4A11enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme Alcohol dehydrogenase 1Cenzyme Alcohol dehydrogenase class-3enzyme Voltage-dependent L-type calcium channel subunit beta-1target 5-hydroxytryptamine receptor 3Atarget All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Gamma-aminobutyric acid receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-10target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Gamma-aminobutyric acid receptor subunit alpha-5target Gamma-aminobutyric acid receptor subunit alpha-4target All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme Gamma-aminobutyric acid receptor subunit alpha-3target Glutamate receptor 1target Voltage-dependent calcium channel gamma-1 subunittarget Neuronal acetylcholine receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-6target Glutamate receptor 2target Glutamate receptor 4target Glutamate receptor 3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target G protein-activated inward rectifier potassium channel 1target G protein-activated inward rectifier potassium channel 2target Vascular cell adhesion protein 1target Equilibrative nucleoside transporter 1target G protein-activated inward rectifier potassium channel 4target Neuronal acetylcholine receptor subunit alpha-7target Neuronal acetylcholine receptor subunit alpha-9target Gamma-aminobutyric acid receptor subunit beta-1target Gamma-aminobutyric acid receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit beta-2target Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Alcohol dehydrogenase 6enzyme Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-5target Neuronal acetylcholine receptor subunit alpha-6target Neuronal acetylcholine receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit gamma-1target Gamma-aminobutyric acid receptor subunit gamma-3target Gamma-aminobutyric acid receptor subunit epsilontarget Gamma-aminobutyric acid receptor subunit pitarget Gamma-aminobutyric acid receptor subunit thetatarget Gamma-aminobutyric acid receptor subunit deltatarget Aldo-keto reductase family 1 member A1enzyme Equilibrative nucleoside transporter 2target 5-hydroxytryptamine receptor 3Etarget 5-hydroxytryptamine receptor 3Btarget 5-hydroxytryptamine receptor 3Dtarget 5-hydroxytryptamine receptor 3Ctarget Voltage-dependent calcium channel gamma-2 subunittarget G protein-activated inward rectifier potassium channel 3target Neural cell adhesion molecule L1target Acetylcholinesterasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target
Fluconazole	A triazole antifungal used to treat various fungal infections including candidiasis.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Cytochrome P450 3A5enzyme
Hyaluronic acid	A glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.	CD44 antigentarget Intercellular adhesion molecule 1target Hyaluronan mediated motility receptortarget Neurocan core proteintarget Versican core proteintarget Complement component 1 Q subcomponent-binding protein, mitochondrialtarget Hyaluronan and proteoglycan link protein 1target Hyaluronan and proteoglycan link protein 3target Hyaluronan-binding protein 2target Layilintarget Stabilin-2target Tumor necrosis factor-inducible gene 6 proteintarget Interphotoreceptor matrix proteoglycan 2target Intracellular hyaluronan-binding protein 4target Hyaluronidase enzymesenzyme ATP-binding cassette sub-family C member 5transporter Lymphatic vessel endothelial hyaluronic acid receptor 1target
Hydrocortisone acetate	A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter
Ichthammol	Ichthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed...	No drug targets
Lidocaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Epidermal growth factor receptortarget Sodium channel protein type 9 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Sodium channel protein type 4 subunit alphatarget Alpha-1-acid glycoprotein 1target Alpha-1-acid glycoprotein 2target Sodium channel protein type 11 subunit alphatarget
Neomycin	An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget Extracellular calcium-sensing receptortarget
Palmitic Acid	A fatty used as a food additive and emollient or surfactant in cosmetics.	Rhodopsintarget Albumincarrier Palmitoyl-protein thioesterase 1target Myelin P2 proteintarget Fatty acid-binding protein, adipocytecarrier Fatty acid-binding protein 5carrier Glycodelintarget Fatty acid-binding protein, heartcarrier Hepatocyte nuclear factor 4-gammatarget Lipid binding proteintarget Cytochrome P450 2C8target Trafficking protein particle complex subunit 3target Fatty acid-binding protein TM_1468target Fatty acid-binding protein, intestinalcarrier Alpha-lactalbumintarget Peroxisome proliferator-activated receptor alphatarget Fatty acid-binding protein, adipocytetarget Fatty acid-binding protein 5target
Petrolatum	For use as an over the counter skin protectant [FDA Label]. Commonly used to treat diaper rash and chapped lips [FDA Label] .	No drug targets
Pramocaine	A local anesthetic and antipruritic agent found in various topical preparations.	Voltage-gated sodium channel alpha subunittarget
Sodium bicarbonate	A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.	Electrogenic sodium bicarbonate cotransporter 1transporter Sodium bicarbonate cotransporter 3transporter Electroneutral sodium bicarbonate exchanger 1transporter Electrogenic sodium bicarbonate cotransporter 4transporter Hydrogen ionstarget Sodium-driven chloride bicarbonate exchangertransporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget A-type voltage-gated potassium channel KCND3target
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Talc	A mineral used to prevent recurrence of malignant pleural effusions in symptomatic patients during thoracoscopy or open thoracotomy.	No drug targets
Zinc	An essential element commonly used for the treatment of patients with documented zinc deficiency.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Programmed cell death protein 6target DAN domain family member 5target Metallothionein-1Atarget Alpha-1B-glycoproteintarget Alpha-2-macroglobulintarget Angiotensinogentarget Alpha-2-HS-glycoproteintarget Serum amyloid P-componenttarget Apolipoprotein A-Itarget Apolipoprotein A-IItarget Apolipoprotein A-IVtarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement component C8 alpha chaintarget Complement component C8 beta chaintarget Complement component C8 gamma chaintarget Complement factor Btarget Complement factor Htarget Complement factor Itarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Desmoplakintarget Coagulation factor XIItarget Coagulation factor XIII B chaintarget Prothrombintarget Ficolin-3target Fibrinogen alpha chaintarget Fibronectintarget Gelsolintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobin-related proteintarget Hornerintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Immunoglobulin heavy constant alpha 1target Immunoglobulin heavy constant mutarget Immunoglobulin kappa variable 1-17target Immunoglobulin kappa variable 3-20target Immunoglobulin lambda variable 3-21target Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Junction plakoglobintarget Plasma kallikreintarget Kininogen-1target Keratin, type II cytoskeletal 1target Keratin, type I cytoskeletal 10target Keratin, type I cytoskeletal 14target Keratin, type I cytoskeletal 16target Keratin, type II cytoskeletal 2 epidermaltarget Keratin, type II cytoskeletal 5target Keratin, type II cytoskeletal 6Atarget Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Kallistatintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carbonic anhydrase 1enzyme
Zinc acetate	A medication used to treat zinc deficiency.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Programmed cell death protein 6target DAN domain family member 5target Metallothionein-1Atarget Alpha-1B-glycoproteintarget Alpha-2-macroglobulintarget Angiotensinogentarget Alpha-2-HS-glycoproteintarget Serum amyloid P-componenttarget Apolipoprotein A-Itarget Apolipoprotein A-IItarget Apolipoprotein A-IVtarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement component C8 alpha chaintarget Complement component C8 beta chaintarget Complement component C8 gamma chaintarget Complement factor Btarget Complement factor Htarget Complement factor Itarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Desmoplakintarget Coagulation factor XIItarget Coagulation factor XIII B chaintarget Prothrombintarget Ficolin-3target Fibrinogen alpha chaintarget Fibronectintarget Gelsolintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobin-related proteintarget Hornerintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Immunoglobulin heavy constant alpha 1target Immunoglobulin heavy constant mutarget Immunoglobulin kappa variable 1-17target Immunoglobulin kappa variable 3-20target Immunoglobulin lambda variable 3-21target Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Junction plakoglobintarget Plasma kallikreintarget Kininogen-1target Keratin, type II cytoskeletal 1target Keratin, type I cytoskeletal 10target Keratin, type I cytoskeletal 14target Keratin, type I cytoskeletal 16target Keratin, type II cytoskeletal 2 epidermaltarget Keratin, type II cytoskeletal 5target Keratin, type II cytoskeletal 6Atarget Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Kallistatintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carbonic anhydrase 1enzyme Carboxypeptidase Eenzyme Alcohol dehydrogenase 1Cenzyme Insulin-degrading enzymeenzyme Superoxide dismutase [Cu-Zn]enzyme
Zinc oxide	A mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01922700	Effects of Pepper Gas Exposure in Non-combatant Bystanders.	No drug interventions	Not Available	Not Available	completed
NCT01888887	Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Daily Facial Cleanser	No drug interventions	supportive_care	Not Available	completed
NCT01892657	Cetaphil® Daily Facial Moisturizer With Sunscreen SPF 50+ - Human Repeat Insult Patch Test	Avobenzone Homosalate Octisalate Octocrylene Oxybenzone Triclosan	supportive_care	4	completed
NCT01821274	A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design	Diltiazem Sodium lauryl sulfate	treatment	1	unknown_status
NCT01806831	Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment	No drug interventions	treatment	Not Available	completed
NCT01887860	Patch Test Skin Irritation/Sensitization of Cetaphil Daily Facial Moisturizer SPF 50	No drug interventions	supportive_care	Not Available	completed
NCT02645110	Evaluation of Effectiveness and Mildness of Whole-natural Hand-wash Formulations	No drug interventions	prevention	Not Available	unknown_status
NCT01892423	Repeat Insult Patch Test for Daily Advance Cetaphil Moisturizing Lotion	No drug interventions	supportive_care	Not Available	completed
NCT02400320	Local Skin Safety Study of a Topical Pain Relief Spray Containing a Combination of Diclofenac, Methyl Salicylate, and Menthol	No drug interventions	other	4	withdrawn
NCT03397862	A Skin Irritation Assessment of Once-Weekly Corplex™ Donepezil Transdermal Delivery System	Donepezil	other	1	completed
NCT02968446	Effect of Vitamin D After Application With Valchlor	Mechlorethamine	supportive_care	0	completed
NCT01892410	Patch Test Skin Irritation/Sensitization of Cetaphil Restoraderm Skin Restoring Body Wash	No drug interventions	supportive_care	Not Available	completed
NCT01887808	Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Dermacontrol Oil Control Moisturizer SPF 30	No drug interventions	supportive_care	Not Available	completed