This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Iofetamine I-123
- DrugBank Accession Number
- DB09480
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Iofetamine I-123 (DB09480)
- Weight
- Average: 299.189
Monoisotopic: 299.049522528 - Chemical Formula
- C12H18IN
- Synonyms
- Iodine iofetamine (123I)
- Iofetamine (123 I)
- Iofetamine (123I)
- Iofetamine I 123
- Iofetamine, I-123
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Iofetamine I-123. Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Iofetamine I-123. Acemetacin The risk or severity of hypertension can be increased when Iofetamine I-123 is combined with Acemetacin. Acetazolamide Acetazolamide may decrease the excretion rate of Iofetamine I-123 which could result in a higher serum level. Acetophenazine Acetophenazine may decrease the stimulatory activities of Iofetamine I-123. - Food Interactions
- Not Available
Products
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Ingredient UNII CAS InChI Key Iofetamine hydrochloride I-123 R5O1XB5L3M 85068-76-4 AFLDFEASYWNJGX-FOHXBPHZSA-N
Categories
- ATC Codes
- V09AB01 — Iodine iofetamine (123i)
- Drug Categories
- Agents producing tachycardia
- Agents that produce hypertension
- Amines
- Amphetamines
- Central Nervous System
- Compounds used in a research, industrial, or household setting
- Diagnostic Radiopharmaceuticals
- Diagnostic Uses of Chemicals
- Ethylamines
- Indicators and Reagents
- Iodine (123I) Compounds
- Laboratory Chemicals
- Phenethylamines
- Radiopharmaceuticals
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Sympathomimetics
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Phenethylamines
- Direct Parent
- Amphetamines and derivatives
- Alternative Parents
- Phenylpropanes / Iodobenzenes / Aralkylamines / Aryl iodides / Dialkylamines / Organopnictogen compounds / Organoiodides / Hydrocarbon derivatives
- Substituents
- Amine / Amphetamine or derivatives / Aralkylamine / Aromatic homomonocyclic compound / Aryl halide / Aryl iodide / Halobenzene / Hydrocarbon derivative / Iodobenzene / Organic nitrogen compound
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- LV23B78IJC
- CAS number
- 75917-92-9
- InChI Key
- ISEHJSHTIVKELA-DCWJVSPSSA-N
- InChI
- InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3/i13-4
- IUPAC Name
- {1-[4-(¹²³I)iodophenyl]propan-2-yl}(propan-2-yl)amine
- SMILES
- CC(C)NC(C)CC1=CC=C([123I])C=C1
References
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00511 mg/mL ALOGPS logP 3.58 ALOGPS logP 3.94 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 10.35 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 71.01 m3·mol-1 Chemaxon Polarizability 27.78 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-000f-9170000000-55a55501ee63688c2f15 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udu-8098000000-989e6595c4f96f4e0c1d Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0f6x-0296000000-b795d8787ce3b0da4a07 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-00kf-9040000000-965bcb6a36fc91c5e9bb Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0900000000-8a3cc8698f94470fe22b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-014l-9370000000-ed541c48eed44eb32e3e Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0900000000-87e16e8a453ce510d903 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 155.39853 predictedDeepCCS 1.0 (2019) [M+H]+ 157.75653 predictedDeepCCS 1.0 (2019) [M+Na]+ 163.84967 predictedDeepCCS 1.0 (2019)
Drug created at November 30, 2015 19:10 / Updated at June 12, 2020 16:52