| Tryptophan | An amino acid commonly found as a component of total parenteral nutrition. |
| Fluvoxamine | A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. |
| Amphetamine | A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). |
| Caffeine | A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. |
| Citalopram | A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. |
| Reboxetine | For the treatment of clinical depression. |
| Venlafaxine | A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. |
| Protriptyline | A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. |
| Mirtazapine | A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. |
| Tacrine | For the palliative treatment of mild to moderate dementia of the Alzheimer's type. |
| Methylphenidate | A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). |
| Imipramine | A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. |
| Fluoxetine | A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. |
| Duloxetine | A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. |
| Nortriptyline | A tricyclic antidepressant used in the treatment of depression. |
| Amoxapine | A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. |
| Trazodone | A serotonin uptake inhibitor used to treat major depressive disorder. |
| Galantamine | A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. |
| Paroxetine | A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. |
| Trimipramine | A tricyclic antidepressant used to treat depression. |
| Modafinil | A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. |
| Tranylcypromine | A monoamine oxidase inhibitor used to treat major depressive disorder. |
| Phenelzine | A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. |
| Minaprine | For the treatment of depression |
| Donepezil | An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. |
| Maprotiline | A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. |
| Rivastigmine | A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. |
| Memantine | An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. |
| Doxepin | A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. |
| Nefazodone | An antidepressant used in the treatment of depression. |
| Desipramine | A tricyclic antidepressant used in the treatment of depression. |
| Bupropion | A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. |
| Moclobemide | A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. |
| Escitalopram | A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). |
| Pemoline | A central nervous system (CNS) stimulant that was previously used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. |
| Clomipramine | A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. |
| Isocarboxazid | A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. |
| Lisdexamfetamine | A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. |
| St. John's Wort | An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. |
| Ginkgo biloba | Appears to be effective in: alleviating age-related memory impairment in some elderly people with mild to moderate age-related memory or cognitive impairment; improving cognitive function in healthy young to middle-aged... |
| Fencamfamin | For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. |
| Dextroamphetamine | A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. |
| Metamfetamine | A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. |
| Oxitriptan | For use as an antidepressant, appetite suppressant, and sleep aid. |
| Aniracetam | Compound with anti-depressive properties used as a mental performance enhancer. |
| Nialamide | Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. |
| Nomifensine | Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... |
| Zimelidine | For the treatment of depression. |
| Amineptine | For the treatment of depression. |
| Milnacipran | A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. |
| Mianserin | For the treatment of depression. |
| Armodafinil | A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. |
| Propentofylline | Investigated for use/treatment in alzheimer's disease. |
| Agomelatine | Agomelatine is indicated to treat major depressive episodes in adults. |
| Vilazodone | An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. |
| Desvenlafaxine | An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. |
| Dexmethylphenidate | A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. |
| Acetylcarnitine | Acetylcarnitine is not approved for any indication in the United states and Canada, but it is approved and indicated in Italy for cerebrovascular disorders, mental function disorders, peripheral nerve disorders,... |
| Adrafinil | Used to relieve excessive sleepiness and inattention in elderly patients. |
| Dimetacrine | Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... |
| Butriptyline | Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. |
| Vortioxetine | An atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). |
| Idebenone | An analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON). |
| Dosulepin | Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. |
| Viloxazine | Indicated for the treatment of clinical depression. |
| Etoperidone | Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... |
| Piracetam | Indicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies . |
| Toloxatone | For the treatment of major depressive disorder. |
| Iproclozide | For the treatment of depression. |
| Tianeptine | Used primarily in the treatment of major depressive disorder and anxiety . It is currently being studied for fibromyalgia pain treatment . |
| Pipradrol | A central nervous stimulant ingredient in a product used to treat functional fatigue. |
| Vinpocetine | Vinpocetine has been investigated for the treatment of Epilepsy. |
| Gepirone | Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. |
| Opipramol | Opipramol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders. |
| Pivagabine | Pivagabine has been used in trials studying the treatment of Stress and Anxiety. |
| Pyritinol | Pyritinol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders. |
| Medifoxamine | Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases... |
| Dibenzepin | Dibenzepin is approved for use in Europe. |
| Alaproclate | Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... |
| Quinupramine | Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . |
| Pramiracetam | Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug... |
| Fenozolone | Not Annotated |
| Deanol | Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... |
| Melitracen | Not Annotated |
| Lofepramine | Not Annotated |
| Pirisudanol | Not Annotated |
| Prolintane | Not Annotated |
| Phenibut | Not Annotated |
| Oxaflozane | Not Annotated |
| Iprindole | Not Annotated |
| Mebicar | Not Annotated |
| Nizofenone | Not Annotated |
| Bifemelane | Not Annotated |
| Oxiracetam | Not Annotated |
| Ipidacrine | Not Annotated |
| Meclofenoxate | Not Annotated |
| Imipramine oxide | Not Annotated |
| Fipexide | Not Annotated |
| Linopirdine | Not Annotated |
| Fenethylline | Not Available |
| Citicoline | Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar... |
| Iproniazid | For the treatment of depression (originally intended to treat tuberculosis). |
| Sertraline | A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. |
| Esketamine | A NMDA receptor antagonist used for treatment-resistant depression. |
| Solriamfetol | Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. |