This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Cefodizime is a broad-spectrum, third-generation cephalosporin used to treat serious infections caused by susceptible bacteria.
- Generic Name
- Cefodizime
- DrugBank Accession Number
- DB13470
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Cefodizime (DB13470)
- Weight
- Average: 584.669
Monoisotopic: 584.027629784 - Chemical Formula
- C20H20N6O7S4
- Synonyms
- CDZM
- Cefodizima
- Cefodizime
- Cefodizimum
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Cefodizime may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefodizime. Aceclofenac The risk or severity of nephrotoxicity can be increased when Aceclofenac is combined with Cefodizime. Acemetacin The risk or severity of nephrotoxicity can be increased when Cefodizime is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Cefodizime is combined with Acenocoumarol. Acetaminophen Cefodizime may decrease the excretion rate of Acetaminophen which could result in a higher serum level. Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefodizime. Aclidinium Cefodizime may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Cefodizime may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Cefodizime. 
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- Not Available
Products
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Ingredient UNII CAS InChI Key Cefodizime sodium HC1T51593A 86329-79-5 WBOBLQIRACJNPA-AEKYOGSZSA-L
Categories
- ATC Codes
- J01DD09 — Cefodizime
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Lactams
- Sub Class
- Beta lactams
- Direct Parent
- Cephalosporins
- Alternative Parents
- N-acyl-alpha amino acids and derivatives / 2,4,5-trisubstituted thiazoles / 2,4-disubstituted thiazoles / Alkylarylthioethers / 1,3-thiazines / 2-amino-1,3-thiazoles / Dicarboxylic acids and derivatives / Tertiary carboxylic acid amides / Heteroaromatic compounds / Secondary carboxylic acid amides show 12 more
- Substituents
- 1,3-thiazol-2-amine / 2,4,5-trisubstituted 1,3-thiazole / 2,4-disubstituted 1,3-thiazole / Alkylarylthioether / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Aromatic heteropolycyclic compound / Aryl thioether show 28 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- cephalosporin, 1,3-thiazole, oxime O-ether (CHEBI:63214)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Z31298J4HQ
- CAS number
- 69739-16-8
- InChI Key
- XDZKBRJLTGRPSS-BGZQYGJUSA-N
- InChI
- InChI=1S/C20H20N6O7S4/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32)/b25-12-/t13-,17-/m1/s1
- IUPAC Name
- (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- SMILES
- [H][C@]12SCC(CSC3=NC(C)=C(CC(O)=O)S3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O
References
- General References
- AIFA Product Information: Modivid (cefodizime) powder for solution for injection [Link]
- External Links
- Human Metabolome Database
- HMDB0041850
- KEGG Drug
- D07643
- ChemSpider
- 4514859
- BindingDB
- 50422690
- 20485
- ChEBI
- 63214
- ChEMBL
- CHEMBL2303613
- ZINC
- ZINC000003830421
- Wikipedia
- Cefodizime
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, for solution Intramuscular; Parenteral 1 G/4ML Injection, powder, for solution Intravenous; Parenteral 2 G/10ML Injection, powder, for solution Parenteral 1 G/4ML Injection, powder, for solution Parenteral 250 MG/2ML Injection, powder, for solution Parenteral 500 MG/2ML - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.068 mg/mL ALOGPS logP 1.07 ALOGPS logP 0.24 ChemAxon logS -3.9 ALOGPS pKa (Strongest Acidic) 2.68 ChemAxon pKa (Strongest Basic) 3.45 ChemAxon Physiological Charge -2 ChemAxon Hydrogen Acceptor Count 11 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 197.4 Å2 ChemAxon Rotatable Bond Count 10 ChemAxon Refractivity 136.93 m3·mol-1 ChemAxon Polarizability 56.47 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 0 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:42 / Updated at May 05, 2021 20:31