Dental Local Anesthesia (DBCOND0134266)

Identifiers

Synonyms

Anesthesia, Dental / Dental Anesthesia / Dental local anesthesia / Dental local anaesthesia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Articaine	A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures.	No drug targets
Cetrimonium	A compound that can be used as a topical antiseptic.	Cyclopropane mycolic acid synthase MmaA2target Cyclopropane mycolic acid synthase 1target
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.	Alpha-1A adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Tumor necrosis factortarget Catechol O-methyltransferaseenzyme Monoamine oxidaseenzyme
Vasopressin	A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.	Vasopressin V1a receptortarget Vasopressin V2 receptortarget Vasopressin V1b receptortarget ATP-binding cassette sub-family C member 2transporter Oxytocin receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00309361	Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Mandibular Procedures	Phentolamine	treatment	3	completed
NCT05839093	Anesthesia Techniques in Symptomatic Mandibular Molars With Irreversible Pulpitis	No drug interventions	treatment	Not Available	completed
NCT00363207	Behavior of Children Related to Numbness After Dental Local Anesthesia	No drug interventions	Not Available	Not Available	completed
NCT00309335	Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Maxillary Procedures	Phentolamine	treatment	3	completed
NCT05423392	Efficacy of 4% Articaine Terminal Anesthesia in the Lateral Jaw Region in Children	No drug interventions	treatment	Not Available	completed
NCT03318952	Articaine vs Lidocaine for Pediatric Dental Procedures	Articaine Lidocaine	treatment	4	withdrawn
NCT00309322	Study of NV-101 for Safety and Efficacy in Pediatric Dental Patients Undergoing Procedures	Phentolamine	treatment	2	completed
NCT04317508	Using Anesthetic Gel Patches to Reduce Pain of Palatal Injection	Benzocaine	treatment	1 / 2	completed
NCT02062996	Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption	Oxymetazoline	treatment	2	withdrawn
NCT03443726	Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?	Articaine Epinephrine	treatment	Not Available	completed
NCT06519838	Effect of Pre-Warming of Local Anesthesia in Reducing Pain Perception During Injection in Children	No drug interventions	treatment	Not Available	completed
NCT03502135	Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment	Oxymetazoline Tetracaine	treatment	4	withdrawn
NCT01474382	Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients	Phentolamine	treatment	4	completed