Sympathomimetics

Name
Sympathomimetics
Accession Number
DBCAT000438
Description

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Drugs
DrugDrug Description
2,5-Dimethoxy-4-ethylamphetamineNot Available
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties.
AcebutololA selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults.
AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
BrolamfetamineNot Available
BucindololBucindolol has been investigated in Heart Failure.
CeliprololA beta-blocker for the management of hypertension and angina pectoris.
ChlorphentermineUsed as an appetite suppressant.
ClenbuterolA decongestant and bronchodilator used in a variety of respiratory conditions.
CloforexCloforex is a small molecule drug. Cloforex has a monoisotopic molecular weight of 255.1 Da.
DextroamphetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
DopamineA catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension.
EpanololEpanolol is an beta blocker.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
EtilefrineAn adrenergic agonist primarily of α1 and β1 receptors used as an anti-hypotensive.
FamprofazoneFamprofazone is a nonsteroidal anti-inflammatory agent found in combination products such as ‘Gewodin’ which is marketed in Taiwan. It is important to note that the drug is metabolized to methamphetamine...
FenoterolA beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma.
FenozoloneNot Annotated
GepefrineNot Annotated
Hexamethylene diamineNot Available
HydroxyamphetamineAn indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes.
Iofetamine I-123Not Annotated
IsoprenalineA catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block.
IsoxsuprineA beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease.
LabetalolAn alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.
LevonordefrinA topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures.
LisdexamfetamineA central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders.
MefenorexNot Annotated
MephedroneMephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders.
MephentermineA sympathomimetic agent used in the treatment of hypotension.
MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
MetaraminolFor the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
MethoxamineAn alpha adrenergic agonist used to treat hypotension.
MethoxyphenamineNot Annotated
MethylenedioxyethamphetamineNot Available
MethyloneMethylone is under investigation in clinical trial NCT05741710 (A Study to Assess the use of Methylone in the Treatment of PTSD).
MidodrineAn alpha-adrenergic agonist used to treat orthostatic hypotension.
MidomafetamineClinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used...
MMDAMMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present.
NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
NorepinephrineA sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
NylidrinA vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders.
OrciprenalineA beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD.
OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
PhendimetrazineA sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity.
PhenmetrazineUsed as an anorectic in the treatment of obesity.
PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
PrenalterolNot Annotated
ProcaterolA beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
RacepinephrineA bronchodilator used to treat intermittent asthma.
RitobegronRitobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin...
RitodrineAn adrenergic beta agonist used to treat premature labor.
SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
TenamfetamineAn amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons...
TerbutalineA beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor.
TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
TramazolineA sympathomimetic indicated for nasal decongestion.
TretoquinolNot Annotated
TyramineTyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An...